An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over
The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence of non-infectious illnesses and their risk factors and described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic in south east England. Patients age ≥50 years were invited to complete… Continue reading An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over
Screening for asymptomatic lymphogranuloma venereum co-infection in men who have sex with men newly diagnosed with HIV, hepatitis C or syphilis
Patients diagnosed with lymphogranuloma venereum have high rates of co-infection with HIV, syphilis and hepatitis C. The aim of this enhanced surveillance was to screen all men who have sex with men (MSM) newly diagnosed with HIV, syphilis or hepatitis C for co-infection with asymptomatic lymphogranuloma venereum as part of the recommended sexual health screen.… Continue reading Screening for asymptomatic lymphogranuloma venereum co-infection in men who have sex with men newly diagnosed with HIV, hepatitis C or syphilis
A case of primary adrenal diffuse large B-cell lymphoma in HIV
Primary adrenal diffuse large B-cell lymphoma in HIV is a very rare, highly aggressive extra-nodal lymphoma. There is only one previous case reported in the literature. Our patient presented with isolated bilateral adrenal masses with no lymphadenopathy or visceral involvement, which made the diagnosis challenging. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZwvB9P via IFTTT
HIV control in postpartum mothers: a turbulent time
We conducted an audit looking at the management of HIV-positive women in the postpartum period. We found that of the women with a previous AIDS-defining condition or a CD4 count <350 cells/µL, 83% were correctly continued on antiretroviral therapy (ART) and 84.1% of these had good virological control. ART was correctly stopped in 100% of… Continue reading HIV control in postpartum mothers: a turbulent time
Impact of switching from lopinavir/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: the ATAzanavir & GLUcose metabolism (ATAGLU) study
Previous studies have reported that protease inhibitors (PIs) can contribute to glycaemic alterations. However, there are few trials examining the direct effect of a single PI. The objective of the study was to evaluate the modifications of glucose and lipid profiles after a switch from lopinavir/ritonavir (LPV/r) to atazanavir, used as ritonavir-boosted (ATV/r) or un-boosted.… Continue reading Impact of switching from lopinavir/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: the ATAzanavir & GLUcose metabolism (ATAGLU) study
Syphilis detection: evaluation of serological screening and pilot reverse confirmatory assay algorithm in blood donors
Serological assays are still considered the most useful tests in the diagnosis of syphilis. Since no single serological assay is able to provide a satisfactory result, in our laboratory we have evaluated the usefulness of a commercially-available immunoblot to diagnose syphilis infection among blood donors. From October 2012 to June 2013, 4572 blood donors were… Continue reading Syphilis detection: evaluation of serological screening and pilot reverse confirmatory assay algorithm in blood donors
Testing for latent tuberculosis infection using interferon gamma release assays in commercial sex workers at an outreach clinic in Birmingham
This report demonstrates that using interferon gamma release assays to screen for latent tuberculosis infection in female commercial sex workers in an outreach sexual health clinic is feasible and acceptable. Routine interferon gamma release assay use successfully identified high numbers of latent tuberculosis infection. Innovative approaches to treatment and follow up were required to improve… Continue reading Testing for latent tuberculosis infection using interferon gamma release assays in commercial sex workers at an outreach clinic in Birmingham
‘The waiting game: are current chlamydia and gonorrhoea near-patient/point-of-care tests acceptable to service users and will they impact on treatment?
The objective of this study was to assess the length of time service users were prepared to wait for chlamydia and gonorrhoea (CT/GC) near-patient/point-of-care test (NP-POCT) results and to determine the possible effect on management. Individuals attending two UK clinics from November 2013 to February 2014 were surveyed asking the maximum length of time they… Continue reading ‘The waiting game: are current chlamydia and gonorrhoea near-patient/point-of-care tests acceptable to service users and will they impact on treatment?
Total laparoscopic intestinal vaginoplasty as neovaginal reconstruction in an HIV-positive transgender woman
A 46-year-old, HIV-positive transgender woman of South American ethnicity consulted our outpatient clinic to discuss the possibilities of a surgical, secondary neovaginal reconstruction because of complete stenosis of her inverted penile skin-lined neovagina. She was taking abacavir/lamivudine and nevirapine as antiretroviral therapy. We successfully performed a total laparoscopic sigmoid vaginoplasty without any complications. There was… Continue reading Total laparoscopic intestinal vaginoplasty as neovaginal reconstruction in an HIV-positive transgender woman
UNUSUAL CAUSE OF BLEEDING PER RECTUM IN CHILDREN – CASE REPORT
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
2016-06-07T23-38-39Z *Source:* International Journal of Current Research and Review Ahmed A. Al-Jarie, Abdullah Hilal, Mohammed R. AL-HAYLI, Zainah A. Sabr, Safa M. AL-Haider, Maha T. almofareh, Nihal I. Mirza. Background: Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum. The Zygomycetes includes two fungal orders: Mucorales and Entomophthorales, with completely different pathogenic potentials. Basidiobolusranarum was first described in 1886 in frogs. We present a case of bleeding per rectum in a 3-year-old male patient, resident of Southwestern of Saudi ... περισσότερα »
Use of the bougie for intubation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
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BIOINFORMATICS ADVANCES IN GENOMICS – A REVIEW
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
2016-06-07T23-38-39Z *Source:* International Journal of Current Research and Review Raphael John Ogbe, Dickson O. Ochalefu, Olumide B. Olaniru. Genomics is a discipline in genetics that applies recombinant DNA technology, DNA sequencing methods and bioinformatics to sequence, assemble and analyze the function and structure of genome, the complete set of DNA within a single cell of an organism. Bioinformatics is an inter-disciplinary scientific field that develops methods for storing, retrieving, organizing and analyzing biological data. The advances in bioinformatics have in turn ma... περισσότερα »
Visual tour of EMT training
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
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QUANTIFICATION OF ANTIOXIDANTS IN UNDERUTILIZED VEGETABLE LEAVES
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
2016-06-07T23-38-39Z *Source:* International Journal of Current Research and Review Mary Jenefer Sharmila P., Dorothy Jaganathan, Kumaravel S.. Introduction: Green leafy vegetables are an excellent source of bioactive compounds beyond human nutrition. There are many underutilized vegetable leaves which are equally a power house of bioactive compounds with reference to antioxidants. Much literature confirms that brassicca vegetables are high in antioxidants but the antioxidant studies these vegetable leaves are scarce as they are underutilized and neglected hence the present study wa... περισσότερα »
Use of the bougie for intubation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
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Development of an effective therapy and objective assessment for children with birth injuries.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 9 δευτερόλεπτα
Sitting in a Huple, a patented hemisphere-like tool, permanently stimulates the vestibular system, thus improving the balancing ability of children with movement disorders. The Gezenguz Foundation for Children with Birth Injuries has been successfully applying this tool in therapy. By attaching x-Inertial Measurement Unit, a wireless three-dimensional orientation sensor, to the Huple, it can serve as an input peripheral for simple PC games. Children are thus motivated; they willingly perform balance training as well as participate in the game-like test. This improves the accuracy an... περισσότερα »
Can bias evaluation provide protection against false negative results in QT studies without a positive control using exposure response analysis?
Abstract The revised ICH E14 document allows the use of exposure-response analysis to exclude a small QT effect of a drug. If plasma levels exceeding clinically relevant are achieved, a positive control is not required. In cases where this cannot be achieved, there may be a need for metrics to protect against false negative results. The objectives of this study were to create bias in ECG laboratory QT interval measurements and define a metric that can be used to detect bias severe enough to cause false negative results using exposure-response analysis. Data from the IQ-CSRC study,... περισσότερα »
Prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats
Abstract Background We recently reported the involvement of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunit upregulation and phosphorylation in the rostral cingulate cortex (rCC) as the underlying mechanism of acute esophageal acid-induced cortical sensitization. Based on these findings, we proposed to investigate whether prolonged esophageal acid exposures in rats exhibit homeostatic synaptic scaling through downregulation of AMPA receptor expression in rCC neurons. We intended to study further whether this compensatory mechanism is impaired when rat... περισσότερα »
Relapsing drug-induced hypersensitivity syndrome.
Purpose of review: Drug-induced hypersensitivity syndrome (DIHS) is a serious adverse drug reaction with potential morbidity and mortality. 'Flare up' or relapses in DIHS is a rare but important feature. These relapses may occur within days to several weeks, even after discontinuation of the offending drug. In this article, we review the pathogenesis of DIHS, implication of human herpesvirus 6 reactivation, and describe published case reports of patients with relapsing DIHS. Recent findings: Common drugs associated with DIHS include (but are not limited to) antiepileptics such as ca... περισσότερα »
Comparison of Antigenic Dominants of VP7 in G9 and G1 Rotavirus Strains Circulating in La Rioja, Argentina, with the Vaccine Strains
Viral Immunology , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1X9Il87 via IFTTT
Prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 19 δευτερόλεπτα
Abstract Background We recently reported the involvement of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunit upregulation and phosphorylation in the rostral cingulate cortex (rCC) as the underlying mechanism of acute esophageal acid-induced cortical sensitization. Based on these findings, we proposed to investigate whether prolonged esophageal acid exposures in rats exhibit homeostatic synaptic scaling through downregulation of AMPA […]
Septal surgery
Sutura transeptal — uma alternativa custo-benefício para tamponamento nasal em cirurgia do septo [Livre artigo]: Daniel Pérez Plasencia, Juan Carlos Falcón, Silvia Borkoski Barreiro, María Sacramento Bocanegra-Pérez, Mario Vicente Barrero, Ángel Ramos Macías Braz J Otorhinolaryngol. 2015;82:310-3 Transeptal suturing — a cost-efficient alternative for nasal packing in septal surgery Daniel Pérez Plasenciaa, Juan Carlos Falcóna, Silvia Borkoski Barreiroa, María Sacramento Bocanegra-Pérezb, Mario Vicente Barrerob, Ángel Ramos Macíasa a Departamento de Cirurgia de Cabeça e Pescoço, ... περισσότερα »
Temporal processing in postlingual adult users of cochlear implant
Processamento temporal em adultos pós-linguais usuários de implante coclear [Livre artigo]: Maycon Duarte, Amanda Dal Piva Gresele, Maria Madalena Canina Pinheiro Braz J Otorhinolaryngol. 2015;82:304-9 Maycon Duartea, Amanda Dal Piva Greseleb, Maria Madalena Canina Pinheiroa a Coordenadoria Especial de Fonoaudiologia, Curso de Graduação em Fonoaudiologia, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brasil b Coordenadoria Especial de Fonoaudiologia, Curso de Graduação em Fonoaudiologia, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brasi... περισσότερα »
Sound therapy in patients with tinnitus resistant to previous treatments
Eficácia da terapia sonora em pacientes com zumbido resistente a tratamentos anteriores: importância dos ajustes [Livre artigo]: Flavia Alencar de Barros Suzuki, Fabio Akira Suzuki, Fernando Kaoru Yonamine, Ektor Tsuneo Onishi, Norma Oliveira Penido Braz J Otorhinolaryngol. 2015;82:297-303 Effectiveness of sound therapy in patients with tinnitus resistant to previous treatments: importance of adjustments Flavia Alencar de Barros Suzukia, Fabio Akira Suzukib, Fernando Kaoru Yonamineb, Ektor Tsuneo Onishia, Norma Oliveira Penidoa a Ciências da Saúde, Departamento de Otorrinolaringo... περισσότερα »
Tinnitus and hearing loss in the elderly
Efeitos da amplificação sonora na autopercepção do zumbido e da perda auditiva em idosos [Livre artigo]: Tiago de Melo Araujo, Maria Cecília Martinelli I?rio Braz J Otorhinolaryngol. 2015;82:289-96 Effects of sound amplification in self-perception of tinnitus and hearing loss in the elderly Tiago de Melo Araujoa, Maria Cecília Martinelli I?riob a Programa de Pós-graduação em Ciências, Departamento de Fonoaudiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brasil b Departamento de Fonoaudiologia, Escola Paulista de Medicina, Univers... περισσότερα »
Electrochemotherapy as palliative treatment in patients with thyroid papillary carcinoma
Eletroquimioterapia como tratamento paliativo em pacientes com carcinoma papilar da tireoide [Livre artigo]: Juan José Grau, Miguel Caballero, Cristobal Langdon, Manuel Bernal-Sprekelsen, Jose Luis Blanch Braz J Otorhinolaryngol. 2015;82:285-8 Juan José Graua, Miguel Caballerob, Cristobal Langdonc, Manuel Bernal-Sprekelsenc, Jose Luis Blanchd a Departamento de Oncologia Clínica, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Espanha b Setor de Oncologia Cirúrgica/ORL, Departamento de Oncologi... περισσότερα »
Audiologic evaluations of children with mucopolysaccharidosis
Avaliação audiológica em crianças com mucopolissacaridose [Livre artigo]: Çağıl Gökdoğan, Şenay Altinyay, Ozan Gökdoğan, Hakan Tutar, Bülent Gündüz, İlyas Okur, Leyla Tümer, Yusuf Kemal Kemaloğlu Braz J Otorhinolaryngol. 2015;82:281-4 Çağıl Gökdoğana, Şenay Altinyaya, Ozan Gökdoğanb, Hakan Tutarc, Bülent Gündüza, İlyas Okurd, Leyla Tümere, Yusuf Kemal Kemaloğluc a Departamento de Audiologia, Gazi University Hospital, Ancara, Turquia b Departamento de ORL-CCP, Memorial Hospital, Ancara, Turquia c Departamento de ORL-CCP, Gazi University Hospital, Ancara, Turquia d Departamento de N... περισσότερα »
Partial laryngectomy in glottic cancer
Laringectomia parcial no câncer glótico: complicações e resultados oncológicos [Livre artigo]: Agnaldo José Graciano, Marina Sonagli, Ana Gabriela Clemente da Silva, Carlos Augusto Fischer, Carlos Takahiro Chone Braz J Otorhinolaryngol. 2015;82:275-80 Partial laryngectomy in glottic cancer: complications and oncological results Agnaldo José Gracianoa, Marina Sonaglib, Ana Gabriela Clemente da Silvab, Carlos Augusto Fischera, Carlos Takahiro Chonec a Departamento de Cirurgia, Divisão de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Hospital São José, Joinville, SC, Brasil b... περισσότερα »
Antioxidant therapy in the elderly with tinnitus
Efeito da terapia com antioxidantes sobre o zumbido em idosos [Livre artigo] via Brazilian Journal of Otorhinolaryngology José Fernando Polanski, Alexandra Dezani Soares, Oswaldo Laércio de Mendonça Cruz Braz J Otorhinolaryngol. 2015;82:269-74 Resumo - Texto Completo - PDF José Fernando Polanskia, Alexandra Dezani Soaresb, Oswaldo Laércio de Mendonça Cruzc a Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brasil. Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil b Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brasil c Uni... περισσότερα »
Aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD)
O papel da dessensibilização à aspirina em pacientes portadores de doença respiratória exacerbada por aspirina (DREA) [Livre artigo]: Jonas Willian Spies, Fabiana Cardoso Pereira Valera, Daniel Loiola Cordeiro, Ta?s Nociti de Mendonça, Marcelo Gonçalves Junqueira Leite, Edwin Tamashiro, Luiza Karla Arruda, Wilma Terezinha Anselmo-Lima Braz J Otorhinolaryngol. 2015;82:263-8 The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD) Jonas Willian Spiesa, Fabiana Cardoso Pereira Valeraa, Daniel Loiola Cordeiroa, Ta?s Nociti de Mendonçaa, Mar... περισσότερα »
Complications of otitis media
Complicações das otites média — um problema potencialmente letal ainda presente [Livre artigo]: Norma de Oliveira Penido, Sujana Sreedevi Chandrasekhar, Andrei Borin, André Souza de Albuquerque Maranh?o, José Ricardo Gurgel Testa Braz J Otorhinolaryngol. 2015;82:253-63 Complications of otitis media — a potentially lethal problem still present Norma de Oliveira Penidoa, Sujana Sreedevi Chandrasekharb, Andrei Borina, André Souza de Albuquerque Maranh?oa, José Ricardo Gurgel Testaa a Departamento de Otorrinolaringologia e Cirurgia da Cabeça e Pescoço, Universidade Federal de São Pau... περισσότερα »
Innovative therapeutic targets in chronic sinusitis with nasal polyps
Alvos terapêuticos inovadores na sinusite crônica com pólipos nasais [Livre artigo]: Claus Bachert Braz J Otorhinolaryngol. 2015;82:251-2 Alvos terapêuticos inovadores na sinusite crônica com pólipos nasais Claus Bacherta a Upper Airways Research Laboratory and ENT Department, Ghent University Hospital, Ghent, Bélgica. Division of ENT Diseases, CLINTEC, Karolinska Institute, University of Stockholm, Stockholm, Bélgica Nossas opções terapêuticas atuais para pacientes com sinusite crônica e pólipos nasais consistem em glicocorticosteroides (GCS) tópicos, episódios curtos de GCS oral... περισσότερα »
Laryngeal Electromyographic findings in patients with vocal fold motion asymmetry
Laryngeal Electromyographic findings in patients with vocal fold motion asymmetry: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis Vocal fold motion asymmetry (VFMA) is often attributed to vocal fold paresis or an anatomical variant. Although laryngeal electromyography (LEMG) may be used to evaluate patients with vocal fold paresis, electrodiagnostic findings in VFMA have not been well defined. Study Design Review of a case series Methods Twenty-five symptomatic patients with VFMA were examined by LEMG, and the findings were analyzed. Results Although all ... περισσότερα »
Treatment of rhinosinusitis and histopathology of nasal mucosa
A controlled randomized clinical study: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis To study the pathology of upper airway mucosa, as well as valuate and compare changes in pathology after the treatment of chronic rhinosinusitis (CRS) patients with balloon sinuplasty versus uncinectomy. Methods A prospective randomized controlled trial in patients with CRS of the maxillary sinuses without severe pathology of other sinuses. Patients were randomized into two groups: uncinectomy and balloon sinuplasty. The main variables in our study are histopathology o... περισσότερα »
Intranasal volume increases with age: Computed tomography volumetric analysis in adults
Intranasal volume increases with age: Computed tomography volumetric analysis in adults: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis It is theorized that intranasal cavity volumes change throughout the aging process, possibly secondary to hormonal changes and atrophy of the sinonasal mucosa. Our objective is to compare intranasal volumes from different age groups to test the hypothesis that intranasal cavity volume increases with age. Study Design Case series. Methods An analysis of computed tomography (CT) scans performed for reasons other than sinon... περισσότερα »
Transoral laser microsurgery for managing laryngeal stenosis after reconstructive partial laryngectomies
Transoral laser microsurgery for managing laryngeal stenosis after reconstructive partial laryngectomies: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis To retrospectively analyze our experience of transoral laser microsurgery (TLM) for treating postoperative laryngeal obstruction (POLO) after supracricoid and supratracheal laryngectomy (open partial horizontal laryngectomy [OPHL]) types 2 and 3, and to investigate potential relationships between patients' clinical features and their functional outcomes. Study Design A retrospective cohort study. Methods... περισσότερα »
Age-related changes in mastication are not improved by tongue exercise
in a rat model: Objectives/Hypothesis Aging results in progressive changes in deglutitive functions, which may be due in part to alterations in muscle morphology and physiology. Mastication is a critical component of bolus formation and swallowing, but aging effects on masticatory function have not been well studied. Study Design The purpose of this study was to 1) quantify the effects of aging on mastication, and 2) determine the effects of tongue exercise on mastication in young adult and old rats. We hypothesized that there would be significant differences in mastication charact... περισσότερα »
5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition
5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition: Thyroid , Vol. 0, No. 0. Author information Juliana M. Cazarin, Raquel G. Coelho, Fabio Hecht, Bruno M. Andrade, and Denise P. Carvalho Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Address correspondence to: *Denise Pires de Carvalho, MD, PhD* *Av. Carlos Chagas Filho 373* *CCS, Bloco G, G1060 Ilha do Fundão* *Rio de Janei... περισσότερα »
Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media
Main ArticleAnti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis mediaA Tatara1 c1, M Korkmaza2, M Yaylaa3, M S Gozelera1, V Mutlua1, Z Halicia3, H Uslua4, H Korkmaza2 and J Sellia5 a1 Department of Otolaryngology, Head and Neck Surgery, Ataturk University Medical Faculty, Erzurum, Turkey a2 Department of Otolaryngology, Head and Neck Surgery, Ordu University Medical Faculty, Turkey a3 Department of Pharmacology, Ataturk University Medical Faculty, Erzurum, Turkey a4 Department of Microbiology, Ataturk University Medical Faculty, E... περισσότερα »
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx: *Condition*: Head and Neck Cancer *Intervention*: Radiation: dose escalation *Sponsor*: Cliniques universitaires Saint-Luc- Université Catholique de Louvain ArmsAssigned Interventions Experimental: Dose escalation Dose escalation Radiation: dose escalation molecular imaging based radiotherapy dose escalation Detailed Description:The objective is to assess the feasibility (i.e. early toxicity) of an adaptive dose escalation through 18F-FDG-PET-based dose painting by n... περισσότερα »
Nutrition and Quality of Life of Patients With Head and Neck Carcinoma After Radiotherapy
Nutrition and Quality of Life of Patients With Head and Neck Carcinoma After Radiotherapy: *Condition*: Head and Neck Cancer *Intervention*: Other: Regular dietary support *Sponsors*: University Hospital, Caen; University Hospital, Rouen; Centre Francois Baclesse Undernutrition in cancerology is frequent because it's present for thirty to fifty percent of the patients at the time of the diagnosis. According to the recommendations of the French Speaking Society of Clinical Nutrition and Metabolism (SFNEP) of November 2012, a five percent loss of weight compared to the pr... περισσότερα »
The Role of Voice Rest on Voice Outcomes Following Phonosurgery
The Role of Voice Rest on Voice Outcomes Following Phonosurgery: *Condition*: Unilateral Vocal Cord Lesions *Intervention*: Behavioral: Absolute Voice Rest *Sponsor*: Lawson Health Research Institute ArmsAssigned Interventions No Intervention: Control Patients in the control arm will undergo a graduated prescription of voice use immediately following surgery. Experimental: Absolute Voice Rest Patients in the experimental arm will undergo 7 days of absolute voice rest following surgery. Behavioral: Absolute Voice Rest Patients will be instructed to not use their voice and minim... περισσότερα »
Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer
Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer: *Condition*: Oropharyngeal Squamous Cell Cancer *Interventions*: Procedure: Neck Dissection; Procedure: Transoral Surgery of Primary Site; Radiation: Radiation; Drug: Carboplatin; Drug: Paclitaxel *Sponsor*: University of Michigan Cancer Center ArmsAssigned Interventions Experimental: Surgery Procedure: Neck Dissection All patients will undergo neck dissection. Procedure: Transoral Surgery of Pri... περισσότερα »
Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma
Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Drug: Docetaxel; Drug: Cisplatin 1; Drug: Xeloda; Radiation: IMRT; Drug: Cisplatin 2 *Sponsor*: Sun Yat-sen University ArmsAssigned Interventions Active Comparator: Group A low risk NPC treated with concurrent chemoradiotherapy Radiation: IMRT IMRT for all patients Drug: Cisplatin 2 Cisplatin 100mg/m2 in concurrent chemotherapy Other Name: DDP Active Comparator: Group B high risk NPC treated with concurre... περισσότερα »
An Emergency Presentation
Patients’ Experiences of Cancer Diagnosis as a Result of an Emergency Presentation: A Qualitative Study: by Georgia Black, Jessica Sheringham, Vicki Spencer-Hughes, Melanie Ridge, Mairead Lyons, Charlotte Williams, Naomi Fulop, Kathy Pritchard-Jones Introduction Cancers diagnosed following visits to emergency departments (ED) or emergency admissions (emergency presentations) are associated with poor survival and may result from preventable diagnostic delay. To improve outcomes for these patients, a better understanding is needed about how emergency presentations arise. This study... περισσότερα »
Moderate-to-severe obstructive sleep apnea is associated with subclinical myocardial injury and impaired hemodynamics in pulmonary hypertension patients
Moderate-to-severe obstructive sleep apnea is associated with subclinical myocardial injury and impaired hemodynamics in pulmonary hypertension patients: [image: sleep3062-fig-0001.sml] • Sleep apnea has a high prevalence in patients with pulmonary hypertension (PH).• PH patients with moderate-to-severe obstructive sleep apnea (OSA) had a higher pulmonary vascular resistance and lower cardiac index.• Moderate-to-severe OSA is an independent factor to determine serum troponin T level.• Moderate-to-severe OSA is associated with increased subclinical myocardial damage and abnormal... περισσότερα »
Use of FDG-PET Scan for the Assessment of Large Vessel Vasculitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Use of FDG-PET Scan for the Assessment of Large Vessel Vasculitis: Opinion statement Temporal artery biopsy will only detect (part of) the cranial forms of giant cell arteritis. For the large vessel variant of this type of vasculitis, FDG-PET is the technique of choice. Since treatment of large vessel vasculitis implies long-term treatment with steroids, […]
Relapsing drug-induced hypersensitivity syndrome.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Purpose of review: Drug-induced hypersensitivity syndrome (DIHS) is a serious adverse drug reaction with potential morbidity and mortality. ‘Flare up’ or relapses in DIHS is a rare but important feature. These relapses may occur within days to several weeks, even after discontinuation of the offending drug. In this article, we review the pathogenesis of DIHS, […]
Transforming the learning outcomes of anaesthesiology training into entrustable professional activities: A Delphi study.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
BACKGROUND: True competency-based medical education should produce graduates meeting fixed standards of competence. Current postgraduate programmes are usually based on a pre-determined length of time in training making them poorly suited for an individual approach. The concept of entrustable professional activities (EPAs) enables a more flexible, personalised and less time-dependent approach to training programmes. An […]
Survival after long-term isoflurane sedation in critically ill surgical patients.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1t7PTMg via IFTTT
Validation of a prediction model for post-discharge nausea and vomiting after general anaesthesia in a cohort of Swedish ambulatory surgery patients.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
BACKGROUND: In ambulatory surgery, post-discharge nausea and vomiting (PDNV) has been identified as a significant problem occurring in more than one-third of patients. OBJECTIVE: To validate a simplified PDNV score in a Swedish population. DESIGN: Prospective observational study. SETTING: Two county hospitals in Sweden: Sundsvall from June 2012 to May 2013 and Sunderbyn from January […]
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide hormones within its structure. These peptide hormones can be generated by cleavage of POMC at basic residue cleavage sites by prohormone-converting enzymes in the regulated secretory pathway (RSP) of POMC-synthesizing endocrine cells and neurons. The peptides are stored inside the cells in dense-core secretory granules […]
60 YEARS OF POMC: Purification and biological characterisation of melanotrophins and corticotrophins
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
The remarkable conservation of the primary structures and anatomical location of dogfish α-melanocyte-stimulating hormone (MSH), corticotrophin-like intermediate lobe peptide (CLIP) and adrenocorticotrophic hormone (ACTH) compared with mammals reinforced the tissue-specific processing hypothesis of ACTH peptides in the pituitary gland. The cloning of dogfish pro-opiomelanocortin (POMC) led to the identification of -MSH and simultaneously revealed the […]
60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis. After a brief summary of ACTH production from proopiomelanocortin (POMC) and on ACTH receptor properties, the first part of the review covers the role of ACTH in steroidogenesis and steroid secretion. […]
60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Many important fields of research had a humble origin. In the distant past, A J P Martin’s discovery that amino acids could be separated by paper chromatography and Moore and Stein’s use of columns for quantitative amino acid analysis provided the first steps towards the determination of structure in complex biologically active molecules. They opened […]
60 YEARS OF POMC: POMC: an evolutionary perspective
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: […]
Relapsing drug-induced hypersensitivity syndrome.
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Purpose of review: Drug-induced hypersensitivity syndrome (DIHS) is a serious adverse drug reaction with potential morbidity and mortality. ‘Flare up’ or relapses in DIHS is a rare but important feature. These relapses may occur within days to several weeks, even after discontinuation of the offending drug. In this article, we review the pathogenesis of DIHS, […]
Relapsing drug-induced hypersensitivity syndrome.
Purpose of review: Drug-induced hypersensitivity syndrome (DIHS) is a serious adverse drug reaction with potential morbidity and mortality. 'Flare up' or relapses in DIHS is a rare but important feature. These relapses may occur within days to several weeks, even after discontinuation of the offending drug. In this article, we review the pathogenesis of DIHS, implication of human herpesvirus 6 reactivation, and describe published case reports of patients with relapsing DIHS. Recent findings: Common drugs associated with DIHS include (but are not limited to) antiepileptics such as ca... περισσότερα »
Validation of a prediction model for post-discharge nausea and vomiting after general anaesthesia in a cohort of Swedish ambulatory surgery patients.
BACKGROUND: In ambulatory surgery, post-discharge nausea and vomiting (PDNV) has been identified as a significant problem occurring in more than one-third of patients. OBJECTIVE: To validate a simplified PDNV score in a Swedish population. DESIGN: Prospective observational study. SETTING: Two county hospitals in Sweden: Sundsvall from June 2012 to May 2013 and Sunderbyn from January to October 2014. PATIENTS: Adult patients undergoing ambulatory surgery under general anaesthesia. MAIN OUTCOME MEASURES: Postoperative outcomes with a focus on nausea and vomiting were collected at 2, 4... περισσότερα »
Relapsing drug-induced hypersensitivity syndrome.
Purpose of review: Drug-induced hypersensitivity syndrome (DIHS) is a serious adverse drug reaction with potential morbidity and mortality. 'Flare up' or relapses in DIHS is a rare but important feature. These relapses may occur within days to several weeks, even after discontinuation of the offending drug. In this article, we review the pathogenesis of DIHS, implication of human herpesvirus 6 reactivation, and describe published case reports of patients with relapsing DIHS. Recent findings: Common drugs associated with DIHS include (but are not limited to) antiepileptics such as ca... περισσότερα »
Behçet’s disease developing after poststreptococcal acute glomerulonephritis
A case of AbstractWe report a case of a 73-year-old Japanese male patient who developed Behçet’s disease (BD) after poststreptococcal acute glomerulonephritis. Three months after the initial presentation, acneiform eruption and oral and genital ulcers appeared. Treatment with oral prednisolone (20 mg/day) resulted in the remarkable disappearance of these symptoms. These findings support the hypothesis that *Streptococcus pyogenes* may be an etiologic factor of BD.
P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever
P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever: Abstract ObjectivesThis was a prospective controlled study to determine the P-wave duration (Pdu) and P-wave dispersion (Pd) in patients with familial Mediterranean fever (FMF). MethodsThe study group consisted of 26 children with uncomplicated FMF and 25 age- and sex-matched healthy controls. We performed electrocardiography (ECG) with Doppler echocardiography on patients and controls. All participants underwent 12-lead electrocardiography under strict standards. Pdu and Pd were compute... περισσότερα »
Systemic lupus erythematosus (SLE) with febrile neutropenia
A case of an SLE patient with febrile neutropenia who experienced exacerbation of cutaneous manifestations after the administration of G-CSF: AbstractSystemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Although hematological anomalies are commonly found in SLE, severe polymorphonuclear leukocyte depletion is rare. Most episodes of severe granulocytopenia in SLE patients tend to occur as part of drug toxicity-induced medullar hypoplasia, and recombinant human (rh) granulocyte colony-stimulating factor (G-CSF) has been shown to be effective for treating n... περισσότερα »
An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence of non-infectious illnesses and their risk factors and described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic in south east England. Patients age ≥50 years were invited to complete […]
Screening for asymptomatic lymphogranuloma venereum co-infection in men who have sex with men newly diagnosed with HIV, hepatitis C or syphilis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Patients diagnosed with lymphogranuloma venereum have high rates of co-infection with HIV, syphilis and hepatitis C. The aim of this enhanced surveillance was to screen all men who have sex with men (MSM) newly diagnosed with HIV, syphilis or hepatitis C for co-infection with asymptomatic lymphogranuloma venereum as part of the recommended sexual health screen. […]
A case of primary adrenal diffuse large B-cell lymphoma in HIV
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Primary adrenal diffuse large B-cell lymphoma in HIV is a very rare, highly aggressive extra-nodal lymphoma. There is only one previous case reported in the literature. Our patient presented with isolated bilateral adrenal masses with no lymphadenopathy or visceral involvement, which made the diagnosis challenging. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZwvB9P via IFTTT Medicine […]
HIV control in postpartum mothers: a turbulent time
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
We conducted an audit looking at the management of HIV-positive women in the postpartum period. We found that of the women with a previous AIDS-defining condition or a CD4 count <350 cells/µL, 83% were correctly continued on antiretroviral therapy (ART) and 84.1% of these had good virological control. ART was correctly stopped in 100% of […]
Impact of switching from lopinavir/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: the ATAzanavir & GLUcose metabolism (ATAGLU) study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Previous studies have reported that protease inhibitors (PIs) can contribute to glycaemic alterations. However, there are few trials examining the direct effect of a single PI. The objective of the study was to evaluate the modifications of glucose and lipid profiles after a switch from lopinavir/ritonavir (LPV/r) to atazanavir, used as ritonavir-boosted (ATV/r) or un-boosted. […]
Syphilis detection: evaluation of serological screening and pilot reverse confirmatory assay algorithm in blood donors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Serological assays are still considered the most useful tests in the diagnosis of syphilis. Since no single serological assay is able to provide a satisfactory result, in our laboratory we have evaluated the usefulness of a commercially-available immunoblot to diagnose syphilis infection among blood donors. From October 2012 to June 2013, 4572 blood donors were […]
Testing for latent tuberculosis infection using interferon gamma release assays in commercial sex workers at an outreach clinic in Birmingham
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
This report demonstrates that using interferon gamma release assays to screen for latent tuberculosis infection in female commercial sex workers in an outreach sexual health clinic is feasible and acceptable. Routine interferon gamma release assay use successfully identified high numbers of latent tuberculosis infection. Innovative approaches to treatment and follow up were required to improve […]
‘The waiting game: are current chlamydia and gonorrhoea near-patient/point-of-care tests acceptable to service users and will they impact on treatment?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
The objective of this study was to assess the length of time service users were prepared to wait for chlamydia and gonorrhoea (CT/GC) near-patient/point-of-care test (NP-POCT) results and to determine the possible effect on management. Individuals attending two UK clinics from November 2013 to February 2014 were surveyed asking the maximum length of time they […]
Total laparoscopic intestinal vaginoplasty as neovaginal reconstruction in an HIV-positive transgender woman
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
A 46-year-old, HIV-positive transgender woman of South American ethnicity consulted our outpatient clinic to discuss the possibilities of a surgical, secondary neovaginal reconstruction because of complete stenosis of her inverted penile skin-lined neovagina. She was taking abacavir/lamivudine and nevirapine as antiretroviral therapy. We successfully performed a total laparoscopic sigmoid vaginoplasty without any complications. There was […]
Intimate partner violence, partner notification, and expedited partner therapy: a qualitative study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Over one-third of women experience intimate partner violence (IPV) in their lifetime. IPV increases the risk of infection and re-infection with sexually transmitted infections (STIs). The extent to which health care providers consider IPV when recommending partner notification and expedited partner therapy is unknown. The objective of this qualitative study was to understand health care […]
Cognitive Effects of Stimulant, Guanfacine, and Combined Treatment in Child and Adolescent Attention-Deficit/Hyperactivity Disorder
Cognitive Effects of Stimulant, Guanfacine, and Combined Treatment in Child and Adolescent Attention-Deficit/Hyperactivity Disorder: Psychostimulants are partially effective in reducing cognitive dysfunction associated with attention-deficit/hyperactivity disorder (ADHD). Cognitive effects of guanfacine, an alternative treatment, are poorly understood. Given its distinct action on α2A receptors, guanfacine may have different or complementary effects relative to stimulants. This study tested stimulant and guanfacine monotherapies relative to combined treatment on cognitive functions ... περισσότερα »
Validation of the Acoustic Voice Quality Index in the Japanese Language
The Acoustic Voice Quality Index (AVQI) is a multivariate construct for quantification of overall voice quality based on the analysis of continuous speech and sustained vowel. The stability and validity of the AVQI is well established in several language families. However, the Japanese language has distinct characteristics with respect to several parameters of articulatory and phonatory physiology. The aim of the study was to confirm the criterion-related concurrent validity of AVQI, as well as its responsiveness to change and diagnostic accuracy for voice assessment in the Japanese... περισσότερα »
Validation of the Acoustic Voice Quality Index in the Japanese Language
Publication date: Available online 7 June 2016 *Source:*Journal of Voice Author(s): Kiyohito Hosokawa, Ben Barsties, Toshihiko Iwahashi, Mio Iwahashi, Chieri Kato, Shinobu Iwaki, Hisanori Sasai, Akira Miyauchi, Naoki Matsushiro, Hidenori Inohara, Makoto Ogawa, Youri Maryn ObjectivesThe Acoustic Voice Quality Index (AVQI) is a multivariate construct for quantification of overall voice quality based on the analysis of continuous speech and sustained vowel. The stability and validity of the AVQI is well established in several language families. However, the Japanese language has distinct... περισσότερα »
Transoral laser microsurgery for managing laryngeal stenosis after reconstructive partial laryngectomies
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Transoral laser microsurgery for managing laryngeal stenosis after reconstructive partial laryngectomies: Objectives/Hypothesis To retrospectively analyze our experience of transoral laser microsurgery (TLM) for treating postoperative laryngeal obstruction (POLO) after supracricoid and supratracheal laryngectomy (open partial horizontal laryngectomy [OPHL]) types 2 and 3, and to investigate potential relationships between patients’ clinical features and their functional outcomes. […]
Age-related changes in mastication are not improved by tongue exercise
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
in a rat model: Objectives/Hypothesis Aging results in progressive changes in deglutitive functions, which may be due in part to alterations in muscle morphology and physiology. Mastication is a critical component of bolus formation and swallowing, but aging effects on masticatory function have not been well studied. Study Design The purpose of this study was […]
5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition: Thyroid , Vol. 0, No. 0. Author information Juliana M. Cazarin, Raquel G. Coelho, Fabio Hecht, Bruno M. Andrade, and Denise P. Carvalho Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Address […]
Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Main Article Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media A Tatara1 c1, M Korkmaza2, M Yaylaa3, M S Gozelera1, V Mutlua1, Z Halicia3, H Uslua4, H Korkmaza2 and J Sellia5 a1 Department of Otolaryngology, Head and Neck Surgery, Ataturk University Medical Faculty, Erzurum, Turkey a2 Department of Otolaryngology, Head and Neck Surgery, Ordu University Medical Faculty, Turkey a3 Department of Pharmacology, Ataturk University […]
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx: Condition: Head and Neck Cancer Intervention: Radiation: dose escalation Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain Arms Assigned Interventions Experimental: Dose escalation Dose escalation Radiation: dose escalation molecular imaging based radiotherapy dose escalation Detailed Description:The objective is to assess the feasibility […]
Nutrition and Quality of Life of Patients With Head and Neck Carcinoma After Radiotherapy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Nutrition and Quality of Life of Patients With Head and Neck Carcinoma After Radiotherapy: Condition: Head and Neck Cancer Intervention: Other: Regular dietary support Sponsors: University Hospital, Caen; University Hospital, Rouen; Centre Francois Baclesse Undernutrition in cancerology is frequent because it’s present for thirty to fifty percent of the patients at the time of the diagnosis. According to the recommendations of the […]
The Role of Voice Rest on Voice Outcomes Following Phonosurgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The Role of Voice Rest on Voice Outcomes Following Phonosurgery: Condition: Unilateral Vocal Cord Lesions Intervention: Behavioral: Absolute Voice Rest Sponsor: Lawson Health Research Institute Arms Assigned Interventions No Intervention: Control Patients in the control arm will undergo a graduated prescription of voice use immediately following surgery. Experimental: Absolute Voice Rest Patients in the experimental arm will undergo 7 days of […]
Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer: Condition: Oropharyngeal Squamous Cell Cancer Interventions: Procedure: Neck Dissection; Procedure: Transoral Surgery of Primary Site; Radiation: Radiation; Drug: Carboplatin; Drug: Paclitaxel Sponsor: University of Michigan Cancer Center Arms Assigned Interventions Experimental: Surgery Procedure: Neck Dissection All patients will undergo neck dissection. Procedure: Transoral Surgery of […]
Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma: Condition: Nasopharyngeal Carcinoma Interventions: Drug: Docetaxel; Drug: Cisplatin 1; Drug: Xeloda; Radiation: IMRT; Drug: Cisplatin 2 Sponsor: Sun Yat-sen University Arms Assigned Interventions Active Comparator: Group A low risk NPC treated with concurrent chemoradiotherapy Radiation: IMRT IMRT for all patients Drug: Cisplatin 2 Cisplatin 100mg/m2 in […]
An Emergency Presentation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Patients’ Experiences of Cancer Diagnosis as a Result of an Emergency Presentation: A Qualitative Study: by Georgia Black, Jessica Sheringham, Vicki Spencer-Hughes, Melanie Ridge, Mairead Lyons, Charlotte Williams, Naomi Fulop, Kathy Pritchard-Jones Introduction Cancers diagnosed following visits to emergency departments (ED) or emergency admissions (emergency presentations) are associated with poor survival and may result from […]
Management of paediatric periorbital cellulitis: our experience of 243 children managed according to a standardised protocol 2012-2015
Paediatric periorbital cellulitis is a common condition. Accurate assessment can be challenging and appropriate use of CT imaging is essential. We audited admissions to our unit over a four year period, with reference to CT scanning and adherence to our protocol. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZwBR1h via IFTTT
Prevalence of hearing loss in children with with 22q11.2 deletion syndrome
The purpose of this study was to determine the prevalence and characterize the types of hearing loss in pediatric patients with 22q11.2 deletion syndrome (22q11DS). from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Ue93dy via IFTTT
Helicobacter pylori seroprevalence in children with sleep-disordered breathing
Chronic Helicobacter pylori (HP) infection is considered to be a factor involved in obstructive sleep apnea syndrome (OSAS). This cross-sectional study examined the seroprevalence of HP in children with sleep-disordered breathing (SDB) in respect to OSAS severity and in reference to other common pediatric medical conditions. from #Head and Neck by Sfakianakis via simeraentaxei on… Continue reading Helicobacter pylori seroprevalence in children with sleep-disordered breathing
Update on Local Allergic Rhinitis
We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of… Continue reading Update on Local Allergic Rhinitis
Helicobacter Pylori Detection and Clinical Symptomatology of Gastroesophageal Reflux Disease in Pediatric Patients with Otitis Media with Effusion
The study aimed to demonstrate H. pylori presence in otitis media with effusion (OME) and its association with symtomatology of gastroesophageal reflux disease (GERD). from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZwBDqS via IFTTT
Otitis media in children: a proposal for a new nosological classification
The authors declare that they have no conflict of interest. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Ue8YXo via IFTTT
Wideband reflectance in Down syndrome
Children with Down syndrome (DS) have a high incidence of middle ear disorders and congenital abnormalities of the external, middle and inner ear. Energy reflectance (ER), a wideband acoustic immittance (WAI) measurement parameter, can measure the sound energy reflected or absorbed in the ear canal over a wider range of frequencies more efficiently and faster… Continue reading Wideband reflectance in Down syndrome
Neutrophil to lymphocyte ratio in Bell’s palsy
Dear Editor, the recent report on “neutrophil to lymphocyte ratio (NLR) in Bell’s palsy” is very interesting [1]. Eryilmaz et al. noted that “NLR is recommended as a supportive parameter in the diagnosis of pediatric patients with Bell’s palsy [1].” It should be noted that NLR is not a specific laboratory parameter. There are several… Continue reading Neutrophil to lymphocyte ratio in Bell’s palsy
Radiologically-guided Balloon Sialoplasty for Treatment of Salivary Duct Stricture: A Novel Technique in Young Children
To describe our experience using radiologically-guided balloon sialoplasty to successfully treat sialadenitis in two children as a single modality intervention. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZwCd7Y via IFTTT
Quality improvement utilizing in-situ simulation for a dual-hospital pediatric code response team
Given the rarity of in-hospital pediatric emergency events, identification of gaps and inefficiencies in the code response can be difficult. In-situ, simulation-based medical education programs can identify unrecognized systems-based challenges. We hypothesized that developing an in-situ, simulation-based pediatric emergency response program would identify latent inefficiencies in a complex, dual-hospital pediatric code response system and allow… Continue reading Quality improvement utilizing in-situ simulation for a dual-hospital pediatric code response team
Age-related changes in mastication are not improved by tongue exercise
in a rat model: Objectives/Hypothesis Aging results in progressive changes in deglutitive functions, which may be due in part to alterations in muscle morphology and physiology. Mastication is a critical component of bolus formation and swallowing, but aging effects on masticatory function have not been well studied. Study Design The purpose of this study was to 1) quantify the effects of aging on mastication, and 2) determine the effects of tongue exercise on mastication in young adult and old rats. We hypothesized that there would be significant differences in mastication charact... περισσότερα »
Validation of the Acoustic Voice Quality Index in the Japanese Language
Publication date: Available online 7 June 2016 *Source:*Journal of Voice Author(s): Kiyohito Hosokawa, Ben Barsties, Toshihiko Iwahashi, Mio Iwahashi, Chieri Kato, Shinobu Iwaki, Hisanori Sasai, Akira Miyauchi, Naoki Matsushiro, Hidenori Inohara, Makoto Ogawa, Youri Maryn ObjectivesThe Acoustic Voice Quality Index (AVQI) is a multivariate construct for quantification of overall voice quality based on the analysis of continuous speech and sustained vowel. The stability and validity of the AVQI is well established in several language families. However, the Japanese language has distinct... περισσότερα »
Comparison of Antigenic Dominants of VP7 in G9 and G1 Rotavirus Strains Circulating in La Rioja, Argentina, with the Vaccine Strains
Viral Immunology , Vol. 0, No. 0. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1X9Il87
Comparison of asthma prevalence and morbidity among rural and nonrural youth
Characterizing the experience of pediatric asthma in rural communities is in a nascent stage. Rural youth can encounter barriers that place them at risk for asthma-related health disparities.1 They are also equally2,3 or more likely4 to be diagnosed as having asthma than youth in urban areas and can experience significant asthma morbidity.3–7 Previous studies have compared rural and urban youth residing in separate states,2 focused on a predominantly minority and low-income sample from a rural south delta region,5–7 or analyzed a Medicaid-only cohort of young rural children. from ... περισσότερα »
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