Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 40 δευτερόλεπτα
Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience: Abstract Introduction Choroidal melanoma (CM) is the most common primary ocular malignancy in adults. This study reviewed the Dunedin Hospital (DH) experience in the treatment of CM with stereotactic fractionated radiotherapy (SRT) and the outcome of prophylactic use of intravitreal injection bevacizumab (PIB) in preventing radiation retinopathy (RR). Methods A retrospective study was conducted of patients at DH who underwent SRT for ... περισσότερα »
Toxins, Vol. 8, Pages 206: Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 40 δευτερόλεπτα
Toxins, Vol. 8, Pages 206: Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells: Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties. Despite the recent promising news from the field of immunotherapy, there is an urgent need for new therapeutic approaches that are free of resistance mechanisms and side effects. Anti-neoplasic properties have been highlighted for different disintegrins from snake venom including Lebein; however, the exact effect of Lebein on mela... περισσότερα »
A new device for monitoring individual activity rhythms of honey bees reveals critical effects of the social environment on behavior
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 4 δευτερόλεπτα
Abstract Chronobiological studies of individual activity rhythms in social insects can be constrained by the artificial isolation of individuals from their social context. We present a new experimental set-up that simultaneously measures the temperature rhythm in a queen-less but brood raising mini colony and the walking activity rhythms of singly kept honey bees that have indirect social contact with it. Our approach enables monitoring of individual bees in the social context of a mini colony under controlled laboratory conditions. In a pilot experiment, we show that social contac... περισσότερα »
Toxins, Vol. 8, Pages 206: Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties. Despite the recent promising news from the field of immunotherapy, there is an urgent need for new therapeutic approaches that are free of resistance mechanisms and side effects. Anti-neoplasic properties have been […]
Obesity and associated lifestyles modify the effect of glucose metabolism-related genetic variants on impaired glucose homeostasis among postmenopausal women
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
ABSTRACT Purpose Impaired glucose metabolism-related genetic variants likely interact with obesity-modifiable factors in response to glucose intolerance, yet their interconnected pathways have not been fully characterized. Methods With data from 1,027 postmenopausal participants of the Genomics and Randomized Trials Network study and 15 single-nucleotide polymorphisms (SNPs) associated with glucose homeostasis, we assessed whether obesity, physical […]
Audit of CT reporting standards in cases of intracerebral haemorrhage at a comprehensive stroke centre in Australia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Abstract Introduction Multiple CT-derived biomarkers that are predictive of intracerebral haemorrhage (ICH) growth and outcome have been described in the literature, but the extent to which these appear in imaging reports of ICH is unknown. The aim of this retrospective process audit was to determine which of the known predictors of ICH outcome was recorded […]
Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Abstract Introduction Choroidal melanoma (CM) is the most common primary ocular malignancy in adults. This study reviewed the Dunedin Hospital (DH) experience in the treatment of CM with stereotactic fractionated radiotherapy (SRT) and the outcome of prophylactic use of intravitreal injection bevacizumab (PIB) in preventing radiation retinopathy (RR). Methods A retrospective study was conducted of […]
Diagnostic reference levels of paediatric computed tomography examinations performed at a dedicated Australian paediatric hospital
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Abstract Introduction Diagnostic Reference Levels (DRL) of procedures involving ionizing radiation are important tools to optimizing radiation doses delivered to patients and in identifying cases where the levels of doses are unusually high. This is particularly important for paediatric patients undergoing computed tomography (CT) examinations as these examinations are associated with relatively high-dose. Methods Paediatric […]
PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Abstract Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy […]
Head and Neck
*"HEAD AND NECK" TUMORS chemotherapy ]* An Introduction to a *Head and Neck Cancer*-Specific Frailty Index and Its Clinical Implications in Elderly Patients: A Prospective Observational Study Focusing on … M Kwon, SA Kim, JL Roh, SW Lee, SB Kim, SH Choi… - The Oncologist, 2016 *...* We investigated the clinical implications of a *head* *and* *neck* *cancer* (HNC)-specific frailty index suggested by prospective clinical and *...* Pretreatment performance status, VHI ≥8, MDADI <70, dental problems, and *chemotherapy* were significantly associated with early morbidity *...* [PDF] … AND ... περισσότερα »
Tumors of Ear
Lesions of Petrous Apex A Goyal - Clinico Radiological Series: Temporal Bone Imaging, 2016 *...* The most common site of cholesterol granuloma is *middle* *ear*, followed by *...* CECT image sinus window *in* a 50-year female patient with breast carcinoma shows aggressive lytic lesion (star) *in* left petrous apex with enhancing soft tissue, suggestive of *metastasis*. *...* *Metastases* (Fig *...* Recent Advances *in *Understanding the Pathogenesis of Acquired Cholesteatoma CL Kuo - Recent Advances *in *Otolaryngology Head & Neck …, 2016 *...* 2-4 given that it consists of a well-de... περισσότερα »
HPV
[PDF] από researchgate.net Inhibitory effect of 1-MCP on ripening and superficial scald development in & #39;McIntosh'and 'Delicious' apples *HPV *Rupasinghe, DP Murr, G Paliyath… - The Journal of …, 2000 - Taylor & Francis Summary 'McIntosh'and 'Delicious' apple were treated with the competitive ethylene (C2H4) antagonist 1-methylcyclopropene (1-MCP), to evaluate its feasibility as a postharvest tool for use by the apple industry. The threshold concentration of 1-MCP required to inhibit de *...* Γίνεται αναφορά σε 241 Σχετικά άρθρα Όλες οι 3 εκδοχές Παράθεση Αποθήκευση [PDF] από uta.fi E... περισσότερα »
Rapid detection of human papillomavirus genotype 16 (HPV-16)
[PDF] by loop-mediated isothermal amplification (LAMP) NI Hamzan, NA Rahman, SSM Noor, S Mohamad *...* 5) Saini, R., Tang, T.-H., Zain, R., Cheong, S., Musa, K., Saini, D., Ismail, A., Abraham, M., Mustafa, W. & Santhanam, J. (2011). Significant association of high-risk *human* *papillomavirus* (*HPV*) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia. *...*
Immunotherapy
Targeted *immunotherapy *using anti-CD138-interferon α fusion proteins and bortezomib results in synergistic protection against multiple myeloma A Vasuthasawat, EM Yoo, KR Trinh, A Lichtenstein… - mAbs, 2016 Abstract Although recent advances have substantially improved the management of multiple myeloma, it remains an incurable malignancy. We now demonstrate that anti-CD138 molecules genetically fused to type I interferons (IFN) synergize with the approved *...* [HTML] Oral *Immunotherapy *for Food Allergies E Feuille, A Nowak-Węgrzyn - Annals of Nutrition and Metabolism, 2016 Abstra... περισσότερα »
Acoustic Transmission Characteristics of a Eustachian Tube
Volitionally Opened in Two Living Subjects. Y Amoako-Tuffour, N Jufas, J Quach, L Le, G Earle… - Otology & Neurotology, 2016 Objective: To assess the acoustic transmission characteristics of the *Eustachian tube *(ET) in living subjects in verified patent and closed ET states to facilitate the detection and quantification of ET function using acoustic measures such as sonotubometry.
Micro-ribonucleic acids
[PDF] EPAS1 Promotes Endothelial Cell Migration in an IRX3-Dependent Manner PK Barnett - 2016 *...* mir-145 *Micro*-*ribonucleic* *acid* 145 mir-146 *Micro*-*ribonucleic* *acid* 146 *miRNA**Micro*-*ribonucleic* *acid* *miRNA*-125 *Micro*-*ribonucleic* *acid* 125 MMP Matrix metallo-proteinase MOPS 3-(N-Morpholino)propanesulfonic *acid* mRNA Messenger ribonucleic *acid* *...*
Rhinosinusitis
Immunoglobulins Concentrations in Patients with Chronic *Rhinosinusitis* SA Madani, SA Hashemi, M Fazli, EH Kerdabadi - International Journal of medicine …, 2016 Abstract Background and objective; It seems local secretory or systemic humoral immunodeficiency predisposes the individuals to *rhinosinusitis*. Although immunodeficiency was a subject of various researches but studies indicate it is a fertile subject of *...* Asthma associated with chronic *rhinosinusitis*: a population‐based study YT Chen, CY Chien, SY Tai, CM Huang, CTC Lee - International Forum of Allergy & …, 2016 Bac... περισσότερα »
Mastoid Cavity Obliteration with Bioactive Glass Granules
Mastoid Cavity Obliteration with Bioactive Glass Granules G Schimanski, E Schimanski - Recent Advances in Otolaryngology Head & Neck …, 2016 Page 270. Chapter 15 Mastoid Cavity Obliteration with Bioactive Glass Granules Goesta Schimanski, Esther Schimanski INTRODUCTION Mastoid cavities are generally formed during cholesteatoma surgery with the aim to get *...*
Neck Dissection
Modified Radical Neck Dissection DV Bann, B Oberman, D Goldenberg - … Techniques in Otolaryngology-Head & Neck …, 2016 *...* of lymph nodes at highest risk for metastasis (see Chapter 18: *Selective* *Neck* Dissection *...* is a minimally invasive interventional radiology procedure that can effectively *treat* chyle leak *...* Alternatively, thoracoscopic ligation of the thoracic duct also provides effective *treatment* for high *...* Squamous cell carcinoma of unknown primary tumor metastatic to neck nodes: role of elective irradiation P Strojan, M Kokalj, V Zadnik, A Aničin, G Pla... περισσότερα »
Actinic keratosis
… of daylight photodynamic therapy with methyl aminolevulinate cream versus diclofenac plus hyaluronic acid gel for the treatment of multiple *actinic keratosis* P Calzavara-Pinton, C Zane, M Pacou, RM Szeimies - European Journal of …, 2016 Background: *Actinic keratosis *(AK) is a pre-cancerous condition characterised by patches of thick, scaly skin developing on sun-exposed areas of the body. When multiple AKs develop on severely photodamaged skin, commonly used treatments include photodynamic *...* Squamous cell carcinoma and severe photosensitivity reaction progressing to exten... περισσότερα »
Artificial Olfaction
[PDF] “HOW FILMS SHOULD SMELL”: STUDY OF *OLFACTION *IN FILMS IN DRAMATICAL CONTEXT FY Koroglu ABSTRACT The dream of introducing olfactory stimuli to cinema has its root way back in the history of films, even older in the roots of drama. As an audiovisual medium, cinema is considered quite well-doing on recreation of basic reality and experience of stories on two *...* Major Urinary Proteins on Nanodiamond Based Resonators Towards Artificial *Olfaction* E Scorsone, R Manai, M Ricatti, M Redaelli… Urinary Proteins (MUPS) from the mouse as chemical recognition elements has been develo... περισσότερα »
Nonpharmacological Methods to Minimize Salivary Gland Damage after Radioiodine Therapy
[PDF] Clinical Studies of Nonpharmacological Methods to Minimize *Salivary *Gland Damage after Radioiodine Therapy of Differentiated Thyroid *Carcinoma*: Systematic … A Christou, E Papastavrou, A Merkouris, S Frangos… - … -Based Complementary and …, 2016 Purpose. To systematically review clinical studies examining the effectiveness of nonpharmacological methods to prevent/minimize *salivary *gland damage due to radioiodine treatment of differentiated thyroid *carcinoma *(DTC). Methods. Reports on relevant trials *...*
Hearing
[PDF] ROLE OF AUDIOLOGICAL SCREENING (PURE TONE AUDIOMETRY AND DISTORTION PRODUCT OTOACOUSTIC EMISSIONS) IN PATIENTS UNDERGOING … A Kocchar, R Sharma, P Kumar, V Sharma… - SRMS Journal of Medical …, 2016 *...* 1. *Dr*. KJ Shinde, *Dr*. Syed Imdad Husain Hashmi *...* 8. Rajesh Dikshit, Prakash C Gupta, Chinthanie Ramasundarahettige, Vendhan, Gajalakshmi, Lukasz Aleksandrowicz, *Rajendra* *Badwe*, Rajesh Kumar, Sandip Roy, Wilson Suraweera, Freddie Bray, Mohandas Mallath, Poonam *...*
Toxins, Vol. 8, Pages 206: Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties. Despite the recent promising news from the field of immunotherapy, there is an urgent need for new therapeutic approaches that are free of resistance mechanisms and side effects. Anti-neoplasic properties have been… Continue reading Toxins, Vol. 8, Pages 206: Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
Obesity and associated lifestyles modify the effect of glucose metabolism-related genetic variants on impaired glucose homeostasis among postmenopausal women
ABSTRACT Purpose Impaired glucose metabolism-related genetic variants likely interact with obesity-modifiable factors in response to glucose intolerance, yet their interconnected pathways have not been fully characterized. Methods With data from 1,027 postmenopausal participants of the Genomics and Randomized Trials Network study and 15 single-nucleotide polymorphisms (SNPs) associated with glucose homeostasis, we assessed whether obesity, physical… Continue reading Obesity and associated lifestyles modify the effect of glucose metabolism-related genetic variants on impaired glucose... περισσότερα »
Audit of CT reporting standards in cases of intracerebral haemorrhage at a comprehensive stroke centre in Australia
Abstract Introduction Multiple CT-derived biomarkers that are predictive of intracerebral haemorrhage (ICH) growth and outcome have been described in the literature, but the extent to which these appear in imaging reports of ICH is unknown. The aim of this retrospective process audit was to determine which of the known predictors of ICH outcome was recorded… Continue reading Audit of CT reporting standards in cases of intracerebral haemorrhage at a comprehensive stroke centre in Australia
Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience
Abstract Introduction Choroidal melanoma (CM) is the most common primary ocular malignancy in adults. This study reviewed the Dunedin Hospital (DH) experience in the treatment of CM with stereotactic fractionated radiotherapy (SRT) and the outcome of prophylactic use of intravitreal injection bevacizumab (PIB) in preventing radiation retinopathy (RR). Methods A retrospective study was conducted of… Continue reading Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience
Diagnostic reference levels of paediatric computed tomography examinations performed at a dedicated Australian paediatric hospital
Abstract Introduction Diagnostic Reference Levels (DRL) of procedures involving ionizing radiation are important tools to optimizing radiation doses delivered to patients and in identifying cases where the levels of doses are unusually high. This is particularly important for paediatric patients undergoing computed tomography (CT) examinations as these examinations are associated with relatively high-dose. Methods Paediatric… Continue reading Diagnostic reference levels of paediatric computed tomography examinations performed at a dedicated Australian paediatric hospital
An electronic interface to routinize outcomes assessment and streamline clinic workflow
from #ENT via xlomafota13 on Inoreader http://ift.tt/29mUhRm via IFTTT
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. Study Design Prospective, multicenter, observational cohort. Methods Patients with CRS were enrolled between April 2011 and September 2015. Patients with sinonasal mucocele or unilateral sin... περισσότερα »
Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
Objectives/Hypothesis Determine predictive patient characteristics that guide the decision to proceed with surgical management of tongue-based airway obstruction (TBAO) in Pierre Robin sequence (PRS) patients. Study Design Retrospective review of PRS patients between 2005 and 2014 requiring observation in the neonatal intensive care unit (NICU). Methods Patient charts were reviewed for prenatal diagnoses, clinical course, and need for surgical intervention (tracheotomy or mandibular distraction osteogenesis), and the nonsurgical and surgical group were compared with a logistic ... περισσότερα »
Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
Objectives/Hypothesis Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three-dimensional configurational changes of the vocal fold medial surface. Study Design In vivo canine hemilarynx model. Methods A hemilaryngectomy was performed in an in vivo canine model and ink was used to... περισσότερα »
Transoral robotic surgery in the seated position: Rethinking our operative approach
Objectives/Hypothesis Transoral surgery (TOS) is commonly performed in a supine patient with an oral retractor. Paradoxically, this strategy can create difficulty with visualizing and accessing pathology at the base of tongue, inferior pharynx, and larynx. We investigate the feasibility of TOS with the patient in the seated position. Study Design Pilot study. Methods TOS utilizing the da Vinci Robotic Surgical Xi and Si systems (Intuitive Surgical, Sunnyvale, CA) was performed on a fresh cadaver placed in both the traditional supine position and the seated position. Transoral r... περισσότερα »
Low-grade myofibroblastic sarcoma: A population-based study
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics. Study Design Retrospective database analysis. Methods A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between 2001 and 2012. Results There were 49 cases with a 5-year overall survival of 71.6% and disease- specific survival of 76.3%. ... περισσότερα »
Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To obtain actual status of age-related hearing loss in a general unscreened population of older Dutch adults and to investigate whether the prevalence or degree has changed over time. Study Design To investigate the prevalence and degree of hearing loss, we conducted a large prospective cohort study of older adults between February 2011 and July 2015. Methods Pure-tone air- and bone-conduction thresholds were measured for 4,743 participants. Results were compared to previous cohort studies. Results As exp... περισσότερα »
Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation
Objectives/Hypothesis To establish the rate of inflammatory reaction to hyaluronic acid (HA) in vocal fold injection augmentation, determine the most common presenting signs and symptoms, and propose an etiology. Study Design Retrospective chart review. Methods Patients injected with HA over a 5-year period were reviewed to identify those who had a postoperative inflammatory reaction. Medical records were reviewed for patient demographic information, subjective complaints, Voice Handicap Index-10 (VHI-10) scores, medical intervention, and resolution time. Videolaryngostroboscop... περισσότερα »
An electronic interface to routinize outcomes assessment and streamline clinic workflow
from #ENT via xlomafota13 on Inoreader http://ift.tt/29mUhRm via IFTTT
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. Study Design Prospective, multicenter, observational cohort. Methods Patients with CRS were enrolled between April 2011 and September 2015. Patients with sinonasal mucocele or unilateral sin... περισσότερα »
Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor
Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient's old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions. from #ENT via xlomafota13 on Inoreader http://ift.tt/29iqtHV via IFTTT
Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
Objectives/Hypothesis Determine predictive patient characteristics that guide the decision to proceed with surgical management of tongue-based airway obstruction (TBAO) in Pierre Robin sequence (PRS) patients. Study Design Retrospective review of PRS patients between 2005 and 2014 requiring observation in the neonatal intensive care unit (NICU). Methods Patient charts were reviewed for prenatal diagnoses, clinical course, and need for surgical intervention (tracheotomy or mandibular distraction osteogenesis), and the nonsurgical and surgical group were compared with a logistic ... περισσότερα »
Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
Objectives/Hypothesis Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three-dimensional configurational changes of the vocal fold medial surface. Study Design In vivo canine hemilarynx model. Methods A hemilaryngectomy was performed in an in vivo canine model and ink was used to... περισσότερα »
Transoral robotic surgery in the seated position: Rethinking our operative approach
Objectives/Hypothesis Transoral surgery (TOS) is commonly performed in a supine patient with an oral retractor. Paradoxically, this strategy can create difficulty with visualizing and accessing pathology at the base of tongue, inferior pharynx, and larynx. We investigate the feasibility of TOS with the patient in the seated position. Study Design Pilot study. Methods TOS utilizing the da Vinci Robotic Surgical Xi and Si systems (Intuitive Surgical, Sunnyvale, CA) was performed on a fresh cadaver placed in both the traditional supine position and the seated position. Transoral r... περισσότερα »
Low-grade myofibroblastic sarcoma: A population-based study
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics. Study Design Retrospective database analysis. Methods A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between 2001 and 2012. Results There were 49 cases with a 5-year overall survival of 71.6% and disease- specific survival of 76.3%. ... περισσότερα »
Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To obtain actual status of age-related hearing loss in a general unscreened population of older Dutch adults and to investigate whether the prevalence or degree has changed over time. Study Design To investigate the prevalence and degree of hearing loss, we conducted a large prospective cohort study of older adults between February 2011 and July 2015. Methods Pure-tone air- and bone-conduction thresholds were measured for 4,743 participants. Results were compared to previous cohort studies. Results As exp... περισσότερα »
Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation
Objectives/Hypothesis To establish the rate of inflammatory reaction to hyaluronic acid (HA) in vocal fold injection augmentation, determine the most common presenting signs and symptoms, and propose an etiology. Study Design Retrospective chart review. Methods Patients injected with HA over a 5-year period were reviewed to identify those who had a postoperative inflammatory reaction. Medical records were reviewed for patient demographic information, subjective complaints, Voice Handicap Index-10 (VHI-10) scores, medical intervention, and resolution time. Videolaryngostroboscop... περισσότερα »
An electronic interface to routinize outcomes assessment and streamline clinic workflow
from #ENT via xlomafota13 on Inoreader http://ift.tt/29mUhRm via IFTTT
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. Study Design Prospective, multicenter, observational cohort. Methods Patients with CRS were enrolled between April 2011 and September 2015. Patients with sinonasal mucocele or unilateral sin... περισσότερα »
Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor
Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient's old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions. from #ENT via xlomafota13 on Inoreader http://ift.tt/29iqtHV via IFTTT
A miniaturized electrochemical device integrating biconical microchannel and carbon fiber disk ultramicroelectrode
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN01205A, Communication Fengxia Chang, Xia Xie, Meixian Li , Zhiwei Zhu A simple, cheap and available miniaturized electrochemical device based on the biconical microchannel was developed, with which only 1 [small mu ]L sample solution was needed to implement a typical electrochemical experiment.... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29t9jal via IFTTT
Visible-light driven photoelectrochemical immunosensor for insulin detection based on MWCNTs@SnS2@CdS nanocomposites
[image: S09565663.gif] Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Yixin Liu, Yifeng Zhang, Dan Wu, Dawei Fan, Xuehui Pang, Yong Zhang, Hongmin Ma, Xu Sun, Qin Wei In this work, a label-free photoelectrochemical (PEC) immunosensor was developed for ultrasensitive detection of insulin based on MWCNTs@SnS2@CdS nanocomposites. As graphene-like 2D nanomaterial, SnS2 nanosheets loaded on the conducting framework of multi-walled carbon nanotubes (MWCNTs) were adopted for the construction of immunosensor for the first time, providing a fa... περισσότερα »
A ratiometric fluorescence RRE RNA-targeted assay for a new fluorescence ligand
[image: S09565663.gif] Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Liang Qi, Jing-Ru Wei, Xiao-Jun Lv, Yuan Huo, Zhi-Qi Zhang The Rev protein regulates HIV-1 gene expression. Small ligands that bind to the Rev response element (RRE) RNA would inhibit Rev function and suppress HIV-1 replication. A novel ratiometric fluorescence assay was applied in the present study to monitor ligand-RNA interactions by using red-emitting CdTe quantum dots (QDs) coated with silica as a reference. A small fluorescence ligand, ICR 191, was found to int... περισσότερα »
A label-free photoelectrochemical aptasensor for bisphenol A based on surface plasmon resonance of gold nanoparticle-sensitized ZnO nanopencils
[image: S09565663.gif] Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Yunfei Qiao, Jing Li, Hongbo Li, Hailin Fang, Dahe Fan, Wei Wang A simple and novel photoelectrochemical (PEC) aptasensor for selective detection of bisphenol A (BPA) was developed using surface plasmon resonance of Au nanoparticles activated ZnO nanopencils. With the irradiation of simulated light, the increased photocurrent of nano-Au/ZnO than that of pure ZnO nanopencil is induced by the hot electrons from excited Au nanoparticles. The perfect selectivity is attri... περισσότερα »
Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays
Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Diana Seidel, Janine Obendorf, Beate Englich, Heinz-Georg Jahnke, Vesselina Semkova, Simone Haupt, Mathilde Girard, Marc Peschanski, Oliver Brüstle, Andrea A. Robitzki In today's neurodevelopment and -disease research, human neural stem/progenitor cell-derived networks represent the sole accessible in vitro model possessing a primary phenotype. However, cultivation and moreover, differentiation as well as maturation of human neural stem/progenitor cells are very complex and time-consuming... περισσότερα »
Highly sensitive sandwich-type SPR based detection of whole H5Nx viruses using a pair of aptamers
[image: S09565663.gif] Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Van-Thuan Nguyen, Ho Bin Seo, Byoung Chan Kim, Sang Kyung Kim, Chang-Seon Song, Man Bock Gu In this research, we report highly sensitive and specific sandwich-type SPR-based biosensor for the detection H5Nx whole viruses. A few of aptamers, for the first time, were successfully screened and characterized for whole avian influenza (AI) viruses, H5Nx, by using Multi-GO-SELEX method. The affinities of the aptamers developed in this study were ranged from 8×104 to 1×104... περισσότερα »
Contents
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Publication date: June 2016 Source:Radiotherapy and Oncology, Volume 119, Issue 3 } http://ift.tt/29n1kt1
PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Abstract Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy […]
A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Summary Mal de Meleda (MDM) is a palmoplantar keratoderma (PPK), characterized by hyperkeratosis of the palms and soles, and keratotic skin lesions. Patients with MDM can develop perioral erythema, keratotic and lichenoid plaques over the joints (including the elbows and knees), nail abnormalities, joint contractures and stiffness, brachydactyly, sclerodactyly, pseudoainhum, and malodorous maceration. MDM is […]
Dermoscopy and direct immunofluorescence findings of elastosis perforans serpiginosa
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Summary Elastosis perforans serpiginosa (EPS) is a rare skin disorder characterized by transepidermal elimination of abnormal elastic fibres. We present a new case of D-penicillamine (DPA)-induced EPS, and describe the clinical, dermoscopic, histopathological and direct immunofluorescence (DIF) findings. A 33-year-old woman receiving treatment with DPA presented with annular skin lesions. Digital dermoscopy of the lesions […]
Alterations of p14 ARF , p15 INK4b , and p16 INK4a Genes in Primary Laryngeal Squamous Cell Carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Abstract The 9p21 gene cluster, harboring growth suppressive genes p14 ARF , p15 INK4b , and p16 INK4a , is one of the major aberration hotspots in head and neck cancers. We try to elucidate specific aberrations affecting this region, throughout methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay. Methylation of the gene was investigated by […]
Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Objectives/Hypothesis Determine predictive patient characteristics that guide the decision to proceed with surgical management of tongue-based airway obstruction (TBAO) in Pierre Robin sequence (PRS) patients. Study Design Retrospective review of PRS patients between 2005 and 2014 requiring observation in the neonatal intensive care unit (NICU). Methods Patient charts were reviewed for prenatal diagnoses, clinical course, […]
Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Objectives/Hypothesis Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three-dimensional […]
Transoral robotic surgery in the seated position: Rethinking our operative approach
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Objectives/Hypothesis Transoral surgery (TOS) is commonly performed in a supine patient with an oral retractor. Paradoxically, this strategy can create difficulty with visualizing and accessing pathology at the base of tongue, inferior pharynx, and larynx. We investigate the feasibility of TOS with the patient in the seated position. Study Design Pilot study. Methods TOS utilizing […]
Low-grade myofibroblastic sarcoma: A population-based study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Objectives/Hypothesis Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics. Study Design Retrospective database analysis. Methods A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between […]
Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Objectives/Hypothesis To obtain actual status of age-related hearing loss in a general unscreened population of older Dutch adults and to investigate whether the prevalence or degree has changed over time. Study Design To investigate the prevalence and degree of hearing loss, we conducted a large prospective cohort study of older adults between February 2011 and […]
IJMS, Vol. 17, Pages 1072: Staphylococcal Superantigen-Like Protein 1 and 5 (SSL1 & SSL5) Limit Neutrophil Chemotaxis and Migration through MMP-Inhibition
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Matrix metalloproteinases (MMPs) are endopeptidases that degrade components of the extracellular matrix, but also modulate inflammation. During bacterial infections, MMPs are important in the recruitment and migration of inflammatory cells. Besides facilitating cell migration by degrading extracellular matrix components, they potentiate the action of several inflammatory molecules, including cytokines, chemokines, and antimicrobial peptides. Staphylococcus aureus […]
IJMS, Vol. 17, Pages 1074: Molecular Targeted Therapies for the Treatment of Leptomeningeal Carcinomatosis: Current Evidence and Future Directions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Leptomeningeal carcinomatosis (LMC) is the multifocal seeding of cerebrospinal fluid and leptomeninges by malignant cells. The incidence of LMC is approximately 5% in patients with malignant tumors overall and the rate is increasing due to increasing survival time of cancer patients. Eradication of the disease is not yet possible, so the treatment goals of LMC […]
Turtle herpes outbreak hints at Great Barrier Reef contamination
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Tumours linked to herpesvirus are increasingly affecting some populations of turtles in Australia and Florida – and pollution may be the cause from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29jTLEb via IFTTT
IJERPH, Vol. 13, Pages 682: Evaluation of the Effectiveness of Tai Chi versus Brisk Walking in Reducing Cardiovascular Risk Factors: Protocol for a Ranomized Controlled Trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Physical inactivity is one of the major modifiable lifestyle risk factors for cardiovascular disease (CVD). This protocol aims to evaluate the effectiveness of Tai Chi versus brisk walking in reducing CVD risk factors. This is a randomized controlled trial with three arms, namely, Tai Chi group, walking group, and control group. The Tai Chi group […]
Turtle herpes outbreak hints at Great Barrier Reef contamination
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Tumours linked to herpesvirus are increasingly affecting some populations of turtles in Australia and Florida – and pollution may be the cause from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29jTLEb via IFTTT
IJMS, Vol. 17, Pages 1038: Natural Bioactive Compounds: The Way Shown by Professor Maurizio Battino and His Group in an Italian Cutting-Edge Laboratory
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projects and Master courses at FUNIBER on-line platform (Barcelona, Spain).[…] from #AlexandrosSfakianakis […]
HCP? Just 6 more days to contribute to this crucial @UKlungcancer survey https://t.co/b5SYGWAKvW https://t.co/uXNBSYkvia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
HCP? Just 6 more days to contribute to this crucial @UKlungcancer survey https://t.co/b5SYGWAKvW https://t.co/uXNBSYkvia from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/750240350355222528 via IFTTT
Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Background Pain is a common adverse effect during dermatological laser procedures. Currently, no standard topical anaesthetic cream exists for deeper dermal laser procedures. Objective To compare the efficacy of lidocaine/tetracaine cream and lidocaine/prilocaine cream in reducing self-reported pain during deeper dermal laser treatments of acne keloidalis nuchae (AKN) and tattoos. Methods We conducted two […]
Comparing survival of patients with single or multiple primary melanoma in The Netherlands: 1994-2009
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract In the Netherlands the incidence of melanoma has been increasing whilst melanoma survival has improved significantly in the last 20 years1. As a result, there is an increasing number of melanoma survivors, who are at increased risk of developing new melanomas2. There is limited and conflicting literature concerning the survival of patients with multiple […]
Clinical Evaluation of Local Hyperthermia at 44°C for Mollusca Contagiosa: Pilot study with 21 patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Molluscum contagiosum (MC) is a common cutaneous viral infection caused by Molluscipoxvirus and featured by single or multiple pearly, usually umbilicated papular lesions on the surface of skin or mucosa. The benign infection is highly contagious and primarily affects pre-adolescent children and young, sexually active adults.1 According to a recent cohort study, the mean […]
In Vivo Table of Contents for July-August 2016; Vol. 30, No. 4
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
HOME CURRENT ISSUE PAST ISSUES SUBSCRIBE ALERTS IIAR JOURNALS CONFERENCES CONTACT US HELP In Vivo July-August 2016; 30 (4)
On the distribution of intranuclear and cytoplasmic aggregates in the brainstem of patients with spinocerebellar ataxia type 2 and 3
Abstract The polyglutamine (polyQ) diseases are a group of genetically and clinically heterogeneous neurodegenerative diseases, characterized by the expansion of polyQ sequences in unrelated disease proteins, which form different types of neuronal aggregates. The aim of this study was to characterise the aggregation pathology in the brainstem of spinocerebellar ataxia type 2 (SCA2) and 3 (SCA3) patients. For good recognition of neurodegeneration and rare aggregates, we employed 100 µm PEG embedded brainstem sections, which were immunostained with the 1C2 antibody, targeted at poly... περισσότερα »
Tau pathology in Creutzfeldt-Jakob disease revisited
Abstract Creutzfeldt-Jakob disease (CJD) is a human prion disease with different etiologies. To determine the spectrum of tau pathologies in CJD we assessed phospho-Tau (pTau) immunoreactivities in 75 sporadic CJD cases including an evaluation of the entorhinal cortex and six hippocampal subregions. 12 cases (16%) showed only small tau-immunoreactive neuritic profiles. 52 (69.3%) showed additional tau pathology in the medial temporal lobe compatible with primary age related tauopathy (PART). In 22/52 cases the lower pTau immunoreactivity load in the entorhinal cortex as compared to... περισσότερα »
On the distribution of intranuclear and cytoplasmic aggregates in the brainstem of patients with spinocerebellar ataxia type 2 and 3
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Abstract The polyglutamine (polyQ) diseases are a group of genetically and clinically heterogeneous neurodegenerative diseases, characterized by the expansion of polyQ sequences in unrelated disease proteins, which form different types of neuronal aggregates. The aim of this study was to characterise the aggregation pathology in the brainstem of spinocerebellar ataxia type 2 (SCA2) and 3 (SCA3) patients. For good recognition of neurodegeneration and rare aggregates, we employed 100 µm PEG embedded brainstem sections, which were immunostained with the 1C2 antibody, targeted at poly... περισσότερα »
Tau pathology in Creutzfeldt-Jakob disease revisited
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Abstract Creutzfeldt-Jakob disease (CJD) is a human prion disease with different etiologies. To determine the spectrum of tau pathologies in CJD we assessed phospho-Tau (pTau) immunoreactivities in 75 sporadic CJD cases including an evaluation of the entorhinal cortex and six hippocampal subregions. 12 cases (16%) showed only small tau-immunoreactive neuritic profiles. 52 (69.3%) showed additional tau pathology in the medial temporal lobe compatible with primary age related tauopathy (PART). In 22/52 cases the lower pTau immunoreactivity load in the entorhinal cortex as compared to... περισσότερα »
IJERPH, Vol. 13, Pages 682: Evaluation of the Effectiveness of Tai Chi versus Brisk Walking in Reducing Cardiovascular Risk Factors: Protocol for a Ranomized Controlled Trial
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Physical inactivity is one of the major modifiable lifestyle risk factors for cardiovascular disease (CVD). This protocol aims to evaluate the effectiveness of Tai Chi versus brisk walking in reducing CVD risk factors. This is a randomized controlled trial with three arms, namely, Tai Chi group, walking group, and control group. The Tai Chi group […]
IJMS, Vol. 17, Pages 1038: Natural Bioactive Compounds: The Way Shown by Professor Maurizio Battino and His Group in an Italian Cutting-Edge Laboratory
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projects and Master courses at FUNIBER on-line platform (Barcelona, Spain).[…] from #ORL-AlexandrosSfakianakis […]
HCP? Just 6 more days to contribute to this crucial @UKlungcancer survey https://t.co/b5SYGWAKvW https://t.co/uXNBSYkvia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
HCP? Just 6 more days to contribute to this crucial @UKlungcancer survey https://t.co/b5SYGWAKvW https://t.co/uXNBSYkvia from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/750240350355222528 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Far-red light photoacclimation: Chromophorylation of FR induced α- and β-subunits of allophycocyanin from Chroococcidiopsis thermalis sp. PCC7203
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Qian-Zhao Xu, Jia-Xin Han, Qi-Ying Tang, Wen-Long Ding, Dan Miao, Ming Zhou, Hugo Scheer, Kai-Hong Zhao Cyanobacterial light-harvesting complexes, phycobilisomes, can undergo extensive remodeling under varying light conditions. Acclimation to far-red light involves not only generation of red-shifted chlorophylls […]
Water exit pathways and proton pumping mechanism in B-type cytochrome c oxidase from molecular dynamics simulations
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Longhua Yang, Åge A. Skjevik, Wen-Ge Han Du, Louis Noodleman, Ross C. Walker, Andreas W. Götz Cytochrome c oxidase (CcO) is a vital enzyme that catalyzes the reduction of molecular oxygen to water and pumps protons across mitochondrial and […]
Effect of ionic strength on intra-protein electron transfer reactions: The case study of charge recombination within the bacterial reaction center
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Mauro Giustini, Matteo Parente, Antonia Mallardi, Gerardo Palazzo It is a common believe that intra-protein electron transfer (ET) involving reactants and products that are overall electroneutral are not influenced by the ions of the surrounding solution. The results presented […]
The strontium inorganic mutant of the water oxidizing center (CaMn4O5) of PSII improves WOC efficiency but slows electron flux through the terminal acceptors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Colin Gates, Gennady Ananyev, G. Charles Dismukes Herein we extend prior studies of biosynthetic strontium replacement of calcium in PSII-WOC core particles to characterize whole cells. Previous studies of Thermosynechococcus elongatus found a lower rate of light-saturated O2 from […]
Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Anna Stepanova, Yevgeniya Shurubor, Federica Valsecchi, Giovanni Manfredi, Alexander Galkin Mitochondrial Complex II is a key mitochondrial enzyme connecting the tricarboxylic acid (TCA) cycle and the electron transport chain. Studies of complex II are clinically important since new roles […]
From low- to high-potential bioenergetic chains: Thermodynamic constraints of Q-cycle function
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Lucie Bergdoll, Felix ten Brink, Wolfgang Nitschke, Daniel Picot, Frauke Baymann The electrochemical parameters of all cofactors in the supercomplex formed by the Rieske/cytb complex and the SoxM/A-type O2-reductase from the menaquinone-containing Firmicute Geobacillus stearothermophilus were determined by spectroelectrochemistry […]
The lowest-energy chlorophyll of photosystem II is adjacent to the peripheral antenna: Emitting states of CP47 assigned via circularly polarized luminescence
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Jeremy Hall, Thomas Renger, Frank Müh, Rafael Picorel, Elmars Krausz The identification of low-energy chlorophyll pigments in photosystem II (PSII) is critical to our understanding of the kinetics and mechanism of this important enzyme. We report parallel circular dichroism […]
Tinnitus
P. 093 Pulsatile *tinnitus *due to obstruction of transverse sinus by tentorial meningioma FB Maroun, R Avery, B Lee, P Bartlett, N Hache - Canadian Journal of Neurological …, 2016 Background: The etiology and treatment of pulsatile *tinnitus *is difficult and there are different causes for it. To our knowledge, an obstruction of the transverse sinus due to tentorial meningioma has not been reported. Methods: A 66 year old female presented a year ago *...* Association between the extent of sigmoid sinus dehiscence and an occurrence of pulsatile *tinnitus*: a retrospective imaging s... περισσότερα »
Φαρμακοδυναμικές μελέτες της βορικοναζόλης
: ενημέρωση την κλινική διαχείριση των διηθητικές μυκητιασικές λοιμώξεις KM Ιώβ, Olson J, C Stockmann, JE Κωνσταντίας ... - Expert Επανεξέταση των Αντι ..., 2016 Σελίδα 1. Εκδότης: Taylor & Francis Εφημερίδα: Εξαιρετικός Επανεξέταση των αντιμυκητιασική θεραπεία DOI: 10.1080 / 14787210.2016.1207526 φαρμακοδυναμικές μελέτες της βορικοναζόλης: ενημερώνοντας την κλινική διαχείριση των διηθητικών μυκητιασικών λοιμώξεων *...*
Voice Disorders and Voice Therapy
[PDF] *Voice *symptoms and risk factors for developing *voice *disorders in future musical actors E D'haeseleer, S Claeys, I Meerschman, K Bettens… - … of the Professional *Voice*, 2016 Musical theater students follow an intensive program of singing, acting and physical excercises (dancing) and are expected to participate in long rehearsals and full performances. As they are absolutely depending on their vocal quality and vocal *...* An enterprise opportunity for entrepreneurial students: student enterprise development and experience assessed through the student *voice* R Bell, H B... περισσότερα »
Paroxysmal vertigo with nystagmus in children
Paroxysmal vertigo with nystagmus in children T Okumura, T Imai, K Higashi-Shingai, Y Ohta… - International Journal of …, 2016 *...* Therefore, the diagnosis was right lateral canal type of benign paroxysmal positional vertigo, of which the pathophysiology was *cupulolithiasis*. *...* Fig. 1. Case 1: A 4-year-old female patient with the lateral canal type of BPPV, of which the pathophysiology was *cupulolithiasis*. *...*
Helicobacter pylori infection
[PDF] Autoimmune extraintestinal manifestations of *Helicobacter pylori infection*: A bundle of conflicts E Yula, F Koksal - Journal of Immunology and Clinical Microbiology, 2016 Abstract It has been well-known that several microorganisms that have an effect on particular areas of the body might additionally have systemic sequelae. In the last ten years, various studies have been performed on the relationship between *Helicobacter pylori **...* Systematic review with meta‐analysis: the efficacy of levofloxacin triple therapy as the first‐or second‐line treatments of *Helicobacter pyl... περισσότερα »
Σχέση μεταξύ της οστεοπόρωσης και της οστικής απώλειας σε οριακό οστών αγκυροβολημένο εμφυτεύματα
[PDF] . Αναδρομική μελέτη δύο ετών. Ένα Dominguez, A Μαρία - 2016 Σελίδα 1. Σχέση μεταξύ THESIS ΔΙΔΑΚΤΟΡΙΚΟ οστεοπόρωση και οριακή απώλεια οστού οστεοενσωματούμενα εμφυτεύματα. Δύο - έτος αναδρομική μελέτη Ana Maria Alonso Dominguez Σχολή Οδοντιατρική Πανεπιστήμιο της Σεβίλλης Page 2 διδακτορική διατριβή. *...*
Can tranexamic acid be used to treat upper gastrointestinal bleeds?
Emergency medicine questions: D Hu - The American Journal of Emergency Medicine, 2016 Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. *...* Please enable JavaScript to use all the features on this page. *...* Emergency medicine questions: Can *tranexamic acid* be used to treat upper gastrointestinal bleeds?
Plastic Surgery
Quality Markers in Educational International *Surgical *Experiences and Impact on Future Volunteering. A Schoenbrunner, K Kelley, JK McIntyre, A Gosman - … and *Reconstructive Surgery*– …, 2016 Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. *...* Skip Navigation Links Home > Latest *...* Touch *Surgery *Supporting the *Plastic Surgical *Community. J Nehme, A Chow - *Plastic *and *Rec... περισσότερα »
Regenerative Medicine
[HTML] Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to *Regenerative Medicine* D Srivastava - Etiology and Morphogenesis of Congenital Heart …, 2016 Abstract Heart disease is a leading cause of death in adults and children. We, and others, have described complex signaling, transcriptional, and translational networks that guide early differentiation of cardiac progenitors and later morphogenetic events during *...* [HTML] Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based *regenerative medicine *therapies i... περισσότερα »
Signal transducer and activator of transcription 5A/B
[HTML] Prognostic significance of *signal transducer and activator *of *transcription *5 and 5b expression in Epstein–Barr virus‐positive patients with chronic lymphocytic … PT Diamantopoulos, M Sofotasiou, Z Georgoussi… - Cancer Medicine, 2016 *...* 1999. Stat5a and Stat5b: Fraternal twins of signal transduction and *transcriptional* activation. *...*2008. *Signal* *transducer* *and* *activator* of *transcription* 5A/B in prostate and breast cancers. Endocr. *...*2011. The role of Stat5 *transcription* factors as tumor suppressors or oncogenes. *...*
Fibrous Dysplasia Invading Inferior and Middle Turbinates,Maxillofacial fibrous dysplasia
Nasal Obstruction due to *Fibrous Dysplasia *Invading Inferior and Middle Turbinates: A Case Report and Literature Review HJ Min, YK Park, SK Min, CH Kim - Korean Journal of Otorhinolaryngology-Head and …, 2016 Abstract *Fibrous dysplasia *(FD) is a rare type of fibro-osseous lesion characterized by progressive replacement of normal bone with immature tissue. The involvement of craniofacial bones is reported in 10% of FD cases, while the involvement of sinonasal *...* Maxillofacial *fibrous dysplasia*: a diagnostic challenge. P Markov, AZ Syed, C Markova, RA Mendes - BMJ case reports... περισσότερα »
Internal Auditory Canal Anomalies
: Imaging S Manchanda - Clinico Radiological Series: Temporal Bone Imaging, 2016 *...* Figs 11.14 A and B) • Usually of *vestibular* division and originate near the *vestibular* ganglion • Comet tail or *...* 11.16) –Transmacular—extends into the *vestibule* (Fig. *...* Hearing preservation surgery is not feasible –Extension to the geniculate ganglion—Need for facial *nerve* repair *...*
Fistulas
Laryngeal Framework Surgery in the Irradiated *Neck *A Retrospective Matched Cohort Study M Kubik, C Rosen - Annals of Otology, Rhinology & Laryngology, 2016 *...* All patients had a history of radiation to the anterior *neck*. *...* The procedure was performed *bilaterally* in 50% of cases (14/28). There was no difference between irradiated patients and controls with respect to need for *bilateral* surgery (P = .88). *...* Presentation and Medical Management of Fibrocartilaginous Embolism in the Emergency Department DD Jones, RE Watson, HA Heaton - The Journal of Emergency Medicine,... περισσότερα »
Fibrinolysis
Local *Fibrinolysis *in Spontaneous Supratentorial Hematomas: Comparison with Surgical and Medical Treatment E Condrea, V Timirgaz, S Groppa, I Codreanu… - Interventional Neurology, 2016 Objective: To evaluate the effectiveness of minimally invasive craniopuncture with local *fibrinolysis *in the management of supratentorial spontaneous intracerebral hemorrhage (SICH). Methods: The study included 218 consecutive patients with supratentorial SICH *...* Anaphylactic shock induced hyper-*fibrinolysis*: case report H Koami - Reactions, 2016 The man, with progressive state IV metastatic ... περισσότερα »
Allergens
Sequence conservation predicts T cell reactivity against ragweed *allergens* J Pham, C Oseroff, D Hinz, J Sidney, S Paul… - Clinical & Experimental …, 2016 Background Ragweed is a major cause of seasonal allergy, affecting millions of people worldwide. Several *allergens *have been defined based on IgE reactivity, but their relative immunogenicity in terms of T cell responses has not been studied. Objective We *...* Patterns and risk factors of causative contact *allergens *in Thai adult patients with contact dermatitis at King Chulalongkorn Memorial Hospital. W Dararattanaroj, S Po... περισσότερα »
Photometry
Gaze and discomfort glare, Part 1: Development of a gaze-driven *photometry* MS Khanie, J Stoll, W Einhäuser, J Wienold… - Lighting Research and …, 2016 *...* discomfort glare with certain pupil fluctuations7 and activities of *facial* muscles in *...* HDR*photometry* techniques30 with correct validations31,32 and image processing methods33 have *...* 2.1.1. *Photometric* measurements Luminance measurements were recorded every 30 seconds *...* Model-free non-rigid head pose tracking by joint shape and pose estimation S Cristina, KP Camilleri - Machine Vision and Applications, 2016 *..... περισσότερα »
Endogenous dynorphins
[PDF] Cocaine: Usage, Misuse, and Addiction Processes. An Overview DP Simon, MJ Kreek - 2016 *...* 2012). Indeed, we have shown that the *endogenous* *dynorphin* peptide (*dynorphin* A1–17) is able to stimulate a KOPR-dependent suppression of adenylyl cyclase activity (Claye, Unterwald, Ho, & Kreek, 1996). Sensitization *...* Prodynorphin Epialleles I Bazov, G Bakalkin - Epigenetics and Neuroendocrinology, 2016 *...* Abstract. *Dynorphins*, the *endogenous* ligands for kappa *...* Polymorphisms in the prodynorphin (PDYN), the *dynorphin*-encoding gene, are associated with substance ad... περισσότερα »
The regeneration oftympanic membrane perforations : Hyaluronic acid with or without scaffold material
Effect of hyaluronic acid with or without scaffold material on the regeneration of*tympanic membrane *perforations ZC Lou - European Archives of Oto-Rhino-Laryngology, 2016 *...* In addition, Epifilm may serve as a scaffold, bridging the edges of the perforation, and inducing centripetal epithelial migration, thereby accelerating *eardrum* healing. Epifilm is not superior to other patching materials for regeneration of the *tympanic* *membrane*. *...*
Thyroid Cancer
[PDF] Tumour reduction with a Cavitron Ultrasonic *Surgical *Aspirator® in the palliative care of anaplastic *thyroid cancer* JHR Becker, F Ghoor - South African Journal of *Surgery*, 2016 Abstract A 54-year-old woman developed a fungating locally invasive anaplastic *thyroid * *cancer *with distant metastases, and was treated with aggressive tumour reduction, using a Cavitron® Ultrasonic *Surgical *Aspirator. This mode of treatment, applied for the first time in *...* The Role of SPECT/CT Lymphoscintigraphy and Radioguided Sentinel Lymph Node Biopsy in Managing Papillary *Thyroid C... περισσότερα »
Oral food challenge
[PDF] PEANUTS NA Lee, GC Wright Page 1. PEANUTS BIOACTIVES ALLERGENS Edited by N.Alice Lee, Ph.D. ARC Training Centre for Advanced Technologies in Food Manufacture University of New South Wales Graeme C. Wright, Ph.D. Peanut Company of *...*
Targeting Cancer Stem Cells in Mucoepidermoid Carcinoma
[PDF] A Adams - 2016 *...* intercalated ducts, small excretory ducts, and then through a larger excretory duct that opens into the mouth (6). Excretory ducts are lined with columnar epithelium, cuboidal cells surround the intercalated ducts, and *columnar* *cells* make up the striated duct. As *...*
Pathogenesis of Warthin's tumors
[HTML] YV Kuzenko, AM Romanuk, OO Dyachenko… - Interventional Medicine and …, 2016 *...* In the case of the immunostaining for p63, Dăguci et al. [20] noticed limited nuclear positivity in the basal cells, while the *columnar* *cells*' nucleus were negative. By reverse transcriptase and nested PCR, all tumors expressed p63 [21]. *...*
Pediatric Anesthesia
Principles and Practice of HS Dhayagude, MN Dave - 2016 *...* 1. Anatomy, Growth and Development 3 Bharati Awalegaonkar Kulkarni, Sarita Fernandes � Anthropometry 4 � Face 5 � Teeth 5 � Fontanelles 5 � Neonatal Reflexes 5 � Upper Airway 6 � Lower Airway 8 � Small Airways, Large Controversies 8 � Chest *Wall* 9 � Central *...*
Craniocervical Posture in Patients with Obstructive Sleep Apnea
[HTML] CF Piccin, D Pozzebon, F Scapini, ECR Corrêa - International Archives of …, 2016 *...* We used Statistica version 9.1 *software* for statistical analysis. *...* *pharyngeal* air space; PAS,*Posterior* *pharyngeal* air space; PP2-PP2 ', Average posterolateral *palatal* space; OSAG *...* is, the distance between the *posterior* *pharyngeal* *wall* and the tongue base or *soft* *palate*, and may *...*
Head and Neck Pain
Evaluation of carotid intima-media thickness in children with migraine: a marker of subclinical atherosclerosis HG Poyrazoglu, UE Vurdem, A Arslan, S Uytun - Neurological Sciences, 2016 *...* Future studies evaluating anatomical, hemodynamic, and *functional* aspects will provide more detailed and comprehensive information on this *...* diseases that may occur in patients with migraine by using this simple *imaging* modality, which *...* (2007) Endothelial *function* in patients *...* Acupuncture for the prevention of episodic migraine K Linde, G Allais, B Brinkhaus, Y Fei, M Mehring... περισσότερα »
Long-term observations of radiation-induced creatinine clearance reduction and renal parenchymal volume atrophy
[image: S01678140.gif] Publication date: Available online 29 June 2016 *Source:*Radiotherapy and Oncology Author(s): Koji Inaba, Hiroyuki Okamoto, Akihisa Wakita, Keisuke Tsuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Naoya Murakami, Yoshinori Ito, Hiroshi Igaki, Takashi Uno, Jun Itami PurposeThe kidney is a dose-limiting organ for upper abdominal radiotherapy. In this study, radiation-induced kidney injury represented by changes of creatinine clearance (Ccr) and renal parenchymal volume measured by computed tomo... περισσότερα »
Optimal adaptive IMRT strategy to spare the parotid glands in oropharyngeal cancer
[image: S01678140.gif] Publication date: Available online 29 June 2016 *Source:*Radiotherapy and Oncology Author(s): Pengcheng Zhang, Antoine Simon, Bastien Rigaud, Joël Castelli, Juan David Ospina Arango, Mohamed Nassef, Olivier Henry, Jian Zhu, Pascal Haigron, Baosheng Li, Huazhong Shu, Renaud De Crevoisier PurposeIn oropharyngeal cancer adaptive radiation therapy (ART), this study aimed to quantify the dosimetric benefit of numerous replanning strategies, defined by various numbers and timings of replannings, with regard to parotid gland (PG) sparing.Material and methodsThirteen o... περισσότερα »
Pre-irradiation tumour volumes defined by MRI and dual time-point FET-PET for the prediction of glioblastoma multiforme recurrence: A prospective study
[image: S01678140.gif] Publication date: Available online 1 July 2016 *Source:*Radiotherapy and Oncology Author(s): Maciej Harat, Bogdan Małkowski, Roman Makarewicz Background and purposeThe diagnostic accuracy of magnetic resonance imaging (MRI) for glioblastoma multiforme (GBM) is suboptimal. We analysed pre-treatment MRI- and dual time-point 18F-fluoroethylthyrosine-PET (FET-PET)-based target volumes and GBM recurrence patterns following radiotherapy with temozolomide.Materials and methodsThirty-four patients with primary GBM were treated according to MRI-based treatment volumes ... περισσότερα »
Editorial Board
[image: alertIcon.gif] Publication date: June 2016 *Source:*Radiotherapy and Oncology, Volume 119, Issue 3 from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29dA2ll
A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
Summary Mal de Meleda (MDM) is a palmoplantar keratoderma (PPK), characterized by hyperkeratosis of the palms and soles, and keratotic skin lesions. Patients with MDM can develop perioral erythema, keratotic and lichenoid plaques over the joints (including the elbows and knees), nail abnormalities, joint contractures and stiffness, brachydactyly, sclerodactyly, pseudoainhum, and malodorous maceration. MDM is associated with mutations in the *SLURP1* gene. We report a consanguineous family in which MDM was inherited in an autosomal recessive manner. Genotyping using microsatellite m... περισσότερα »
Dermoscopy and direct immunofluorescence findings of elastosis perforans serpiginosa
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
[image: cover.gif?v=1&s=28a127c82745783ff521bbc0] Summary Elastosis perforans serpiginosa (EPS) is a rare skin disorder characterized by transepidermal elimination of abnormal elastic fibres. We present a new case of D-penicillamine (DPA)-induced EPS, and describe the clinical, dermoscopic, histopathological and direct immunofluorescence (DIF) findings. A 33-year-old woman receiving treatment with DPA presented with annular skin lesions. Digital dermoscopy of the lesions showed a central area of pink and yellowish discolouration with keratotic papules in the periphery, surrounded... περισσότερα »
Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
Objectives/Hypothesis Determine predictive patient characteristics that guide the decision to proceed with surgical management of tongue-based airway obstruction (TBAO) in Pierre Robin sequence (PRS) patients. Study Design Retrospective review of PRS patients between 2005 and 2014 requiring observation in the neonatal intensive care unit (NICU). Methods Patient charts were reviewed for prenatal diagnoses, clinical course, and need for surgical intervention (tracheotomy or mandibular distraction osteogenesis), and the nonsurgical and surgical group were compared with a logistic regr... περισσότερα »
Transoral robotic surgery in the seated position: Rethinking our operative approach
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
Objectives/Hypothesis Transoral surgery (TOS) is commonly performed in a supine patient with an oral retractor. Paradoxically, this strategy can create difficulty with visualizing and accessing pathology at the base of tongue, inferior pharynx, and larynx. We investigate the feasibility of TOS with the patient in the seated position. Study Design Pilot study. Methods TOS utilizing the da Vinci Robotic Surgical Xi and Si systems (Intuitive Surgical, Sunnyvale, CA) was performed on a fresh cadaver placed in both the traditional supine position and the seated position. Transoral robot... περισσότερα »
Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
Objectives/Hypothesis Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three-dimensional configurational changes of the vocal fold medial surface. Study Design In vivo canine hemilarynx model. Methods A hemilaryngectomy was performed in an in vivo canine model and ink was used to mar... περισσότερα »
Low-grade myofibroblastic sarcoma: A population-based study
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics. Study Design Retrospective database analysis. Methods A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between 2001 and 2012. Results There were 49 cases with a 5-year overall survival of 71.6% and disease- specific survival of 76.3%. The ... περισσότερα »
Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To obtain actual status of age-related hearing loss in a general unscreened population of older Dutch adults and to investigate whether the prevalence or degree has changed over time. Study Design To investigate the prevalence and degree of hearing loss, we conducted a large prospective cohort study of older adults between February 2011 and July 2015. Methods Pure-tone air- and bone-conduction thresholds were measured for 4,743 participants. Results were compared to previous cohort studies. Results As expecte... περισσότερα »
An electronic interface to routinize outcomes assessment and streamline clinic workflow
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
http://ift.tt/29mUhRm
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. Study Design Prospective, multicenter, observational cohort. Methods Patients with CRS were enrolled between April 2011 and September 2015. Patients with sinonasal mucocele or unilateral sinus ... περισσότερα »
Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
Objectives/Hypothesis To establish the rate of inflammatory reaction to hyaluronic acid (HA) in vocal fold injection augmentation, determine the most common presenting signs and symptoms, and propose an etiology. Study Design Retrospective chart review. Methods Patients injected with HA over a 5-year period were reviewed to identify those who had a postoperative inflammatory reaction. Medical records were reviewed for patient demographic information, subjective complaints, Voice Handicap Index-10 (VHI-10) scores, medical intervention, and resolution time. Videolaryngostroboscopy ex... περισσότερα »
Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 45 δευτερόλεπτα
Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient’s old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions. http://ift.tt/29iqtHV
Does general anesthesia have a clinical impact on intraocular pressure in children?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Summary Background Reliable measurement of intraocular pressure (IOP) is crucial in pediatric patients with suspected glaucoma. General anesthesia (GA) is usually needed in infants to allow a thorough examination. However, anesthesia itself may influence IOP, depending on the type used and the depth of sedation. The purpose of this study was to evaluate the normal distribution of IOP during GA in healthy children and to analyze differences in IOP relative to the anesthetics used and the measurement time point. Methods Approval for this observational study was received from the lo... περισσότερα »
The splanchnic anti-inflammatory pathway: Could it be the efferent arm of the inflammatory reflex?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Exposure to immune challenges results in the development of inflammation. An insufficient inflammatory response can be life-threatening, whereas an exaggerated response is also detrimental as it causes tissue damage and, in extreme cases, septic shock that can lead to death. Hence, inflammation must be finely regulated. It is generally accepted that the brain inhibits inflammation induced by an immune challenge in two main ways: humorally, by activating the hypothalamic-pituitary-adrenal axis to release glucocorticoids; and neurally, via a mechanism that has been termed the infla... περισσότερα »
Prognostic significance of p53 expression in patients with esophageal cancer: A meta-analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
BMC Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29v3qGA via IFTTT
Ethnic differences in incidence of hepatitis B surface antigen seroclearance in a real-life multicenter clinical cohort of 4737 patients with chronic hepatitis B infection
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Alimentary Pharmacology and Therapeutics from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29t3VDO via IFTTT
Everolimus associated interstitial pneumonitis in a liver transplant patient
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Respiratory Medicine Case Reports from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29v38zz via IFTTT
Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
World Journal of Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29t4ei7 via IFTTT
Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
International Journal of Obesity from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29v3rKM via IFTTT
The efficacy of levofloxacin triple therapy as the first- or second-line treatments of Helicobacter pylori infection
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Alimentary Pharmacology and Therapeutics from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29t3WYB via IFTTT
Prognosis of patients with esophageal squamous cell carcinoma who achieve major histopathological response after neoadjuvant chemoradiotherapy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
European Journal of Surgical Oncology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29lQKBx via IFTTT
Isolated hepatitis B core antibody status is not associated with accelerated liver disease progression in HIV/hepatitis C coinfection
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Journal of Acquired Immune Deficiency Syndromes from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sHoGY via IFTTT
Laparoscopic-assisted pull-through operation for Hirschsprung's disease: A systematic review and meta-analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Pediatric Surgery International from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29lQXo5 via IFTTT
Comparison of daily versus weekly recording of gastroesophageal reflux disease symptoms in patients with a partial response to proton pump inhibitor therapy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Value in Health from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sHhLn via IFTTT
A SMAD4 mutation indicative of juvenile polyposis syndrome in a family previously diagnosed with Menetrier's disease
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Digestive and Liver Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29lQToA via IFTTT
Prevalence and clinical significance of IgA anti tissue transglutaminase antibodies in patients with chronic liver disease
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Journal of Gastroenterology and Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sH7DO via IFTTT
Paradoxical articular manifestations in patients with inflammatory bowel diseases treated with infliximab
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
European Journal of Gastroenterology & Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29lR6bo via IFTTT
Low testosterone in non-responsive coeliac disease: A case series, case-control study with comparisons to the National Health and Nutrition Examination Survey
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 46 δευτερόλεπτα
Digestive and Liver Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sH9M7 via IFTTT
PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
Abstract Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy (TSE) has been described following inoculation and passage of various forms of fibrils in transgenic mice and hamsters. However, in studies described here, we show that inoculat... περισσότερα »
The splanchnic anti-inflammatory pathway: Could it be the efferent arm of the inflammatory reflex?
Exposure to immune challenges results in the development of inflammation. An insufficient inflammatory response can be life-threatening, whereas an exaggerated response is also detrimental as it causes tissue damage and, in extreme cases, septic shock that can lead to death. Hence, inflammation must be finely regulated. It is generally accepted that the brain inhibits inflammation induced by an immune challenge in two main ways: humorally, by activating the hypothalamic-pituitary-adrenal axis to release glucocorticoids; and neurally, via a mechanism that has been termed the inflam... περισσότερα »
Startle amplitude during unpleasant pictures is greater in veterans with a history of multiple-suicide attempts and predicts a future suicide attempt
Abstract Recent studies demonstrate that veterans exhibit higher suicide risk compared with the general U.S. population. A prior suicide attempt is a well-documented predictor of suicide death. Despite increased attention to clinical risk factors of suicide and efforts to develop psychosocial interventions to reduce suicide risk, the underlying biological factors that confer this risk are not well understood. This study examined affect-modulated startle (AMS) during a series of intermixed unpleasant, neutral, and pleasant pictures in a sample of 108 demographically-matched veterans... περισσότερα »
PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
Abstract Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy… Continue reading PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
Objectives/Hypothesis Determine predictive patient characteristics that guide the decision to proceed with surgical management of tongue-based airway obstruction (TBAO) in Pierre Robin sequence (PRS) patients. Study Design Retrospective review of PRS patients between 2005 and 2014 requiring observation in the neonatal intensive care unit (NICU). Methods Patient charts were reviewed for prenatal diagnoses, clinical course,… Continue reading Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
Objectives/Hypothesis Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three-dimensional… Continue reading Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
Transoral robotic surgery in the seated position: Rethinking our operative approach
Objectives/Hypothesis Transoral surgery (TOS) is commonly performed in a supine patient with an oral retractor. Paradoxically, this strategy can create difficulty with visualizing and accessing pathology at the base of tongue, inferior pharynx, and larynx. We investigate the feasibility of TOS with the patient in the seated position. Study Design Pilot study. Methods TOS utilizing… Continue reading Transoral robotic surgery in the seated position: Rethinking our operative approach
Low-grade myofibroblastic sarcoma: A population-based study
Objectives/Hypothesis Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics. Study Design Retrospective database analysis. Methods A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between… Continue reading Low-grade myofibroblastic sarcoma: A population-based study
Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
Objectives/Hypothesis To obtain actual status of age-related hearing loss in a general unscreened population of older Dutch adults and to investigate whether the prevalence or degree has changed over time. Study Design To investigate the prevalence and degree of hearing loss, we conducted a large prospective cohort study of older adults between February 2011 and… Continue reading Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation
Objectives/Hypothesis To establish the rate of inflammatory reaction to hyaluronic acid (HA) in vocal fold injection augmentation, determine the most common presenting signs and symptoms, and propose an etiology. Study Design Retrospective chart review. Methods Patients injected with HA over a 5-year period were reviewed to identify those who had a postoperative inflammatory reaction. Medical… Continue reading Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation
An electronic interface to routinize outcomes assessment and streamline clinic workflow
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29mUhRm via IFTTT
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. Study Design Prospective, multicenter, observational cohort. Methods… Continue reading Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
Single-walled carbon nanotubes covalently functionalized with polytyrosine: A new material for the development of NADH-based biosensors
Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Marcos Eguílaz, Fabiana Gutierrez, Jose Miguel González-Domínguez, María T. Martínez, Gustavo Rivas We report for the first time the use of single-walled carbon nanotubes (SWCNT) covalently functionalized with polytyrosine (Polytyr) (SWCNT-Polytyr) as a new electrode material for the development of nicotinamide adenine dinucleotide (NADH)-based biosensors. The oxidation of glassy carbon electrodes (GCE) modified with SWCNT-Polytyr at potentials high enough to oxidize the tyrosine residues... περισσότερα »
FOXN1 in thymus organogenesis and development
Development of the primary T-cell repertoire takes place in the thymus. The linked processes of T-cell differentiation and T-cell repertoire selection each depend on interactions between thymocytes and thymic stromal cells; in particular, with the epithelial cells of the cortical and medullary thymic compartments (cortical and medullary thymic epithelial cells; cTECs and mTECs, respectively). The importance of the thymic epithelial cell lineage in these processes was revealed in part through analysis of *nude* (*nu/nu*) mice, which are congenitally hairless and athymic. The *nude*... περισσότερα »
IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation
[image: cover.gif?v=1&s=7ed1ee29e575b52989bb5c85] The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signals that differentially influence their effector characteristics are poorly characterized. In this study, we defined the phenotype of discrete subsets of effective antigen-presenting cells (APCs) in the peritoneal cavity during peritoniti... περισσότερα »
Does general anesthesia have a clinical impact on intraocular pressure in children?
Summary Background Reliable measurement of intraocular pressure (IOP) is crucial in pediatric patients with suspected glaucoma. General anesthesia (GA) is usually needed in infants to allow a thorough examination. However, anesthesia itself may influence IOP, depending on the type used and the depth of sedation. The purpose of this study was to evaluate the normal distribution of IOP during GA in healthy children and to analyze differences in IOP relative to the anesthetics used and the measurement time point. Methods Approval for this observational study was received from the lo... περισσότερα »
Logistic regression analysis of Pierre Robin sequence patients requiring surgical intervention
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis Determine predictive patient characteristics that guide the decision to proceed with surgical management of tongue-based airway obstruction (TBAO) in Pierre Robin sequence (PRS) patients. Study Design Retrospective review of PRS patients between 2005 and 2014 requiring observation in the neonatal intensive care unit (NICU). Methods Patient charts were reviewed for prenatal diagnoses, clinical course, […]
Three-dimensional posture changes of the vocal fold from paired intrinsic laryngeal muscles
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis Although the geometry of the vocal fold medial surface affects voice quality and is critical in the treatment of glottic insufficiency, the prephonatory shape of the vocal fold medial surface is not well understood. In this study, we activated intrinsic laryngeal muscles individually and in combinations, and recorded the temporal sequence and precise three-dimensional […]
Transoral robotic surgery in the seated position: Rethinking our operative approach
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis Transoral surgery (TOS) is commonly performed in a supine patient with an oral retractor. Paradoxically, this strategy can create difficulty with visualizing and accessing pathology at the base of tongue, inferior pharynx, and larynx. We investigate the feasibility of TOS with the patient in the seated position. Study Design Pilot study. Methods TOS utilizing […]
Low-grade myofibroblastic sarcoma: A population-based study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics. Study Design Retrospective database analysis. Methods A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between […]
Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis To obtain actual status of age-related hearing loss in a general unscreened population of older Dutch adults and to investigate whether the prevalence or degree has changed over time. Study Design To investigate the prevalence and degree of hearing loss, we conducted a large prospective cohort study of older adults between February 2011 and […]
Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis To establish the rate of inflammatory reaction to hyaluronic acid (HA) in vocal fold injection augmentation, determine the most common presenting signs and symptoms, and propose an etiology. Study Design Retrospective chart review. Methods Patients injected with HA over a 5-year period were reviewed to identify those who had a postoperative inflammatory reaction. Medical […]
An electronic interface to routinize outcomes assessment and streamline clinic workflow
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29mUhRm via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. Study Design Prospective, multicenter, observational cohort. Methods […]
The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis – a pilot study using a Syrian hamster model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective Oral mucositis (OM) is a common complication of chemotherapy and radiotherapy. The aim of this study was to evaluate the effects of treating 5-fluorouracil-induced OM with apigenin and dexamethasone. Methods Thirty-six male Syrian hamsters were randomly assigned to one of three groups: control (50% acetic acid + 5-FU), 50% acetic acid + 5-FU + […]
Crossmodal plasticity in auditory, visual and multisensory cortical areas following noise-induced hearing loss in adulthood
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 4 July 2016 Source:Hearing Research Author(s): Ashley L. Schormans, Marei Typlt, Brian L. Allman Complete or partial hearing loss results in an increased responsiveness of neurons in the core auditory cortex of numerous species to visual and/or tactile stimuli (i.e., crossmodal plasticity). At present, however, it remains uncertain how adult-onset partial […]
Alterations of p14 ARF , p15 INK4b , and p16 INK4a Genes in Primary Laryngeal Squamous Cell Carcinoma
Abstract The 9p21 gene cluster, harboring growth suppressive genes *p14* *ARF* , *p15* *INK4b* , and *p16* *INK4a* , is one of the major aberration hotspots in head and neck cancers. We try to elucidate specific aberrations affecting this region, throughout methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay. Methylation of the gene was investigated by MS-MLPA in a well-characterized series of 27 laryngeal squamous cell carcinomas and 20 samples of healthy mucosa. Aberrant promoter hypermethylation was confirmed using and methylation-specific. All... περισσότερα »
Migration of nonylphenol and plasticizers from polyvinyl chloride stretch film into food simulants, rapeseed oil, and foods
Abstract Nonylphenol (NP) has been suspected as an endocrine-disrupting chemical. Japanese polyvinyl chloride (PVC) stretch films contained 0.5–3.3 mg/g of NP and 100–400 mg/g of plasticizers such as diisononyl adipate (DINA), di- *n*-alkyl adipate (DAA), and diacetyllauroyl glycerol (DALG). Migration of NP and plasticizers from PVC stretch films into food simulants (water; 4% acetic acid; 20%, 50%, and 95% ethanol; and heptane), rapeseed oil, and foods was investigated. Plasticizers migrated only in small amounts into aqueous simulants and foods, although they migrated at much highe... περισσότερα »
Nutrient content of fish powder from low value fish and fish byproducts
Abstract Consuming small-sized fish species whole, and bones of large fish could contribute significantly to reducing the level of micronutrient and protein malnutrition. These fish products are more affordable and could therefore meet the needs of poor, vulnerable groups, particularly in rural and urban areas where limited economic resources prevent dietary diversity. The objectives of the study were to produce fish powder from dried edible byproducts from fish processing factories, an underutilized fish species, burrito and to determine the physical, micromineral, macronutrient an... περισσότερα »
Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats
Abstract Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects. In addition, melatonin has received special attention in pain treatment since it is effective and presents few adverse effects. In this study, we evaluated the effect of acute dose of melatonin upon hyperalgesia induced by complete Freund’s adjuvant in a chronic orofacial pain model in Sprague–Dawley rats. Nociceptive behavior was assessed by facial Von Frey and t... περισσότερα »
Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway
Abstract Previous studies have demonstrated that hesperidin, a flavanone glycoside from citrus fruits, produces antidepressant-like effects in both mice and rats. However, whether these effects are mediated by pro-inflammatory cytokines remains unknown. In the present study, we attempted to investigate the effects of hesperidin on the depressive-like behavior; the serum corticosterone concentrations; and the interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNF-α) levels in lipopolysaccharide (LPS)-induced depression-like mice. In particular, we evaluated the miRNA-132 ex... περισσότερα »
Effects of Theophylline with Methylprednisolone Combination Therapy on Biomechanics and Histopathology in Diaphragm Muscles of Rats
Abstract The purpose of this study was to investigate the effects of theophylline and methylprednisolone on the mechanical response and histopathology of hemidiaphragm muscle in rats. In the current study, we aimed to investigate the effects of theophylline and methylprednisolone, which are frequently used in clinics and which have different effects on the respiratory system and on the biomechanics and histopathology of the diaphragm muscle. The study included four groups of rats. Group T received 1 mg/kg of intraperitoneal theophylline, group M received 2 mg/kg of intraperitoneal ... περισσότερα »
EBUS-TBNA of Pulmonary Artery Clot
[image: image]No abstract available from Respiratory via xlomafota13 on Inoreader http://ift.tt/29iic6z
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