The surgical management of cephalalgia
Purpose of review: Management of headache disorders is not part of most craniomaxillofacial surgery practices; however there are certain indications for surgical management of headaches by the craniomaxillofacial surgeon. Recent findings: Migraine headaches are the most amenable to surgical management and while the exact mechanism of migraine is unknown, a central or peripheral trigger such… Continue reading The surgical management of cephalalgia
Update in alar base reduction in rhinoplasty
Purpose of review: The purpose of this article is to further explore the techniques available for alar base reduction by a recent review in this topic, focusing in the current advances in the field, in a clear and readable format. Recent findings: Among the numerous techniques available, the management of cases with wide nasal base… Continue reading Update in alar base reduction in rhinoplasty
Simulation in craniomaxillofacial training
Purpose of review: Simulation in healthcare is no longer a novel idea. Simulation continues to rapidly permeate and transform both clinical practice and medical education. Craniomaxillofacial surgery is comprised of multiple surgical disciplines, including neurosurgery, plastic surgery, otolaryngology, ophthalmology, and oral and maxillofacial surgery. All of these specialties are performing surgery in an era of… Continue reading Simulation in craniomaxillofacial training
Hermann Oppenheim. Anmerkungen zu seinem Leben und Wirken
Zusammenfassung Der herausragende Nervenarzt Hermann Oppenheim war bereits zu seiner Zeit weltweit bekannt und wurde hoch geschätzt. Aber er war auch eine widersprüchliche, vielschichtige Persönlichkeit und sein Leben wurde von mehreren tragischen Ereignissen geprägt. Bereits für seine Zeitgenossen war sein Leben und Wirken Gegenstand lebhafter Diskussionen und Auseinandersetzungen. Und auch noch rund 100 Jahre später… Continue reading Hermann Oppenheim. Anmerkungen zu seinem Leben und Wirken
Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option
Introduction: The prognostic outcome following progression after palliative first-line treatment for patients suffering from metastatic colorectal adenocarcinoma is generally poor. Long-term relapse-free survival with palliative second-line treatment may be achieved in only a limited number of individual cases. Case Report: A 37-year-old patient presented with bilobar liver metastases of colon cancer confirmed by histology with… Continue reading Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Co... περισσότερα »
Electrosprayed Montelukast/Poly (Lactic-co-Glycolic Acid) Particle based Coating: a New Therapeutic Approach towards the Prevention of In-stent Restenosis
Publication date: Available online 7 July 2016 Source:Acta Biomaterialia Author(s): Maedeh Zamani, Molamma P. Prabhakaran, Jaleh Varshosaz, Priyadarshini S. Mhaisalkar, Seeram Ramakrishna Drug-eluting stents (DESs), have shown promising results in prevention of in-stent restenosis after percutaneous coronary intervention (PCI). The elevated level of leukotrienes (LTs) detected in injured arteries after PCI, together with the potential… Continue reading Electrosprayed Montelukast/Poly (Lactic-co-Glycolic Acid) Particle based Coating: a New Therapeutic Approach towards the Prevention ... περισσότερα »
Corrosion-Wear of β-Ti Alloy TMZF (Ti-12Mo-6Zr-2Fe) in Simulated Body Fluid
Publication date: Available online 7 July 2016 Source:Acta Biomaterialia Author(s): Xueyuan Yang, Christopher Hutchinson Titanium alloys are popular metallic implant materials for use in total hip replacements. Although, α+β titanium alloys such as Ti-6Al-4V have been the most commonly used alloys, the high Young’s modulus (∼110 GPa) leads to an undesirable stress shielding effect. An… Continue reading Corrosion-Wear of β-Ti Alloy TMZF (Ti-12Mo-6Zr-2Fe) in Simulated Body Fluid
Characteristics of Thoracic Aortic Aneurysm Rupture in vitro
Publication date: Available online 6 July 2016 Source:Acta Biomaterialia Author(s): Yuanming Luo, Ambroise Duprey, Stéphane Avril, Jia Lu Ascending thoracic aortic aneurysms (ATAAs) are focal dilatations in the aorta that are prone to rupture or dissection. To accurately evaluate the rupture risk, one must know the local mechanical conditions at the rupture site and understand… Continue reading Characteristics of Thoracic Aortic Aneurysm Rupture in vitro
Engineering of Caveolae-specific Self-micellizing Anticancer Lipid Nanoparticles to Enhance the Chemotherapeutic Efficacy of Oxaliplatin in Colorectal Cancer Cells
Publication date: Available online 6 July 2016 Source:Acta Biomaterialia Author(s): Pasupathi Sundaramoorthy, Thiruganesh Ramasamy, Siddhartha Kumar Mishra, Keun-Yeong Jeong, Chul Soon Yong, Jong Oh Kim, Hwan Mook Kim Novel nanomaterials for the intracellular transport of therapeutic cargos have been actively sought to effectively breach cell-membrane barriers. In this study we developed novel self-micellizing anticancer lipid… Continue reading Engineering of Caveolae-specific Self-micellizing Anticancer Lipid Nanoparticles to Enhance the Chemotherapeutic Efficacy of Oxaliplatin in ... περισσότερα »
Macrophage reaction against biomaterials in the mouse model – phenotypes, functions and markers
Publication date: Available online 6 July 2016 Source:Acta Biomaterialia Author(s): R. Klopfleisch The foreign body reaction (FBR) is a response of the host tissue against more or less degradation-resistant foreign macromolecular material. The reaction is divided into five different phases which involve most aspects of the innate and the adaptive immune system: protein adsorption, acute… Continue reading Macrophage reaction against biomaterials in the mouse model – phenotypes, functions and markers
Anxiety and depression, personality traits relevant to tinnitus: A scoping review
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
10.1080/14992027.2016.1198966<br>Mithila Durai http://ift.tt/29s3KpX
Comment on ‘The effects of frequency lowering on speech perception in noise with adult hearing-aid users’
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
10.1080/14992027.2016.1200753<br>Jason A. Galster http://ift.tt/29mbrje
A Novel Frameshift Mutation of SLC26A4 in a Korean Family With Nonsyndromic Hearing Loss and Enlarged Vestibular Aqueduct.
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
*A Novel Frameshift Mutation of SLC26A4 in a Korean Family With Nonsyndromic Hearing Loss and Enlarged Vestibular Aqueduct.* Clin Exp Otorhinolaryngol. 2016 Jul 7; Authors: Sagong B, Baek JI, Lee KY, Kim UK Abstract Objectives: We aimed to identify the causative mutation for siblings in a Korean family with nonsyndromic hearing loss (HL) and enlarged vestibular aqueduct (EVA). The siblings were a 19-year-old female with bilateral profound HL and an 11-year-old male with bilateral moderately severe HL. Methods: We extracted genomic DNA from blood samples of the siblings with HL, th... περισσότερα »
SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans.
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
*SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans.* J Hum Genet. 2016 Jul 7; Authors: Guan J, Wang D, Cao W, Zhao Y, Du R, Yuan H, Liu Q, Lan L, Zong L, Yang J, Yin Z, Han B, Zhang F, Wang Q Abstract The ossicles represent one of the most fundamental morphological features in evolutionary biology of the mammalians. The mobile ossicular morphology abnormalities result in the severe conductive hearing loss. Development and patterning of the middle ear malformation depend on genetic and environmental causes. However, the genetic basis for the risk of cong... περισσότερα »
Update on reconstructive options for nasal Mohs defects 1.5 cm or less
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Purpose of review: The article reviews the current literature to provide an overview on contemporary reconstructive options for closure of Mohs defects of the nose that are 1.5 cm or less. Recent findings: Although some of the techniques described in the literature are of historical importance only, others have undergone modification and metamorphosis to be broadly […]
Recent trends in the treatment of benign odontogenic tumors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Purpose of review: The management of benign, locally aggressive odontogenic tumors, namely, keratocystic odontogenic tumors (KOTs) and ameloblastomas, can be challenging. The purpose of this article is to briefly summarize important features of these lesions and review recent trends in the literature regarding their treatment. Recent findings: Currently, KOTs are frequently treated with a conservative […]
Current updates in nasal bone reshaping
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Purpose of review: To review recent studies on nasal osseocartilaginous anatomy, osteotomy techniques and contemporary methods of nasal bone reshaping carried out under direct vision. Recent findings: Current cadaver studies on osseocartilaginous vault anatomy, osteotomy techniques provide valuable information that can reduce outcome variability and increase reliability of osteotomies. Nevertheless, osteotomes have limitations and contemporary […]
The surgical management of cephalalgia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Purpose of review: Management of headache disorders is not part of most craniomaxillofacial surgery practices; however there are certain indications for surgical management of headaches by the craniomaxillofacial surgeon. Recent findings: Migraine headaches are the most amenable to surgical management and while the exact mechanism of migraine is unknown, a central or peripheral trigger such […]
Update in alar base reduction in rhinoplasty
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Purpose of review: The purpose of this article is to further explore the techniques available for alar base reduction by a recent review in this topic, focusing in the current advances in the field, in a clear and readable format. Recent findings: Among the numerous techniques available, the management of cases with wide nasal base […]
Simulation in craniomaxillofacial training
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Purpose of review: Simulation in healthcare is no longer a novel idea. Simulation continues to rapidly permeate and transform both clinical practice and medical education. Craniomaxillofacial surgery is comprised of multiple surgical disciplines, including neurosurgery, plastic surgery, otolaryngology, ophthalmology, and oral and maxillofacial surgery. All of these specialties are performing surgery in an era of […]
Hermann Oppenheim. Anmerkungen zu seinem Leben und Wirken
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Zusammenfassung Der herausragende Nervenarzt Hermann Oppenheim war bereits zu seiner Zeit weltweit bekannt und wurde hoch geschätzt. Aber er war auch eine widersprüchliche, vielschichtige Persönlichkeit und sein Leben wurde von mehreren tragischen Ereignissen geprägt. Bereits für seine Zeitgenossen war sein Leben und Wirken Gegenstand lebhafter Diskussionen und Auseinandersetzungen. Und auch noch rund 100 Jahre später […]
Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction: The prognostic outcome following progression after palliative first-line treatment for patients suffering from metastatic colorectal adenocarcinoma is generally poor. Long-term relapse-free survival with palliative second-line treatment may be achieved in only a limited number of individual cases. Case Report: A 37-year-old patient presented with bilobar liver metastases of colon cancer confirmed by histology with […]
Quantitative Analysis of Change in Intracranial Volume After Posterior Cranial Vault Distraction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Quantitative Analysis of Change in Intracranial Volume After Posterior Cranial Vault Distraction: Abstract: Posterior cranial vault distraction is considered to be more effective for increasing intracranial volume than fronto-orbital advancement or anterior cranial vault expansion, but the changes in intracranial volumes after posterior cranial vault distraction remain unclear. The changes in intracranial volume were investigated […]
Treatment of Symptomatic Osteoma on Eyebrow Using Adjacent Supraorbital Neuroperiosteal Flap
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Treatment of Symptomatic Osteoma on Eyebrow Using Adjacent Supraorbital Neuroperiosteal Flap: Abstract: Osteomas grow slowly, blocking or compressing adjacent structures, and frequently causing aesthetic deformity. Although most patients remain asymptomatic, development of facial pain and headaches due to compression of adjacent sensory nerves is not uncommon. Depending on the location of osteoma, many techniques were […]
Apert Syndrome: Outcomes From the Australian Craniofacial Unit’s Birth to Maturity Management Protocol
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Apert Syndrome: Outcomes From the Australian Craniofacial Unit’s Birth to Maturity Management Protocol: Abstract: The complex, progressive, multisystem nature of Apert syndrome presents many challenges to managing surgeons. Based on the pioneering work of Paul Tessier, the senior author developed a multidisciplinary birth to maturity management protocol for Apert syndrome. Between 1975 and 2014 the […]
The Importance of Esophagography in Patients With Recessive Dystrophic Epidermolysis Bullosa.
*The Importance of Esophagography in Patients With Recessive Dystrophic Epidermolysis Bullosa.* AJR Am J Roentgenol. 2016 Jul 6;:1-4 Authors: Guerra-Leal JD, Meester I, Cantu-Gonzalez JR, Ornelas-Cortinas G, Montemayor-Martinez A, Salas-Alanis JC Abstract OBJECTIVE: The purpose of this study was to assess esophageal damage in patients with recessive dystrophic epidermolysis bullosa (RDEB) with or without dysphagia. SUBJECTS AND METHODS: Fourteen patients with either severe generalized or another generalized form of RDEB recruited through a research and support foundation were eva... περισσότερα »
An Epidemiologic Study on Ageing and Dysphagia in the Acute Care Geriatric-Hospitalized Population: A Replication and Continuation Study.
*An Epidemiologic Study on Ageing and Dysphagia in the Acute Care Geriatric-Hospitalized Population: A Replication and Continuation Study.* Dysphagia. 2016 Jul 6; Authors: Leder SB, Suiter DM, Agogo GO, Cooney LM Abstract United States census data project dramatic increases in the geriatric population ageing demographics by 2060 with concomitant health-care consequences. The purpose of this replication and continuation study was to collect new 2014 demographic data relative to ageing, swallow evaluation referral rates, and oral feeding status in geriatric-hospitalized patients fo... περισσότερα »
Outcome of Rehabilitation and Swallowing Therapy After Percutaneous Endoscopic Gastrostomy in Dysphagia Patients.
*Outcome of Rehabilitation and Swallowing Therapy After Percutaneous Endoscopic Gastrostomy in Dysphagia Patients.* Dysphagia. 2016 Jul 6; Authors: Toh Yoon EW, Hirao J, Minoda N Abstract The objective of this study was to investigate the outcomes of rehabilitation (with swallowing therapy) after percutaneous endoscopic gastrostomy (PEG) in patients with neurogenic dysphagia. Forty-seven patients (29 males and 18 females) who were transferred to the rehabilitation ward of our hospital after receiving PEG tube placements during a 5-year period were enrolled in this study. Patients... περισσότερα »
Diffusion-weighted-preparation (D-prep) MRI as a future extension of SPECT/CT based surgical planning for sentinel node procedures in the head and neck area?
Publication date: September 2016 *Source:*Oral Oncology, Volume 60 Author(s): Tessa Buckle, Gijs H. KleinJan, Thijs Engelen, Nynke S. van den Berg, Marco C. DeRuiter, Uulke van der Heide, Renato A. Valdes Olmos, Andrew Webb, Mark A. van Buchem, Alfons J. Balm, Fijs W.B. van Leeuwen PurposeEven when guided by SPECT/CT planning of nodal resection in the head-and-neck area is challenging due to the many critical anatomical structures present within the surgical field. In this study the potential of a (SPECT/)MRI-based surgical planning method was explored. Hereby MRI increases the iden... περισσότερα »
Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma
Publication date: September 2016 *Source:*Oral Oncology, Volume 60 Author(s): William G. Albergotti, Kara S. Davis, Shira Abberbock, Julie E. Bauman, James Ohr, David A. Clump, Dwight E. Heron, Umamaheswar Duvvuri, Seungwon Kim, Jonas T. Johnson, Robert L. Ferris BackgroundPretreatment body mass index (BMI) >25kg/m2 is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in ... περισσότερα »
Construction of Hindi Speech Stimuli for Eliciting Auditory Brainstem Responses
Abstract Speech-evoked auditory brainstem responses (spABRs) provide considerable information of clinical relevance to describe auditory processing of complex stimuli at the sub cortical level. The substantial research data have suggested faithful representation of temporal and spectral characteristics of speech sounds. However, the spABR are known to be affected by acoustic properties of speech, language experiences and training. Hence, there exists indecisive literature with regards to brainstem speech processing. This warrants establishment of language specific speech stimulus ... περισσότερα »
Effects of four-month handbike training under free-living conditions on physical fitness and health in wheelchair users.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Effects of four-month handbike training under free-living conditions on physical fitness and health in wheelchair users.* Disabil Rehabil. 2016 Jul 6;:1-8 Authors: Hoekstra S, Valent L, Gobets D, van der Woude L, de Groot S Abstract PURPOSE: Recognizing the encouraging effect of challenging events, the HandbikeBattle (HBB) was created to promote exercise among wheelchair users. The purpose of this study was to reveal the effects on physical fitness and health outcomes of four-month handbike training under free-living conditions in preparation for the event. METHODS: In this prosp... περισσότερα »
Reliability and validity of the Finnish version of the Lower Extremity Functional Scale (LEFS).
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Reliability and validity of the Finnish version of the Lower Extremity Functional Scale (LEFS).* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Repo JP, Tukiainen EJ, Roine RP, Ilves O, Järvenpää S, Häkkinen A Abstract PURPOSE: The present study aimed to assess the psychometric properties of the Finnish version of the Lower Extremity Functional Scale (LEFS) among foot and ankle patients. METHODS: The LEFS was translated and cross-culturally adapted to Finnish. We assessed the test-retest reliability, internal consistency, floor-ceiling effect, construct validity and criterion validity... περισσότερα »
Long-term impact of stroke on patients' health-related quality of life.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Long-term impact of stroke on patients' health-related quality of life.* Disabil Rehabil. 2016 Jul 6;:1-6 Authors: De Wit L, Theuns P, Dejaeger E, Devos S, Gantenbein AR, Kerckhofs E, Schuback B, Schupp W, Putman K Abstract PURPOSE: This international study aims to examine the size and determinants of the impact of stroke on five-year survivors' health-related quality of life (HRQoL) in four different European countries. METHOD: Patients were recruited consecutively in four European rehabilitation centers. Five years after stroke, the EuroQol-visual analog scale (EQ-VAS) was admi... περισσότερα »
Embedding technology into inter-professional best practices in home safety evaluation.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Embedding technology into inter-professional best practices in home safety evaluation.* Disabil Rehabil Assist Technol. 2016 Jul 6;:1-7 Authors: Burns SP, Pickens ND Abstract PURPOSE: To explore inter-professional home evaluators' perspectives and needs for building useful and acceptable decision-support tools for the field of home modifications. METHOD: Twenty semi-structured interviews were conducted with a range of home modification professionals from different regions of the United States. The interview transcripts were analyzed with a qualitative, descriptive, perspective a... περισσότερα »
Referral decision support in patients with subacute brain injury: evaluation of the Rehabilitation Complexity Scale - Extended.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Referral decision support in patients with subacute brain injury: evaluation of the Rehabilitation Complexity Scale - Extended.* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Pedersen AR, Nielsen JF, Jensen J, Maribo T Abstract PURPOSE: To test if the Rehabilitation Complexity Scale Extended (RCS-E) can be used as decision support for patient referral to primary rehabilitation as either complex specialized services (CSS) or district specialist services (DSS). METHOD: Two independent expert teams analyzed medical records on 299 consecutive patients admitted for CSS or DSS rehabilitati... περισσότερα »
Targeting Cancer Stem-like Cells in Glioblastoma and Colorectal Cancer through Metabolic Pathways
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
Targeting Cancer Stem-like Cells in Glioblastoma and Colorectal Cancer through Metabolic Pathways: Abstract Cancer stem-like cells (CSCs) are thought to be the main cause of tumor occurrence, progression and therapeutic resistance. Strong research efforts in the last decade have led to the development of several tailored approaches to target CSCs with some very promising clinical trials underway, however, until now no anti-CSC therapy has been approved for clinical use. Given the recent improvement in our understanding of how onco-proteins can manipulate cellular metabolic network... περισσότερα »
Mammographic density is the main correlate of tumors detected on ultrasound, but not on mammography
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
Mammographic density is the main correlate of tumors detected on ultrasound, but not on mammography: Abstract Although mammography screening programs do not include ultrasound examinations, some diagnostic units do provide women with both mammography and ultrasonography. This article is concerned with estimating the risk of a breast cancer patient diagnosed in a hospital-based mammography unit having a tumor that is visible on ultrasound but not on mammography. A total of 1399 women with invasive breast cancer from a hospital-based diagnostic mammography unit were included in this... περισσότερα »
Dosing Targeted and Cytotoxic Two-Drug Combinations: Lessons Learned from Analysis of 24,326 Patients Reported 2010 through 2013
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
Dosing Targeted and Cytotoxic Two-Drug Combinations: Lessons Learned from Analysis of 24,326 Patients Reported 2010 through 2013: ABSTRACT Combining agents has the potential to attenuate resistance in metastatic cancer. However, knowledge of appropriate starting doses for novel drug combinations in clinical trials and practice is lacking. Analysis of 372 published studies was used to ascertain safe starting doses for doublets involving a cytotoxic and targeted agent. Phase I-III adult oncology clinical trial publications (January 1, 2010 to December 31, 2013) were identified (PubM... περισσότερα »
Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in Human Hacat keratinocytes
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in Human Hacat keratinocytes: Abstract Among food contaminants, mycotoxins are toxic to both human and animal health. Our prior studies suggest that Deoxynivalenol (DON), a mycotoxin, behaves as a tumor promoter by inducing edema, hyperplasia, ODC activity and activation of MAPK's in mouse skin. In the present study topical application of DON, 336 and 672 nmol significantly enhanced ROS levels, DNA damage and apoptosis with concomitant downregulation of Ki-67, cyclin D, cyclin E, cyclin A and c... περισσότερα »
Ferumoxytol-enhanced MRI differentiation of meningioma from dural metastases: a pilot study with immunohistochemical observations
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
Ferumoxytol-enhanced MRI differentiation of meningioma from dural metastases: a pilot study with immunohistochemical observations: Abstract Malignant dural neoplasms are not reliably distinguished from benign dural neoplasms with contrast-enhanced magnetic resonance imaging (MRI). MRI enhancement in central nervous system (CNS) diseases imaged with ferumoxytol has been attributed to intracellular uptake in macrophages rather than vascular leakage. We compared imaging to histopathology and immunohistochemistry in meningiomas and dural metastases having ferumoxytol-enhanced MRI (FeM... περισσότερα »
Integrative analysis of diffusion-weighted MRI and genomic data to inform treatment of glioblastoma
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
Integrative analysis of diffusion-weighted MRI and genomic data to inform treatment of glioblastoma: Abstract Gene expression profiling from glioblastoma (GBM) patients enables characterization of cancer into subtypes that can be predictive of response to therapy. An integrative analysis of imaging and gene expression data can potentially be used to obtain novel biomarkers that are closely associated with the genetic subtype and gene signatures and thus provide a noninvasive approach to stratify GBM patients. In this retrospective study, we analyzed the expression of 12,042 genes ... περισσότερα »
Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus.* Radiology. 2016 Jul 7;:151951 Authors: Fraga de Abreu VH, Peck KK, Petrovich-Brennan NM, Woo KM, Holodny AI Abstract Purpose To evaluate the effects of histologic features and anatomic magnetic resonance (MR) imaging characteristics of brain tumors on the functional MR imaging signal in the primary motor cortex (PMC), as false-negative blood oxygen level-dependent (BOLD) functional MR imaging activation can limit the accurate localization of... περισσότερα »
Application of Machine Learning to Arterial Spin Labeling in Mild Cognitive Impairment and Alzheimer Disease.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Application of Machine Learning to Arterial Spin Labeling in Mild Cognitive Impairment and Alzheimer Disease.* Radiology. 2016 Jul 6;:152703 Authors: Collij LE, Heeman F, Kuijer JP, Ossenkoppele R, Benedictus MR, Möller C, Verfaillie SC, Sanz-Arigita EJ, van Berckel BN, van der Flier WM, Scheltens P, Barkhof F, Wink AM Abstract Purpose To investigate whether multivariate pattern recognition analysis of arterial spin labeling (ASL) perfusion maps can be used for classification and single-subject prediction of patients with Alzheimer disease (AD) and mild cognitive impairment (MCI... περισσότερα »
Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus.* Radiology. 2016 Jul 7;:151951 Authors: Fraga de Abreu VH, Peck KK, Petrovich-Brennan NM, Woo KM, Holodny AI Abstract Purpose To evaluate the effects of histologic features and anatomic magnetic resonance (MR) imaging characteristics of brain tumors on the functional MR imaging signal in the primary motor cortex (PMC), as false-negative blood oxygen level-dependent (BOLD) functional MR imaging activation can limit the accurate localization of... περισσότερα »
Application of Machine Learning to Arterial Spin Labeling in Mild Cognitive Impairment and Alzheimer Disease.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Application of Machine Learning to Arterial Spin Labeling in Mild Cognitive Impairment and Alzheimer Disease.* Radiology. 2016 Jul 6;:152703 Authors: Collij LE, Heeman F, Kuijer JP, Ossenkoppele R, Benedictus MR, Möller C, Verfaillie SC, Sanz-Arigita EJ, van Berckel BN, van der Flier WM, Scheltens P, Barkhof F, Wink AM Abstract Purpose To investigate whether multivariate pattern recognition analysis of arterial spin labeling (ASL) perfusion maps can be used for classification and single-subject prediction of patients with Alzheimer disease (AD) and mild cognitive impairment (MCI... περισσότερα »
Temporal patterns of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Temporal patterns of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy.* Int Forum Allergy Rhinol. 2016 Jul 7; Authors: Schwartz JS, Brooks SG, Stubbs V, Ghosh A, Tajudeen BA, Khalili S, Palmer JN, Lee JY, Nabavizadeh SA, Learned KO, Adappa ND Abstract BACKGROUND: Current guidelines have identified 10 to 12 weeks posttreatment as the ideal time-point for improved diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) for deep tissue sites of the head and neck. After treatm... περισσότερα »
Temporal patterns of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Temporal patterns of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy.* Int Forum Allergy Rhinol. 2016 Jul 7; Authors: Schwartz JS, Brooks SG, Stubbs V, Ghosh A, Tajudeen BA, Khalili S, Palmer JN, Lee JY, Nabavizadeh SA, Learned KO, Adappa ND Abstract BACKGROUND: Current guidelines have identified 10 to 12 weeks posttreatment as the ideal time-point for improved diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) for deep tissue sites of the head and neck. After treatm... περισσότερα »
Thyroarytenoid muscle uptake and attenuation in PET/CT in elderly.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Thyroarytenoid muscle uptake and attenuation in PET/CT in elderly.* Eur Arch Otorhinolaryngol. 2016 Jul 6; Authors: Ziade G, Semaan S, Fakhri G, Natout TE, Hamdan AL Abstract The objective of this study is to compare uptake and attenuation on positron emission tomography/computed tomography (PET/CT) imaging modality at the thyroarytenoid muscle between subjects aged less and older than 65 years old. The study design is retrospective chart review. The setting is academic medical center. PET/CT images of 60 patients aged less than 65 years old and 60 patients aged more than 65 year... περισσότερα »
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland.* Otolaryngol Pol. 2016;70(0):24-28 Authors: Wiatr M, Gawlik R, Boroń A, Wiatr A, Składzień J Abstract BACKGROUND: Otosclerosis is the most common cause of condactive hearing loss between 15 and 50 years old. The most common symptoms are hearinglosss and tinnitus. Surgery is currently the preferred treatment method. AIM: The aim of our study was to analyze the outcomes of patients treated surgically due to otosclerosis in te... περισσότερα »
Classification of congenital nasal deformities: a proposal to amend the existing classification.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Classification of congenital nasal deformities: a proposal to amend the existing classification.* Eur Arch Otorhinolaryngol. 2016 Jul 6; Authors: Fijałkowska M, Antoszewski B Abstract Congenital nasal anomalies are rare malformations with a broad spectrum of defects. The only existing classification strictly relating to nasal anomalies was presented by Losee et al. (Plast Reconstr Surg 113(2):676-689, 2004). The aim of this paper is to propose some suggestions, based on our current knowledge and experience gained by treating our patients in the clinic, in creating a specificatio... περισσότερα »
Contemporary Neuroradiographic Assessment of the Cochleo-Carotid Partition.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Contemporary Neuroradiographic Assessment of the Cochleo-Carotid Partition.* ORL J Otorhinolaryngol Relat Spec. 2016 Jul 7;78(4):193-198 Authors: Shoman NM, Samy RN, Pensak ML Abstract PURPOSE: The cochleo-carotid partition (CCP) describes the intimate anatomic relationship between the petrous carotid artery and the cochlear basal turn. This partition bears significant surgical and unique clinical relevance. The purpose of this paper is to radiographically assess the CCP and discuss its clinical implications. METHODS: A total of 155 consecutive fine-cut temporal bone CT scans wer... περισσότερα »
[Clinical characteristics of 100 vestibular migraine cases].
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*[Clinical characteristics of 100 vestibular migraine cases].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):399-401 Authors: Chen J, Gong D, Cai S, Wu Z, Lin X, Ma X, Yu L Abstract OBJECTIVE: To analyze the characteristics of vestibular migraine (VM), in order to understand the auditory and vestibular function. METHOD: One hundred cases of confirmed or suspected VM patients were observed. Routine examination including pure tone test, vestibular dual temperature test and vestibular evoked myogenic potential(VEMP) and video head impulse test(v-HIT) Were conducted. R... περισσότερα »
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie.* Sci Rep. 2016;6:28711 Authors: Schmitz M, Cramm M, Llorens F, Candelise N, Müller-Cramm D, Varges D, Schulz-Schaeffer WJ, Zafar S, Zerr I Abstract In vitro amplification assays, such as real-time quaking-induced conversion (RT-QuIC) are used to detect aggregation activity of misfolded prion protein (PrP) in brain, cerebrospinal fluid (CSF) and urine samples from patients with a prion disease. We believe that the method also has a much b... περισσότερα »
[Prevalence of bilateral abnormalities of unilateral Meniére disease].
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*[Prevalence of bilateral abnormalities of unilateral Meniére disease].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):383-5 Authors: Ma X, Wu Z, Liu X, Chen X, Xu D Abstract OBJECTIVE: To analyze the abnormal conditions of the affected ear and the contralateral ear of patients with unilateral Meniere's disease and the prevalence of bilateral abnormalities among these unilateral Meniere disease population, providing reference for the clinical treatment strategies for Meniére disease. METHOD: A retrospective analysis of 106 Meni6re disease cases was performed, the ... περισσότερα »
Classification of congenital nasal deformities: a proposal to amend the existing classification.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 26 δευτερόλεπτα
*Classification of congenital nasal deformities: a proposal to amend the existing classification.* Eur Arch Otorhinolaryngol. 2016 Jul 6; Authors: Fijałkowska M, Antoszewski B Abstract Congenital nasal anomalies are rare malformations with a broad spectrum of defects. The only existing classification strictly relating to nasal anomalies was presented by Losee et al. (Plast Reconstr Surg 113(2):676-689, 2004). The aim of this paper is to propose some suggestions, based on our current knowledge and experience gained by treating our patients in the clinic, in creating a specificatio... περισσότερα »
Etiology and Management of Allergic Eyelid Dermatitis.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Purpose: Allergic dermatitis is a common but often misdiagnosed condition that can present with a variety of findings including inflammation, eyelid malposition, and tearing. This study was performed to identify likely etiologies, along with presenting findings and treatment strategies for allergic dermatitis. Methods: A retrospective review of clinical records was performed of patients diagnosed with […]
Application of Nipple Retractor for Correction of Nipple Inversion: A 10-Year Experience
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background Nipple inversion is a relatively common problem in adolescent and adult women; however, most present surgical treatments are prone to injure the lactiferous ducts and impair the breast feeding function. A nipple retractor was developed by us in 2003 to correct nipple inversion to avoid lactiferous duct injury. The details and a 10-year […]
Evaluation of the clinical utility of the Home Falls and Accidents Screening Tool (HOME FAST).
*Evaluation of the clinical utility of the Home Falls and Accidents Screening Tool (HOME FAST).* Disabil Rehabil. 2016 Jul 6;:1-13 Authors: Mackenzie L Abstract PURPOSE: The HOME FAST was developed and trialled in Australia as a screening tool designed to be used by any health professional to identify older people at increased risk of falls and to facilitate referral for more detailed assessment and intervention. This study aimed to evaluate the clinical utility of the HOME FAST from the perspective of users. METHOD: A mixed-methods approach using survey data (n = 32), focus group... περισσότερα »
Collaborative goal setting with and for children as part of therapeutic intervention.
*Collaborative goal setting with and for children as part of therapeutic intervention.* Disabil Rehabil. 2016 Jul 6;:1-12 Authors: Costa UM, Brauchle G, Kennedy-Behr A Abstract PURPOSE: This study explored collaborative goal setting with children, parents, and teachers, and children's reasons for their goals based on their perceived self-efficacy, using the Austrian-German Perceived Efficacy and Goal Setting System (AG-PEGS). METHOD: Thirty-eight children from age 5 to 10 years (referred to occupational therapists because of difficulties in performing everyday activities), their ... περισσότερα »
Effects of four-month handbike training under free-living conditions on physical fitness and health in wheelchair users.
*Effects of four-month handbike training under free-living conditions on physical fitness and health in wheelchair users.* Disabil Rehabil. 2016 Jul 6;:1-8 Authors: Hoekstra S, Valent L, Gobets D, van der Woude L, de Groot S Abstract PURPOSE: Recognizing the encouraging effect of challenging events, the HandbikeBattle (HBB) was created to promote exercise among wheelchair users. The purpose of this study was to reveal the effects on physical fitness and health outcomes of four-month handbike training under free-living conditions in preparation for the event. METHODS: In this prosp... περισσότερα »
Long-term impact of stroke on patients' health-related quality of life.
*Long-term impact of stroke on patients' health-related quality of life.* Disabil Rehabil. 2016 Jul 6;:1-6 Authors: De Wit L, Theuns P, Dejaeger E, Devos S, Gantenbein AR, Kerckhofs E, Schuback B, Schupp W, Putman K Abstract PURPOSE: This international study aims to examine the size and determinants of the impact of stroke on five-year survivors' health-related quality of life (HRQoL) in four different European countries. METHOD: Patients were recruited consecutively in four European rehabilitation centers. Five years after stroke, the EuroQol-visual analog scale (EQ-VAS) was admi... περισσότερα »
Embedding technology into inter-professional best practices in home safety evaluation.
*Embedding technology into inter-professional best practices in home safety evaluation.* Disabil Rehabil Assist Technol. 2016 Jul 6;:1-7 Authors: Burns SP, Pickens ND Abstract PURPOSE: To explore inter-professional home evaluators' perspectives and needs for building useful and acceptable decision-support tools for the field of home modifications. METHOD: Twenty semi-structured interviews were conducted with a range of home modification professionals from different regions of the United States. The interview transcripts were analyzed with a qualitative, descriptive, perspective a... περισσότερα »
Identifying non-pharmacological risk factors for falling in older adults with type 2 diabetes mellitus: a systematic review.
*Identifying non-pharmacological risk factors for falling in older adults with type 2 diabetes mellitus: a systematic review.* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Gravesande J, Richardson J Abstract PURPOSE: To identify the non-pharmacological risk factors for falling in older adults with type 2 diabetes mellitus (DM2). METHODS: A systematic review of randomized controlled trials, prospective cohort studies, cross-sectional studies and before/after studies was conducted. Eligible studies identified non-pharmacological risk factors for falling in older adults with DM2. Medlin... περισσότερα »
An international survey of patients living with spasticity.
*An international survey of patients living with spasticity.* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Barnes M, Kocer S, Murie Fernandez M, Balcaitiene J, Fheodoroff K Abstract PURPOSE: To better understand patient perspectives on the life impact of spasticity. METHODS: Global Internet survey (April 2014-May 2015) of 281 people living with spasticity. RESULTS: Respondents indicated that spasticity has a broad impact on their daily-life: 72% reported impact on quality of life, 44% reported loss of independence and 44% reported depression. Most respondents (64%) were cared for by ... περισσότερα »
Surgery or conservative treatment for rotator cuff tear: a meta-analysis.
*Surgery or conservative treatment for rotator cuff tear: a meta-analysis.* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Ryösä A, Laimi K, Äärimaa V, Lehtimäki K, Kukkonen J, Saltychev M Abstract PURPOSE: Comparative evidence on treating rotator cuff tear is inconclusive. The objective of this review was to evaluate the evidence on effectiveness of tendon repair in reducing pain and improving function of the shoulder when compared with conservative treatment of symptomatic rotator cuff tear. METHOD: Search on CENTRAL, MEDLINE, EMBASE, CINAHL, Web of Science and Pedro databases. Rando... περισσότερα »
Improving the quality of life and psychological well-being of recently diagnosed multiple sclerosis patients: preliminary evaluation of a group-based cognitive behavioral intervention.
*Improving the quality of life and psychological well-being of recently diagnosed multiple sclerosis patients: preliminary evaluation of a group-based cognitive behavioral intervention.* Disabil Rehabil. 2016 Jul 6;:1-8 Authors: Calandri E, Graziano F, Borghi M, Bonino S Abstract PURPOSE: The study evaluated a group-based cognitive behavioral intervention aimed at promoting the quality of life and the psychological well-being of recently diagnosed multiple sclerosis (MS) patients (up to 3 years since the diagnosis). METHOD: The study involved 85 patients [59% women; mean age 37, S... περισσότερα »
Walking activity during daily living in children with myelomeningocele.
*Walking activity during daily living in children with myelomeningocele.* Disabil Rehabil. 2016 Jul 6;:1-6 Authors: Yasmeh P, Mueske NM, Yasmeh S, Ryan DD, Wren TA Abstract PURPOSE: To quantify the walking activity of children with myelomeningocele during daily living. METHOD: Walking activity was measured using a StepWatch activity monitor over one week in 47 children with myelomeningocele (27 males; 9 years 11 months SD 2 years 7 months; 18 sacral, 9 low lumbar, 20 mid-high lumbar) and seven children with typical development (5 males; 11 years 1 month SD 1 year 11 months) in a p... περισσότερα »
Reliability and validity of the Finnish version of the Lower Extremity Functional Scale (LEFS).
*Reliability and validity of the Finnish version of the Lower Extremity Functional Scale (LEFS).* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Repo JP, Tukiainen EJ, Roine RP, Ilves O, Järvenpää S, Häkkinen A Abstract PURPOSE: The present study aimed to assess the psychometric properties of the Finnish version of the Lower Extremity Functional Scale (LEFS) among foot and ankle patients. METHODS: The LEFS was translated and cross-culturally adapted to Finnish. We assessed the test-retest reliability, internal consistency, floor-ceiling effect, construct validity and criterion validity... περισσότερα »
Referral decision support in patients with subacute brain injury: evaluation of the Rehabilitation Complexity Scale - Extended.
*Referral decision support in patients with subacute brain injury: evaluation of the Rehabilitation Complexity Scale - Extended.* Disabil Rehabil. 2016 Jul 6;:1-7 Authors: Pedersen AR, Nielsen JF, Jensen J, Maribo T Abstract PURPOSE: To test if the Rehabilitation Complexity Scale Extended (RCS-E) can be used as decision support for patient referral to primary rehabilitation as either complex specialized services (CSS) or district specialist services (DSS). METHOD: Two independent expert teams analyzed medical records on 299 consecutive patients admitted for CSS or DSS rehabilitati... περισσότερα »
Patient experience after lower extremity amputation for sarcoma in England: a national survey.
*Patient experience after lower extremity amputation for sarcoma in England: a national survey.* Disabil Rehabil. 2016 Jul 6;:1-20 Authors: Furtado S, Briggs T, Fulton J, Russell L, Grimer R, Wren V, Cool P, Grant K, Gerrand C Abstract PURPOSE: After amputation, rehabilitation and limb fitting services are critically important to optimise outcomes. We investigated the reported patient experience and variation in limb fitting services after amputation for musculoskeletal tumours in England. METHODS: A postal survey instrument was developed following literature review, patient and ... περισσότερα »
Need for an Australian Indigenous disability workforce strategy: review of the literature.
*Need for an Australian Indigenous disability workforce strategy: review of the literature.* Disabil Rehabil. 2016 Jul 6;:1-10 Authors: Gilroy J, Dew A, Lincoln M, Hines M Abstract PURPOSE: To identify approaches for developing workforce capacity to deliver the National Disability Insurance Scheme (NDIS) to Indigenous people with disability in Australian rural and remote communities. METHOD: A narrative review of peer-reviewed and gray literature was undertaken. Searches of electronic databases and websites of key government and non-government organizations were used to supplement... περισσότερα »
Optimal Selection of Radiotherapy as Part of a Multimodal Approach for Hepatocellular Carcinoma.
*Optimal Selection of Radiotherapy as Part of a Multimodal Approach for Hepatocellular Carcinoma.* Liver Cancer. 2016 Apr;5(2):139-151 Authors: Yoon HI, Seong J Abstract A multimodal approach to treatment is a basic oncologic principle with proven survival benefits for most cancer types. However, existing guidelines recommend single modalities for treating each stage of hepatocellular carcinoma (HCC). Nonetheless, multimodal approaches can be considered for HCC, depending on the characteristics of the disease in individual cases. Radiotherapy (RT), an effective local modality, is... περισσότερα »
Restoration of Mitral Inflow Velocity Until Blanking Period Is Associated With Successful Ablation for Persistent Atrial Fibrillation.
*Restoration of Mitral Inflow Velocity Until Blanking Period Is Associated With Successful Ablation for Persistent Atrial Fibrillation.* Int Heart J. 2016 Jul 7; Authors: Kim JY, Kim SH, Jung HO, Oh YS, Lee MY, Youn HJ Abstract Radiofrequency catheter ablation (RFCA) is a useful therapeutic option for atrial fibrillation (AF), although outcomes are less effective for persistent AF. The aim of this study was to elucidate the echocardiographic parameters associated with successful RFCA in patients with persistent AF.A total of 159 patients (mean age, 60.8 ± 9.6 years, 125 males [78.... περισσότερα »
Combined CT-guided radiofrequency ablation with systemic chemotherapy improves the survival for nasopharyngeal carcinoma with oligometastasis in liver: Propensity score matching analysis.
*Combined CT-guided radiofrequency ablation with systemic chemotherapy improves the survival for nasopharyngeal carcinoma with oligometastasis in liver: Propensity score matching analysis.* Oncotarget. 2016 Jul 2; Authors: Li W, Bai Y, Wu M, Shen L, Shi F, Sun X, Lin C, Chang B, Pan C, Li Z, Wu P Abstract The aim of this study was to retrospectively compare the treatment efficacy of systemic chemotherapy combined with sequential CT-guided radiofrequency ablation (Chemo-RFA) to chemotherapy alone (Chemo-only) in the management of nasopharyngeal carcinoma (NPC) with liver metastasi... περισσότερα »
Effects of local radiofrequency denervation on ventricular electrophysiological properties in normal and acute myocardial ischemia heart.
*Effects of local radiofrequency denervation on ventricular electrophysiological properties in normal and acute myocardial ischemia heart.* Eur Rev Med Pharmacol Sci. 2016 Jun;20(12):2673-2679 Authors: Huang Y, Wang DN, Liu P, Song Y, Cui HM, Zhang JY, Blackwell J, Liao DN Abstract OBJECTIVE: To observe the effects of local radiofrequency denervation on ventricular effective refractory periods, electrical alternans and ventricular arrhythmia susceptibility post myocardial infarction. MATERIALS AND METHODS: Thirty-four mongrel dogs were randomly divided into the normal heart group... περισσότερα »
Tumor Heterogeneity in Hepatocellular Carcinoma: Facing the Challenges.
*Tumor Heterogeneity in Hepatocellular Carcinoma: Facing the Challenges.* Liver Cancer. 2016 Apr;5(2):128-138 Authors: Lu LC, Hsu CH, Hsu C, Cheng AL Abstract Tumor heterogeneity in hepatocellular carcinoma (HCC), such as that found in second primary tumors after curative treatment, synchronous multifocal tumors of different clonality, or intratumor heterogeneity, poses severe challenges for the development and administration of systemic molecular targeted therapies. Various methodologies, including historical DNA ploidy analysis, integrated hepatitis B virus DNA analysis, DNA fin... περισσότερα »
Patient/Family Education for Newly Diagnosed Pediatric Oncology Patients: Consensus Recommendations from a Children's Oncology Group Expert Panel.
*Patient/Family Education for Newly Diagnosed Pediatric Oncology Patients: Consensus Recommendations from a Children's Oncology Group Expert Panel.* J Pediatr Oncol Nurs. 2016 Jul 5; Authors: Landier W, Ahern J, Barakat LP, Bhatia S, Bingen KM, Bondurant PG, Cohn SL, Dobrozsi SK, Haugen M, Herring RA, Hooke MC, Martin M, Murphy K, Newman AR, Rodgers CC, Ruccione KS, Sullivan J, Weiss M, Withycombe J, Yasui L, Hockenberry M Abstract There is a paucity of data to support evidence-based practices in the provision of patient/family education in the context of a new childhood cancer d... περισσότερα »
Adverse events risk associated with angiogenesis inhibitors addition to therapy in ovarian cancer: a meta-analysis of randomized controlled trials.
*Adverse events risk associated with angiogenesis inhibitors addition to therapy in ovarian cancer: a meta-analysis of randomized controlled trials.* Eur Rev Med Pharmacol Sci. 2016 Jun;20(12):2701-2709 Authors: Liang XJ, Shen J Abstract OBJECTIVE: Inhibition of angiogenesis has been regarded as an attractive treatment strategy for advanced or recurrent ovarian cancer. We conduct this meta-analysis to investigate the risk of adverse events of special interest related to angiogenesis inhibitors (AIs) in ovarian cancer. PATIENTS AND METHODS: Databases from PubMed, Web of Science and ... περισσότερα »
A qualitative investigation of decision making during help-seeking for adult hearing loss.
*A qualitative investigation of decision making during help-seeking for adult hearing loss.* Int J Audiol. 2016 Jul 6;:1-9 Authors: Pryce H, Hall A, Laplante-Lévesque A, Clark E Abstract OBJECTIVE: The Any Qualified Provider framework in the National Health Service has changed the way adult audiology services are offered in England. Under the new rules, patients are being offered a choice in geographical location and audiology provider. This study aimed to explore how choices in treatment are presented and to identify what information patients need when they are seeking help with... περισσότερα »
A qualitative investigation of decision making during help-seeking for adult hearing loss.
*A qualitative investigation of decision making during help-seeking for adult hearing loss.* Int J Audiol. 2016 Jul 6;:1-9 Authors: Pryce H, Hall A, Laplante-Lévesque A, Clark E Abstract OBJECTIVE: The Any Qualified Provider framework in the National Health Service has changed the way adult audiology services are offered in England. Under the new rules, patients are being offered a choice in geographical location and audiology provider. This study aimed to explore how choices in treatment are presented and to identify what information patients need when they are seeking help with... περισσότερα »
Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition.
*Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition.* Thorac Cancer. 2016 Jul;7(4):379-386 Authors: Li Y, Liu F, Wang Y, Li D, Guo F, Xu L, Zeng Z, Zhong X, Qian K Abstract BACKGROUND: Autophagy has been reported to increase in cancer cells after radiation. However, it remains unknown whether increased autophagy as a result of radiation affects DNA damage repair and sensitizes cancer cells. In this study, the radiosensitization effect of rapamycin, a mammalian target of rapamycin inhibitor that induces autophagy, on human lu... περισσότερα »
Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy.
*Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy.* Proc Natl Acad Sci U S A. 2016 Jul 6; Authors: Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH Abstract The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is central to autophagy initiation. We previously reported the V-shaped architecture of the four-subunit version of PI3KC3-C1 consisting of VPS (vacuolar protein sorting) 34, VPS15, BECN1 (Beclin 1), and ATG (autophagy-related) 14. Here we show that a putative fifth subunit, nuclear receptor binding factor 2 ... περισσότερα »
The Diagnostic Yield of Commonly Used Investigations in Pelvic Gunshot Wounds.
Background: Patients who sustain pelvic gunshot wounds (GSWs) are at significant risk for injury due to the density of pelvic structures. Currently, the optimal work-up for pelvic GSWs is unclear. The aim of this study was to determine the diagnostic yield of tests commonly used in the investigation of pelvic GSWs and to develop a diagnostic algorithm. Methods: All patients >=15 years old presenting to LAC+USC Medical Center (01/2008-02/2015) who sustained >=1 pelvic GSW were retrospectively identified. Patient demographics, clinical assessment, investigations, procedures, and outco... περισσότερα »
Stress among surgical attendings and trainees: A quantitative assessment during trauma activation and emergency surgeries.
BACKGROUND: The adverse effects of stress on the wellness of trauma team members is well established, however, the level of stress has never been quantitatively assessed. The aim of our study was to assess the level of stress using subjective data and objective heart rate variability (HRV) among attending surgeons (AS), junior (JR) (PGY2/PGY3), and senior (SR) (PGY5/PGY6) residents during trauma activation and emergency surgery. METHODS: We preformed a prospective study enrolling participants over eight 24-hour calls in our Level-1 trauma center. Stress was assessed based on decreas... περισσότερα »
Reply re: “Histopathology and Immunophenotyping of Congenital Lacrimal (Anlage) Fistulae”
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
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Editorial Board
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
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A position paper on drug allergy – pinpointing problems rather than suggesting solutions
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
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Table of Contents
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
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Comparison between a count-based and geometrical approach for the assessment of left ventricular dyssynchrony using myocardial perfusion scintigraphy.
*Comparison between a count-based and geometrical approach for the assessment of left ventricular dyssynchrony using myocardial perfusion scintigraphy.* Nucl Med Commun. 2016 Jul 4; Authors: Nguyên UC, Al Younis I, Ajmone-Marsan N, Dibbets-Schneider P, Blokland JA, de Wit-van der Veen BJ Abstract OBJECTIVE: There are two distinct approaches for the assessment of left ventricular (LV) dyssynchrony by myocardial perfusion scintigraphy (MPS). The aim of this study was to compare the performance of the count-based and geometrical approach in clinical data using gated single photon em... περισσότερα »
The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.
*The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.* Nucl Med Commun. 2016 Jul 4; Authors: Stangierski A, Kaznowski J, Wolinski K, Jodlowska E, Michaliszyn P, Kubiak K, Czepczynski R, Ruchala M Abstract INTRODUCTION: PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) des... περισσότερα »
SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice.
*SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice.* Oncotarget. 2016 Jul 1; Authors: Ke M, Wang H, Zhou Y, Li J, Liu Y, Zhang M, Dou J, Xi T, Shen B, Zhou C Abstract Chemotherapy and immunotherapy are the main remedies used in cancer treatment. Because immunotherapy can not only reduce the toxicity of chemotherapeutics but also enhance antitumor effects in vivo, combining these two therapies is a trend that continues to gain more attention in clinic. SEP, a polysaccharide is... περισσότερα »
FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma.
*FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma.* Oncotarget. 2016 Jul 1; Authors: Lin CH, Lin YW, Chen YC, Liao CC, Jou YS, Hsu MT, Chen CF Abstract Recurrence and metastasis are common in hepatocellular carcinoma (HCC) and correlate with poor prognosis. We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in HCC metastasis. Overexpression of FNDC3B in HCC cell lines enhanced cell migration and invasion. On the other hand, knockdown of FNDC3B using short-hairpin RNA reduced tumor nodule formation in both intra- and extra... περισσότερα »
Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer.
*Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer.* Oncotarget. 2016 Jul 1; Authors: Wookyeom Y, Hanbyoul C, Ha-Yeon S, Joon-Yong C, Kang ES, Eun-Ju L, Jae-Hoon K Abstract Cyclin dependent kinase 1 (Cdk1) have previously reported correlation with cancer growth and a key regulator for cell cycle. Mostly, Cdk1's function of nucleus for cell cycle is well known to be associated with cancer, but cytoplasmic Cdk1's traits are not clearly identified, yet. We revealed that tissue microarray blocks of epithelial ovarian canc... περισσότερα »
CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells.
*CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells.* Oncotarget. 2016 Jul 1; Authors: Zaborsky N, Gassner FJ, Asslaber D, Reinthaler P, Denk U, Flenady S, Hofbauer JP, Danner B, Rebhandl S, Harrer A, Geisberger R, Greil R, Egle A Abstract Chronic lymphocytic leukemia develops within a complex network driven by genetic mutations and microenvironmental interactions. Among the latter a complex interplay with the immune system is established by the clone. Next to a propose... περισσότερα »
Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.
*Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.* Oncotarget. 2016 Jul 1; Authors: Cheng W, Tian L, Wang B, Qi Y, Huang W, Li H, Chen YJ Abstract Heterochromatin protein 1α (HP1α) is a gene that mediates chromatin conformation, gene silencing and cancer progression. However, little is known regarding the impact of HP1α in the pathogenesis of cholangiocarcinoma (CCA). In the present study, we demonstrate that HP1α is significantly upregulated in CCA tissues and cell lines, while downregulation of HP1α leads to suppression of cel... περισσότερα »
Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma.
*Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma.* Oncotarget. 2016 Jul 1; Authors: Gasparini P, Casanova M, Villa R, Collini P, Alaggio R, Zin A, Bonvini P, Antonescu CR, Boldrini R, Caserini R, Moro M, Centonze G, Meazza C, Massimino M, Bergamaschi L, Luksch R, Chiaravalli S, Bisogno G, Zaffaroni N, Daidone M, Sozzi G, Ferrari A Abstract Rhabdomyosarcoma (RMS) is the most frequent soft tissue tumor in childhood and arises from immature mesenchymal cells committed to skeletal muscle differentiation. Anaplastic Lymphoma Kina... περισσότερα »
Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1.
*Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1.* Oncotarget. 2016 Jul 1; Authors: Chen G, Gong R, Shi X, Yang D, Zhang G, Lu A, Yue J, Bian Z Abstract Combinational drug therapy is one of the most promising strategies in modern anticancer research. Traditional Chinese medicine (TCM) formulas represent a wealth of complex combinations proven successful over centuries of clinical application. One such formula used to treat a variety of diseases, including cancer, contains two herbs, whose main active componen... περισσότερα »
Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.
*Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.* Oncotarget. 2016 Jul 1; Authors: Pitts TM, Bradshaw-Pierce EL, Bagby SM, Hyatt SL, Selby HM, Spreafico A, Tentler JJ, McPhillips K, Klauck PJ, Capasso A, Diamond JR, Davis SL, Tan AC, Arcaroli JJ, Purkey A, Messersmith WA, Ecsedy JA, Eckhardt SG Abstract BACKGROUND: The Aurora kinases are a family of serine/threonine kinases comprised of Aurora A, B, and C which execute critical steps in mitotic and meiotic progression. Alisertib (MLN8237) is an investigati... περισσότερα »
Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.
*Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.* Oncotarget. 2016 Jul 1; Authors: Hooren LV, Georganaki M, Huang H, Mangsbo SM, Dimberg A Abstract CD40-activating immunotherapy has potent antitumor effects due to its ability to activate dendritic cells and induce cytotoxic T-cell responses. However, its efficacy is limited by immunosuppressive cells in the tumor and by endothelial anergy inhibiting recruitment of T-cells. Here, we show that combining agonistic CD4... περισσότερα »
Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases.
*Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases.* Oncotarget. 2016 Jul 1; Authors: Zhang W, Lv Y, Xue Y, Wu C, Yao K, Zhang C, Jin Q, Huang R, Li J, Sun Y, Su X, Jiang T, Fan X Abstract Inter-individual variability causing elevated signaling of receptor tyrosine kinases (RTK) may have hampered the efficacy of targeted therapies. We developed a molecular signature for clustering adult diffuse gliomas based on the extent of RTK pathway activities. Glioma gene modules co-express... περισσότερα »
Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer.
*Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer.* Oncotarget. 2016 Jul 2; Authors: Liang Y, Wang W, Fang C, Raj SS, Hu WM, Li QW, Zhou ZW Abstract AIMS: To evaluate the clinical significance of multiple serum tumor markers (TMs) in the diagnosis of gastric cancer (GC) and establish an accurate discriminant equation to identify the presence of GC. RESULTS: The serum levels of CEA, CA19-9 and CA72-4 were higher in the GC group than in the control group (P < 0.005). The sensitivity of CEA, CA19-9 and CA72-4 in the diagnosis ... περισσότερα »
Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.
*Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.* Oncotarget. 2016 Jul 2; Authors: Lueck SC, Russ AC, Botzenhardt U, Schlenk RF, Zobel K, Deshayes K, Vucic D, Döhner H, Döhner K, Fulda S, Bullinger L Abstract Apoptosis is deregulated in most, if not all, cancers, including hematological malignancies. Smac mimetics that antagonize Inhibitor of Apoptosis (IAP) proteins have so far largely been investigated in acute myeloid leukemia (AML) cell lines; however, little is yet known on the ... περισσότερα »
The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models.
*The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models.* Oncotarget. 2016 Jul 2; Authors: Zhu YR, Zhou XZ, Zhu LQ, Yao C, Fang JF, Zhou F, Deng XW, Zhang YQ Abstract In the present study, we investigated the activity of XL388, a novel mammalian target of rapamycin (mTOR) complex 1/2 (mTORC1/2) dual inhibitor, in preclinical osteosarcoma (OS) models. XL388 was cytotoxic, cytostatic and pro-apoptotic to multiple established OS cell lines and primary human OS cells. XL388 blocked mTORC1/2 activation and downregulated cyclin D1/B1 expression... περισσότερα »
TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells.
*TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells.* Oncotarget. 2016 Jul 2; Authors: Pinet S, Bessette B, Vedrenne N, Lacroix A, Richard L, Jauberteau MO, Battu S, Lalloué F Abstract The neurotrophin receptors are known to promote growth and proliferation of glioblastoma cells. Their functions in spreading glioblastoma cell aggressiveness to the microenvironment through exosome release from glioblastoma cells are unknown.Considering previous reports demonstrating that YKL-40 expression is associated with undiffe... περισσότερα »
ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.
*ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.* Oncotarget. 2016 Jul 2; Authors: Xu G, Lu X, Huang T, Fan J Abstract Renal cell carcinoma (RCC) is the major cause of kidney malignancy-related deaths. Rho GTPases are key regulators in cancer cell metastasis. ARHGAP24, a Rac-specific member of the Rho GTPase-activating protein family, acts as a functional target of cancer cell migration and invasion. In the present study, we identified ARHGAP24 expression is downregulated in renal cancer tissues and is highly correlated... περισσότερα »
5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53.
*5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53.* Oncotarget. 2016 Jul 2; Authors: Pagliara V, Saide A, Mitidieri E, d'Emmanuele di Villa Bianca R, Sorrentino R, Russo G, Russo A Abstract Recent findings revealed in cancer cells novel stress response pathways, which in response to many chemotherapeutic drugs causing nucleolar stress, will function independently from tumor protein p53 (p53) and still lead to cell cycle arrest and/or apoptosis. Since it is known that most cancers lack functional p53, it is of great... περισσότερα »
Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells.
*Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells.* Oncotarget. 2016 Jul 2; Authors: Gutkin A, Uziel O, Beery E, Nordenberg J, Pinchasi M, Goldvaser H, Henick S, Goldberg M, Lahav M Abstract Exosomes are small (30-100nm) vesicles secreted from all cell types serving as inter-cell communicators and affecting biological processes in "recipient" cells upon their uptake. The current study demonstrates for the first time that hTERT mRNA, the transcript of the enzyme telomerase, is shuttled from cancer cells via exoso... περισσότερα »
Combined CT-guided radiofrequency ablation with systemic chemotherapy improves the survival for nasopharyngeal carcinoma with oligometastasis in liver: Propensity score matching analysis.
*Combined CT-guided radiofrequency ablation with systemic chemotherapy improves the survival for nasopharyngeal carcinoma with oligometastasis in liver: Propensity score matching analysis.* Oncotarget. 2016 Jul 2; Authors: Li W, Bai Y, Wu M, Shen L, Shi F, Sun X, Lin C, Chang B, Pan C, Li Z, Wu P Abstract The aim of this study was to retrospectively compare the treatment efficacy of systemic chemotherapy combined with sequential CT-guided radiofrequency ablation (Chemo-RFA) to chemotherapy alone (Chemo-only) in the management of nasopharyngeal carcinoma (NPC) with liver metastasi... περισσότερα »
Reconstruction of Hypopharyngeal and Esophageal Defects Using a Gastric Tube after Total Esophagectomy and Pharyngolaryngectomy.
*Reconstruction of Hypopharyngeal and Esophageal Defects Using a Gastric Tube after Total Esophagectomy and Pharyngolaryngectomy.* ORL J Otorhinolaryngol Relat Spec. 2016 Jul 7;78(4):208-215 Authors: Liu J, Deng T, Li C, Peng L, Li Q, Zhu G, Wang W, Cai Y, Lan X, He Y, Wang Z, Wang S Abstract AIM: This study investigated the value of gastric tube during surgery for advanced hypopharyngeal and cervical esophageal cancer. METHOD: From November 2007 to December 2012, 42 patients underwent total pharyngo-laryngo-esophagectomy because of advanced hypopharyngeal or cervical esophageal c... περισσότερα »
Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.
*Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.* Oncotarget. 2016 Jul 1; Authors: McEntee G, Kyula JN, Mansfield D, Smith H, Wilkinson M, Gregory C, Roulstone V, Coffey M, Harrington KJ Abstract Oncolytic viruses selectively target and replicate in cancer cells, providing us with a unique tool with which to target and kill tumour cells. These viruses come from a diverse range of viral families including reovirus type 3 Dearing (RT3D), a non-pathogenic human double-strande... περισσότερα »
TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.
*TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.* Oncotarget. 2016 Jul 1; Authors: Schwartz AL, Dickerson E, Dagia N, Malgor R, McCall KD Abstract Heightened co-expression and dysregulated signaling associated with Toll-like receptor 3 (TLR3) and Wnt5a is an integral component of solid tumors and hematological malignancies. Our previous findings in pancreatic cancer and melanoma suggest that inhibition of these pathways by a TLR3 signaling inhibitor, phenylmethimazole (C10), results in significant... περισσότερα »
Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.
*Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.* Oncotarget. 2016 Jul 1; Authors: Hooren LV, Georganaki M, Huang H, Mangsbo SM, Dimberg A Abstract CD40-activating immunotherapy has potent antitumor effects due to its ability to activate dendritic cells and induce cytotoxic T-cell responses. However, its efficacy is limited by immunosuppressive cells in the tumor and by endothelial anergy inhibiting recruitment of T-cells. Here, we show that combining agonistic CD4... περισσότερα »
Late prostatic metastasis of an uveal melanoma in a miniature Schnauzer dog.
*Late prostatic metastasis of an uveal melanoma in a miniature Schnauzer dog.* Clin Case Rep. 2016 Jul;4(7):647-652 Authors: Delgado E, Silva JX, Pissarra H, Peleteiro MC, Dubielzig RR Abstract This manuscript describes a previously unreported clinical case of canine uveal melanoma in a miniature Schnauzer dog with an unusual location of metastasis (prostate) and delayed occurrence (3 years after primary tumor diagnosis and enucleation). Immunohistochemical labeling of both tumors with Melan A, Ki-67, and c-kit added some valuable information. PMID: 27386120 [PubMed - as supplied... περισσότερα »
Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice.
*Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice.* J Clin Aesthet Dermatol. 2016 Jun;9(6):25-30 Authors: Wilson JB, Walling HW, Scupham RK, Bean AK, Ceilley RI, Goetz KE Abstract Introduction: Lentigo maligna is a form of in situ melanoma that occurs commonly on sun-exposed skin of middle-aged to elderly adults. Margin-control surgery offers the highest cure rate for lentigo maligna/lentigo maligna melanoma. Materials and methods: Charts from the authors' private office from... περισσότερα »
Pulmonary malignant melanoma with distant metastasis assessed by positron emission tomography-computed tomography.
*Pulmonary malignant melanoma with distant metastasis assessed by positron emission tomography-computed tomography.* Thorac Cancer. 2016 Jul;7(4):503-507 Authors: Kim SR, Yoon HY, Jin GY, Choe YH, Park SY, Lee YC Abstract Melanoma is a cutaneous malignant neoplasm of melanocytes. Primary malignant melanoma (MM) of the lung is very rare. Although previous reports have described the radiologic features of pulmonary MM, its rarity means that many factors are unknown. Thus, radiologic diagnosis is very difficult. Furthermore, there is little information regarding diagnostic applicati... περισσότερα »
A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
*A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.* J Immunol. 2016 Jul 6; Authors: Liu JQ, Talebian F, Wu L, Liu Z, Li MS, Wu L, Zhu J, Markowitz J, Carson WE, Basu S, Bai XF Abstract CD200 is a cell surface glycoprotein that functions through engaging CD200R on cells of the myeloid lineage and inhibits their functions. Expression of CD200 was implicated in a variety of human cancer cells, including melanoma cells; however, its roles in tumor growth and immunity are not clearly understood. In this study, we used CD200R-deficient mice ... περισσότερα »
Beating A Cancer Death Sentence.
*Beating A Cancer Death Sentence.* Health Aff (Millwood). 2016 Jul 1;35(7):1333-1337 Authors: Friedlaender J Abstract A melanoma survivor describes his arduous-and costly-path to successful treatment and hope. PMID: 27385250 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/29n3oin
Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.
*Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.* Oncotarget. 2016 Jul 1; Authors: Hooren LV, Georganaki M, Huang H, Mangsbo SM, Dimberg A Abstract CD40-activating immunotherapy has potent antitumor effects due to its ability to activate dendritic cells and induce cytotoxic T-cell responses. However, its efficacy is limited by immunosuppressive cells in the tumor and by endothelial anergy inhibiting recruitment of T-cells. Here, we show that combining agonistic CD4... περισσότερα »
[Ethnic nail pigmentations and differential diagnoses].
*[Ethnic nail pigmentations and differential diagnoses].* Hautarzt. 2016 Jul 6; Authors: Dumke AK, Gina M, Goetze S, Schliemann S, Elsner P Abstract Pigmentary nail changes may have a variety of causes, e. g., chronic inflammation, and occur more often in patients of African descent compared to Caucasians. Subungual malignant melanoma is the most important differential diagnosis and must be ruled out in any case. Dermatoscopy might be helpful. If no biopsy is taken, clinical follow-ups are necessary at short intervals. In case of chronic paronychia, optimization of occupational s... περισσότερα »
TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.
*TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.* Oncotarget. 2016 Jul 1; Authors: Schwartz AL, Dickerson E, Dagia N, Malgor R, McCall KD Abstract Heightened co-expression and dysregulated signaling associated with Toll-like receptor 3 (TLR3) and Wnt5a is an integral component of solid tumors and hematological malignancies. Our previous findings in pancreatic cancer and melanoma suggest that inhibition of these pathways by a TLR3 signaling inhibitor, phenylmethimazole (C10), results in significant... περισσότερα »
Genomic Impact of Neoadjuvant Therapy on Breast Cancer: Incomplete Response is Associated with Altered Diagnostic Gene Signatures.
*Genomic Impact of Neoadjuvant Therapy on Breast Cancer: Incomplete Response is Associated with Altered Diagnostic Gene Signatures.* Ann Surg Oncol. 2016 Jul 6; Authors: Beitsch P, Whitworth P, Baron P, Pellicane J, Treece T, Yoder E, Gittleman M, NBRST Investigators Group Abstract PURPOSE: Neoadjuvant therapy (NAT) has been shown to clinically downstage locally advanced breast cancers. This study aimed to determine whether a meaningful change in gene signatures occurs between pre- and post-NAT breast cancers for patients who do not achieve a pathologic complete response. METHODS... περισσότερα »
Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.
*Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.* Oncotarget. 2016 Jul 1; Authors: McEntee G, Kyula JN, Mansfield D, Smith H, Wilkinson M, Gregory C, Roulstone V, Coffey M, Harrington KJ Abstract Oncolytic viruses selectively target and replicate in cancer cells, providing us with a unique tool with which to target and kill tumour cells. These viruses come from a diverse range of viral families including reovirus type 3 Dearing (RT3D), a non-pathogenic human double-strande... περισσότερα »
The Association of Multiple Melanocytic Nevi with Education, Skinburns and Sun Vacations. A Northern Finland Birth Cohort 1966 Study with 46 Years’ Follow-up.
*The Association of Multiple Melanocytic Nevi with Education, Skinburns and Sun Vacations. A Northern Finland Birth Cohort 1966 Study with 46 Years’ Follow-up.* Acta Derm Venereol. 2016 Jul 7; Authors: Sinikumpu SP, Huilaja L, Jokelainen J, Auvinen J, Timonen M, Tasanen K Abstract Having multiple melanocytic naevi (> 50 naevi) is one of the strongest risk factors for melanoma. However, their epidemiology in adults is unclear. This comprehensive dermatological status investigation of 1932 birth-cohort study cases aged 46 years analysed the prevalence of multiple melanocytic nae... περισσότερα »
Integrative analysis of subcellular quantitative proteomics studies reveals functional cytoskeleton membrane-lipid raft interactions in cancer.
*Integrative analysis of subcellular quantitative proteomics studies reveals functional cytoskeleton membrane-lipid raft interactions in cancer.* J Proteome Res. 2016 Jul 7; Authors: Shah AD, Inder KL, Shah AK, Cristino AS, McKie AB, Gabra H, Davis M, Hill MM Abstract Lipid rafts are dynamic membrane micro-domains that orchestrate molecular interactions, and are implicated in cancer development. To understand the functions of lipid rafts in cancer we performed an integrated analysis of quantitative lipid raft proteomics datasets modeling progression in breast cancer, melanoma and... περισσότερα »
Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
*Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.* Nature. 2016 Jul 6; Authors: Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Spe... περισσότερα »
Raman spectroscopic characterization of melanoma and benign melanocytic lesions suspected of melanoma using High-wavenumber Raman Spectroscopy.
*Raman spectroscopic characterization of melanoma and benign melanocytic lesions suspected of melanoma using High-wavenumber Raman Spectroscopy.* Anal Chem. 2016 Jul 6; Authors: Santos IP, Caspers PJ, Bakker Schut TC, van Doorn R, Noordhoek Hegt V, Koljenovic S, Puppels GJ Abstract Melanoma is a pigmented type of skin cancer, which has the highest mortality of all skin cancers. Due to the low clinical diagnostic accuracy for melanoma, an objective tool is needed to assist clinical assessment of skin lesions that are suspected of (early) melanoma. The aim of this study was to iden... περισσότερα »
Fine needle aspiration cytology guided by ultrasound in the diagnosis of subcentimetre thyroid nodules.
*Fine needle aspiration cytology guided by ultrasound in the diagnosis of subcentimetre thyroid nodules.* Springerplus. 2016;5(1):876 Authors: Li C, Zhan W, Yi F, Zheng B, Zhou Y, Zhao R, Jia Y Abstract BACKGROUND: This study aimed to investigate the value of fine needle aspiration biopsy (FNAB) under ultrasound guidance in diagnosis of thyroid nodules. In a retrospective analysis of FNAB in 1050 cases of patients with 1100 nodules, patients were divided according to the maximum diameter of their nodules into two groups: >1.0 and ≤1.0 cm. The ultrasound-guided FNAB cytology resul... περισσότερα »
Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature.
*Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature.* Thorac Cancer. 2016 Jul;7(4):508-511 Authors: Lim JH, Lee N, Choi DW, Oh HJ, Park HY, Kim KH, Kim TO, Park CK, Shin HJ, Choi YD, Yun JS, Song SY, Oh IJ Abstract Pulmonary sclerosing pneumocytoma (PSP) is a rare benign neoplasm that predominantly affects middle-aged Asian women. PSP is often asymptomatic and demonstrates a solitary pulmonary nodule on radiologic examination. We report a case of PSP initially misdiagnosed as lung cancer because of strong (18)F-fluorodeoxyglucose (FD... περισσότερα »
Renal metastasis from papillary carcinoma thyroid detected by whole body iodine scan: A case report and review of the literature.
*Renal metastasis from papillary carcinoma thyroid detected by whole body iodine scan: A case report and review of the literature.* Indian J Nucl Med. 2016 Jul-Sep;31(3):232-234 Authors: Nair LM, Anila KR, Sreekumar A, Pradeep VM Abstract Papillary carcinoma is the most common thyroid malignancy. Usual sites of metastasis include lungs and bone, but renal metastasis is very rare. Here we present a case of a follicular variant of papillary carcinoma with renal and lung metastasis at presentation. PMID: 27385900 [PubMed - as supplied by publisher] from pubmed: thyroid cancer http:... περισσότερα »
Metastasis in urothelial carcinoma mimicking prostate cancer metastasis in Ga-68 prostate-specific membrane antigen positron emission tomography-computed tomography in a case of synchronous malignancy.
*Metastasis in urothelial carcinoma mimicking prostate cancer metastasis in Ga-68 prostate-specific membrane antigen positron emission tomography-computed tomography in a case of synchronous malignancy.* Indian J Nucl Med. 2016 Jul-Sep;31(3):222-224 Authors: Gupta M, Choudhury PS, Gupta G, Gandhi J Abstract Prostate cancer is the second most common cancer in man. It commonly presents with urinary symptoms, bone pain, or diagnosed with elevated prostate-specific antigen.(PSA) levels. Correct staging and early diagnosis of recurrence by a precise imaging tool are the keys for optimu... περισσότερα »
A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis.
*A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis.* Indian J Nucl Med. 2016 Jul-Sep;31(3):210-214 Authors: Kunawudhi A, Promteangtrong C, Chotipanich C Abstract Thyroid cancer is usually, relatively hypofunctional; most patients with thyroid cancer are clinically euthyroid. The combination of thyroid cancer and thyrotoxicosis is not common. We herein, report a case of follicular thyroid cancer with hyperfunctioning metastasis in a 43-year-old woman who presented with thyrotoxicosis, a cold right thyroid nodule, and low I-131 uptake ... περισσότερα »
Impact of sweating on equivalent dose of patients treated with (131)Iiodine.
*Impact of sweating on equivalent dose of patients treated with (131)Iiodine.* Indian J Nucl Med. 2016 Jul-Sep;31(3):172-175 Authors: Haghighatafshar M, Banani A, Gheisari F, Alikhani M Abstract BACKGROUND: Radioiodine therapy is used for the treatment of patients with differentiated thyroid cancer (DTC) who undergo total thyroidectomy. After radioiodine administration, regulations require to quarantine these patients until their retained activity reduces to <33 mCi. Some of the injected radioiodine is excreted by perspiration which helps dose reduction so that performing the act... περισσότερα »
Bilateral vagal automatic periodic stimulation in single-incision transaxillary robotic total thyroidectomy.
*Bilateral vagal automatic periodic stimulation in single-incision transaxillary robotic total thyroidectomy.* Clin Otolaryngol. 2016 Jul 6; Authors: Aïdan P, Chung WY, Lörincz BB Abstract Automatic periodic stimulation (APS) of the vagus nerve during thyroid surgery may provide the patient with increased safety to prevent impending thermal or stretch-related injury to the recurrent laryngeal nerve (RLN). APS is of particular interest in remote access robotic thyroid surgery, where the RLN may be exposed to significant conducted heat due to the exclusive use of the ultrasonic ene... περισσότερα »
Post-Chernobyl incidence of papillary thyroid cancer among Belgian children less than 15 years of age in April 1986: a 30-year surgical experience.
*Post-Chernobyl incidence of papillary thyroid cancer among Belgian children less than 15 years of age in April 1986: a 30-year surgical experience.* Acta Chir Belg. 2016 Apr;116(2):101-113 Authors: Michel LA, Donckier J, Rosière A, Fervaille C, Lemaire J, Bertrand C Abstract OBJECTIVE: We raised the question of a possible relationship in Belgium between the occurrence of papillary thyroid carcinoma (PTC) and age of children (<15 years) at the time of the Chernobyl nuclear plant accident in April 1986. SETTING: Referral university centre for endocrine surgery. MATERIAL AND METHOD... περισσότερα »
Auricular epithesis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Level of Evidence NA Laryngoscope, 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29FG3N0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
In response to “hyoid surgery alone for obstructive sleep apnea: A systematic review and meta-analysis”
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29z1A7f via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Intraoperative electrophysiologic monitoring of the recurrent laryngeal nerve during thyroid and parathyroid surgery: Experience with 1,381 nerves at risk
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objectives The electrophysiologic responses of 1,381 recurrent laryngeal nerves (RLN) during monitored neck surgery were recorded and reviewed. Study Design Retrospective case series. Methods With institutional review board approval, we reviewed thyroid and other neck surgeries performed with intraoperative nerve monitoring (IONM) between the years 1995 and 2006. This list yielded consecutively monitored 1,381 RLNs, […]
The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.
*The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.* Nucl Med Commun. 2016 Jul 4; Authors: Stangierski A, Kaznowski J, Wolinski K, Jodlowska E, Michaliszyn P, Kubiak K, Czepczynski R, Ruchala M Abstract INTRODUCTION: PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) des... περισσότερα »
An Epidemiologic Study on Ageing and Dysphagia in the Acute Care Geriatric-Hospitalized Population: A Replication and Continuation Study.
*An Epidemiologic Study on Ageing and Dysphagia in the Acute Care Geriatric-Hospitalized Population: A Replication and Continuation Study.* Dysphagia. 2016 Jul 6; Authors: Leder SB, Suiter DM, Agogo GO, Cooney LM Abstract United States census data project dramatic increases in the geriatric population ageing demographics by 2060 with concomitant health-care consequences. The purpose of this replication and continuation study was to collect new 2014 demographic data relative to ageing, swallow evaluation referral rates, and oral feeding status in geriatric-hospitalized patients fo... περισσότερα »
Outcome of Rehabilitation and Swallowing Therapy After Percutaneous Endoscopic Gastrostomy in Dysphagia Patients.
*Outcome of Rehabilitation and Swallowing Therapy After Percutaneous Endoscopic Gastrostomy in Dysphagia Patients.* Dysphagia. 2016 Jul 6; Authors: Toh Yoon EW, Hirao J, Minoda N Abstract The objective of this study was to investigate the outcomes of rehabilitation (with swallowing therapy) after percutaneous endoscopic gastrostomy (PEG) in patients with neurogenic dysphagia. Forty-seven patients (29 males and 18 females) who were transferred to the rehabilitation ward of our hospital after receiving PEG tube placements during a 5-year period were enrolled in this study. Patients... περισσότερα »
Indomethacin-guided cancer selective prodrug system activated by histone deacetylase and tumour-associated protease
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC04255D, Communication Joo Hee Jang, Hoyeon Lee, Amit Sharma, Sang Min Lee, Tae Hoon Lee, Chulhun Kang, Jong Seung Kim An indomethacin guided drug delivery system (IGDDS) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consective demasking ventures for drug activation. IGDDS exhibited preferential uptake... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29qti4p via IFTTT
Beneficial Effects of Enteral Docosahexaenoic Acid on the Markers of Inflammation and Clinical Outcomes of Neonates Undergoing Cardiovascular Surgery: An Intervention Study
Background: Neonates undergoing surgery are at risk for uncontrolled inflammatory response and adverse clinical outcomes. Docosahexaenoic acid (DHA) ameliorates inflammation, improving clinical outcomes. However, its effect has not been evaluated in neonates undergoing surgery. We evaluated the effect of DHA on markers of inflammation and clinical outcomes in neonates undergoing surgery. Methods: A double-blind clinical… Continue reading Beneficial Effects of Enteral Docosahexaenoic Acid on the Markers of Inflammation and Clinical Outcomes of Neonates Undergoing Cardiovascular Surge... περισσότερα »
Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development
Abstract Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical for developing novel chemoprevention and targeted therapies. C-Jun N-terminal kinase (JNK) is a member of a larger group of serine/threonine (Ser/Thr) protein kinases known as the… Continue reading Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development
Bilateral Sequential Dacryocystitis in a Patient With Graft-Versus-Host Disease
A 29-year-old woman with a history of 2 bone marrow transplants for acute myelogenous leukemia developed bilateral sequential dacryocystitis in the context of known ocular graft-versus-host disease. With each infection, the patient underwent uneventful dacryocystorhinostomy. Postoperatively, she developed severe dry eye disease requiring replacement of punctal plugs and use of a prosthetic replacement of the… Continue reading Bilateral Sequential Dacryocystitis in a Patient With Graft-Versus-Host Disease
Aesthetic Abstracts and Citations
No abstract available from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29m71Jc via IFTTT
Key Issues When Reconstructing Extensive Upper Eyelid Defects With Description of a Dynamic, Frontalis Turnover Flap
Reconstruction of full thickness, total upper eyelid defects represents a significant challenge in terms of recreating an upper eyelid which has acceptable cosmesis and a degree of dynamic function. Options include bridging, eyelid-sharing techniques (e.g., Cutler-Beard), or nonbridging techniques such as an anterior lamella-based flap combined with a posterior lamella free graft or a “sandwich… Continue reading Key Issues When Reconstructing Extensive Upper Eyelid Defects With Description of a Dynamic, Frontalis Turnover Flap
“Histopathology and Immunophenotyping of Congenital Lacrimal (Anlage) Fistulae”
No abstract available from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29n5AGv via IFTTT
Electron Microscopic Features of Intraluminal Portion of Nasolacrimal Silastic Stents Following Dacryocystorhinostomy: Is There a Need for Stents Without a Lumen?
Aim: The aim of this study was to examine the presence of biofilms and physical deposits within the lumen of silastic nasolacrimal duct stents inserted during dacryocystorhinostomy. Methods: A prospective interventional study was performed on consecutive patients undergoing endoscopic dacryocystorhinostomy with Crawford stent insertion. All the patient samples were retrieved 4 weeks after the surgery.… Continue reading Electron Microscopic Features of Intraluminal Portion of Nasolacrimal Silastic Stents Following Dacryocystorhinostomy: Is There a Need for Stents Without a Lumen?
Granulicatella elegans Causing Periorbital Infection During Orthodontic Treatment
Granulicatella elegans is a normal component of the oral flora and is an unusual causative agent of infective endocarditis. A case of G. elegans periorbital infection of the eyelid after dental treatment is reported. A healthy 35-year-old man presented with painful swelling of the left upper eyelid. He was empirically treated with oral amoxicillin for… Continue reading Granulicatella elegans Causing Periorbital Infection During Orthodontic Treatment
Mullers Muscle Conjunctival Resection for Treatment of Contact Lens-Associated Ptosis
Purpose: The aim of this study was to look at the surgical outcomes of posterior approach Mullers muscle conjunctival resection surgery for contact lens-related ptosis. Methods: This was a retrospective, comparative interventional case series. All patients and controls underwent phenylephrine 10% testing and had a positive response prior to surgical intervention. Results: Thirty-one eyelids with… Continue reading Mullers Muscle Conjunctival Resection for Treatment of Contact Lens-Associated Ptosis
Ocular Trauma: Automatic Nail Gun
No abstract available from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29n5D5n via IFTTT
A qualitative investigation of decision making during help-seeking for adult hearing loss.
*A qualitative investigation of decision making during help-seeking for adult hearing loss.* Int J Audiol. 2016 Jul 6;:1-9 Authors: Pryce H, Hall A, Laplante-Lévesque A, Clark E Abstract OBJECTIVE: The Any Qualified Provider framework in the National Health Service has changed the way adult audiology services are offered in England. Under the new rules, patients are being offered a choice in geographical location and audiology provider. This study aimed to explore how choices in treatment are presented and to identify what information patients need when they are seeking help with... περισσότερα »
Perceived Odor-Taste Congruence Influences Intensity and Pleasantness Differently.
*Perceived Odor-Taste Congruence Influences Intensity and Pleasantness Differently.* Chem Senses. 2016 Jul 6; Authors: Amsellem S, Ohla K Abstract The role of congruence in cross-modal interactions has received little attention. In most experiments involving cross-modal pairs, congruence is conceived of as a binary process according to which cross-modal pairs are categorized as perceptually and/or semantically matching or mismatching. The present study investigated whether odor-taste congruence can be perceived gradually and whether congruence impacts other facets of subjective ... περισσότερα »
The Diagnostic Yield of Commonly Used Investigations in Pelvic Gunshot Wounds.
Background: Patients who sustain pelvic gunshot wounds (GSWs) are at significant risk for injury due to the density of pelvic structures. Currently, the optimal work-up for pelvic GSWs is unclear. The aim of this study was to determine the diagnostic yield of tests commonly used in the investigation of pelvic GSWs and to develop a diagnostic algorithm. Methods: All patients >=15 years old presenting to LAC+USC Medical Center (01/2008-02/2015) who sustained >=1 pelvic GSW were retrospectively identified. Patient demographics, clinical assessment, investigations, procedures, and outco... περισσότερα »
Stress among surgical attendings and trainees: A quantitative assessment during trauma activation and emergency surgeries.
BACKGROUND: The adverse effects of stress on the wellness of trauma team members is well established, however, the level of stress has never been quantitatively assessed. The aim of our study was to assess the level of stress using subjective data and objective heart rate variability (HRV) among attending surgeons (AS), junior (JR) (PGY2/PGY3), and senior (SR) (PGY5/PGY6) residents during trauma activation and emergency surgery. METHODS: We preformed a prospective study enrolling participants over eight 24-hour calls in our Level-1 trauma center. Stress was assessed based on decreas... περισσότερα »
Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.
Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling.: Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling. Oncotarget. 2016 Jul 1; Authors: McEntee G, Kyula JN, Mansfield D, Smith H, Wilkinson M, Gregory C, Roulstone V, Coffey M, Harrington KJ Abstract Oncolytic viruses selectively target and replicate in cancer cells, providing us with a unique tool with which to target and ... περισσότερα »
TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.
TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.: TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration. Oncotarget. 2016 Jul 1; Authors: Schwartz AL, Dickerson E, Dagia N, Malgor R, McCall KD Abstract Heightened co-expression and dysregulated signaling associated with Toll-like receptor 3 (TLR3) and Wnt5a is an integral component of solid tumors and hematological malignancies. Our previous findings in pancreatic cancer a... περισσότερα »
Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.
Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment.: Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment. Oncotarget. 2016 Jul 1; Authors: Hooren LV, Georganaki M, Huang H, Mangsbo SM, Dimberg A Abstract CD40-activating immunotherapy has potent antitumor effects due to its ability to activate dendritic cells and induce cytotoxic T-cell responses. However, its... περισσότερα »
Perceived Odor-Taste Congruence Influences Intensity and Pleasantness Differently.
*Perceived Odor-Taste Congruence Influences Intensity and Pleasantness Differently.* Chem Senses. 2016 Jul 6; Authors: Amsellem S, Ohla K Abstract The role of congruence in cross-modal interactions has received little attention. In most experiments involving cross-modal pairs, congruence is conceived of as a binary process according to which cross-modal pairs are categorized as perceptually and/or semantically matching or mismatching. The present study investigated whether odor-taste congruence can be perceived gradually and whether congruence impacts other facets of subjective ... περισσότερα »
Dose–volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study
[image: S01678140.gif] Publication date: Available online 7 July 2016 *Source:*Radiotherapy and Oncology Author(s): Renaud Mazeron, Lars U. Fokdal, Kathrin Kirchheiner, Petra Georg, Noha Jastaniyah, Barbara Šegedin, Umesh Mahantshetty, Peter Hoskin, Ina Jürgenliemk-Schulz, Christian Kirisists, Jacob C. Lindegaard, Wolfgang Dörr, Christine Haie-Meder, Kari Tanderup, Richard Pötter PurposeTo establish dose volume–effect relationships predicting late rectal morbidity in cervix cancer patients treated with concomitant chemoradiation and MRI-guided adaptive brachytherapy (IBABT) within th... περισσότερα »
Evolution of Disc Edema in Thyroid-Related Compressive Optic Neuropathy
[image: image]No abstract available from thyroid via a.lsfakia on Inoreader http://ift.tt/29rk0un via IFTTT
Intraoperative electrophysiologic monitoring of the recurrent laryngeal nerve during thyroid and parathyroid surgery: Experience with 1,381 nerves at risk
Objectives The electrophysiologic responses of 1,381 recurrent laryngeal nerves (RLN) during monitored neck surgery were recorded and reviewed. Study Design Retrospective case series. Methods With institutional review board approval, we reviewed thyroid and other neck surgeries performed with intraoperative nerve monitoring (IONM) between the years 1995 and 2006. This list yielded consecutively monitored 1,381 RLNs, with over 3,000 hours of monitoring experience. All patients underwent preoperative and postoperative laryngoscopy. In an initial subset of patients, both hook-wire... περισσότερα »
Clinicopathological Features of Low-Grade Thyroid-Like Nasopharyngeal Papillary Adenocarcinoma.
*Clinicopathological Features of Low-Grade Thyroid-Like Nasopharyngeal Papillary Adenocarcinoma.* Cancer Res Treat. 2016 Jul 4; Authors: Li M, Wei J, Yao X, Wang C Abstract Purpose: Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary ade... περισσότερα »
Thyroid Hormone Status in Umbilical Cord Serum is Positively Associated with Male Anogenital Distance.
*Thyroid Hormone Status in Umbilical Cord Serum is Positively Associated with Male Anogenital Distance.* J Clin Endocrinol Metab. 2016 Jul 6;:jc20153872 Authors: Liu R, Xu X, Zhang Y, Zheng X, Kim SS, Dietrich KN, Ho SM, Reponen T, Chen A, Huo X Abstract CONTEXT: In human adults and adolescents, thyroid function affects sex hormones and male reproductive functions. Little is known about the thyroid function effects on the gonadal development in human infants. OBJECTIVE: The aim was to examine the association between thyroid hormones (THs) and sexually dimorphic genital development... περισσότερα »
The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.
*The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.* Nucl Med Commun. 2016 Jul 4; Authors: Stangierski A, Kaznowski J, Wolinski K, Jodlowska E, Michaliszyn P, Kubiak K, Czepczynski R, Ruchala M Abstract INTRODUCTION: PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) des... περισσότερα »
Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer.
*Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer.* World J Surg. 2016 Jul 6; Authors: Hsu YC, Liu CL, Yang PS, Tsai CH, Lee JJ, Cheng SP Abstract BACKGROUND: Age is an important prognostic factor for papillary thyroid cancer (PTC). However, little is known about why advanced age is associated with poor prognosis. The study investigated the changes in transcriptional profiling related to age. METHODS: RNA sequencing data of PTC samples were retrieved from The Cancer Genome Atlas data portal. Spearman's correlation was used to test the ass... περισσότερα »
Thyroid hormone synthesis: a potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter.
*Thyroid hormone synthesis: a potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter.* Oncotarget. 2016 Jun 30; Authors: Zhang Y, Li Y, Mao X, Yan C, Guo X, Guo Q, Liu Z, Song Z, Lin N Abstract Haizao Yuhu Decoction (HYD), a famous multi-component herbal formula, has been widely used to treat various thyroid-related diseases, including iodine-deficient goiter. Herb pair Thallus Sargassi Pallidi (HZ) and Radix Glycyrrhizae (GC), one of the so-called "eighteen antagonistic medicaments", contains in HYD. To explore pharmacological mechani... περισσότερα »
ß-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation.
*ß-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation.* Oncotarget. 2016 Jun 30; Authors: Sastre-Perona A, Riesco-Eizaguirre G, Zaballos MA, Santisteban P Abstract Mutations in ß-catenin are traditionally described as late events in thyroid cancer progression. However, the functional implications of ß-catenin dysregulation in the context of tumor initiating events remain unclear. The aim of this work was to investigate whether the two main oncogenic drivers in thyroid cancer, RAS and BRAF, could activate the Wnt/ß-catenin pathway. Expression of HR... περισσότερα »
Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.
*Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.* Oncotarget. 2016 Jun 30; Authors: Jin X, Wang S, Zhao X, Jin Q, Fan C, Li J, Shan Z, Teng W Abstract Coumestrol is a common phytoestrogen found in plants and Chinese medicinal herbs. Its influences on experimental autoimmune thyroiditis (EAT) were investigated in this study. Female adult CBA/J mice were fed with drinking water containing 1% Tween80 only (Control group), 0.8 mg/l (L group) and 8 mg/l coumestrol (H group) from 6 to 15 weeks of age, respectively. Thei... περισσότερα »
Expression of CDX2 in gastriccardia adenocarcinoma and its correlation with H. pylori and cell proliferation.
*Expression of CDX2 in gastriccardia adenocarcinoma and its correlation with H. pylori and cell proliferation.* Oncotarget. 2016 Jul 1; Authors: Zhang Y, Wang H, Bi C, Xiao Y, Liu Z Abstract BACKGROUND: Gastric cardia cancer (GCC) is located in the distal stomach, and strongly correlates with atrophic gastritis and Helicobacter pylori(H.pylori) infection. Caudal-related homeobox transcription factor 2 (CDX2) is homeobox gene encoding an intestine-specific transcription factor usually expressed in the intestinal epithelium cells. However, in several recent published papers, CDX2 w... περισσότερα »
A meta-analysis of alcohol consumption and thyroid cancer risk.
*A meta-analysis of alcohol consumption and thyroid cancer risk.* Oncotarget. 2016 Jun 30; Authors: Wang X, Cheng W, Li J, Zhu J Abstract BACKGROUND: It is still inconclusive whether alcohol consumption affects the risk of thyroid cancer. We conducted a meta-analysis of available epidemiological data to address this issue. RESULTS: Compared with nondrinkers, the pooled relative risks (RRs) and corresponding 95% confidential intervals (CIs) of thyroid cancer were 0.80 (95% CI 0.71-0.90) for any drinkers, 0.81 (95% CI 0.70-0.93) for light and 0.71 (95% CI 0.63-0.79) for moderate dri... περισσότερα »
Atypia of Undetermined Significance on Thyroid Fine Needle Aspiration - Risk Factors for Malignancy.
*Atypia of Undetermined Significance on Thyroid Fine Needle Aspiration - Risk Factors for Malignancy.* Clin Otolaryngol. 2016 Jul 6; Authors: Seo JW, Jang AL, Suh SH, Park HS, Kang MK, Hong JC Abstract OBJECTIVES: This study is designed to determine the clinical predictors of malignancy in the atypia of undetermined significance (AUS) category resulted from thyroid fine needle aspiration (FNA). DESIGN: Retrospective cohort study. SETTING: Dong-A University Medical Center, Busan, Korea. PARTICIPANTS: Sixty-two patients who underwent thyroid surgery from January 2010 to December 2013... περισσότερα »
The rising incidence of papillary thyroid microcarcinoma and is completion surgery necessary or not?
*The rising incidence of papillary thyroid microcarcinoma and is completion surgery necessary or not?* Otolaryngol Pol. 2016;70(0):14-18 Authors: Kuşcu O, Önay Ö, Kayahan B, Süslü N, Yılmaz T Abstract Papillary thyroid microcarcinoma (PTMC) is defined as a papillary cancer that is 1 cm or less in its maximal diameter. The incidence of thyroid cancer has increased during the past 30 years. The aim of this study is to evaluate the rising incidence of PTMC (papillary thyroid microcarcinoma) and whether is lobectomy enough or not. The data of 462 consecutive patients who underwent th... περισσότερα »
A meta-analysis of alcohol consumption and thyroid cancer risk.
*A meta-analysis of alcohol consumption and thyroid cancer risk.* Oncotarget. 2016 Jun 30; Authors: Wang X, Cheng W, Li J, Zhu J Abstract BACKGROUND: It is still inconclusive whether alcohol consumption affects the risk of thyroid cancer. We conducted a meta-analysis of available epidemiological data to address this issue. RESULTS: Compared with nondrinkers, the pooled relative risks (RRs) and corresponding 95% confidential intervals (CIs) of thyroid cancer were 0.80 (95% CI 0.71-0.90) for any drinkers, 0.81 (95% CI 0.70-0.93) for light and 0.71 (95% CI 0.63-0.79) for moderate dri... περισσότερα »
Bilateral vagal automatic periodic stimulation in single-incision transaxillary robotic total thyroidectomy.
*Bilateral vagal automatic periodic stimulation in single-incision transaxillary robotic total thyroidectomy.* Clin Otolaryngol. 2016 Jul 6; Authors: Aïdan P, Chung WY, Lörincz BB Abstract Automatic periodic stimulation (APS) of the vagus nerve during thyroid surgery may provide the patient with increased safety to prevent impending thermal or stretch-related injury to the recurrent laryngeal nerve (RLN). APS is of particular interest in remote access robotic thyroid surgery, where the RLN may be exposed to significant conducted heat due to the exclusive use of the ultrasonic ene... περισσότερα »
Fine needle aspiration cytology guided by ultrasound in the diagnosis of subcentimetre thyroid nodules.
*Fine needle aspiration cytology guided by ultrasound in the diagnosis of subcentimetre thyroid nodules.* Springerplus. 2016;5(1):876 Authors: Li C, Zhan W, Yi F, Zheng B, Zhou Y, Zhao R, Jia Y Abstract BACKGROUND: This study aimed to investigate the value of fine needle aspiration biopsy (FNAB) under ultrasound guidance in diagnosis of thyroid nodules. In a retrospective analysis of FNAB in 1050 cases of patients with 1100 nodules, patients were divided according to the maximum diameter of their nodules into two groups: >1.0 and ≤1.0 cm. The ultrasound-guided FNAB cytology resul... περισσότερα »
Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature.
*Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature.* Thorac Cancer. 2016 Jul;7(4):508-511 Authors: Lim JH, Lee N, Choi DW, Oh HJ, Park HY, Kim KH, Kim TO, Park CK, Shin HJ, Choi YD, Yun JS, Song SY, Oh IJ Abstract Pulmonary sclerosing pneumocytoma (PSP) is a rare benign neoplasm that predominantly affects middle-aged Asian women. PSP is often asymptomatic and demonstrates a solitary pulmonary nodule on radiologic examination. We report a case of PSP initially misdiagnosed as lung cancer because of strong (18)F-fluorodeoxyglucose (FD... περισσότερα »
Renal metastasis from papillary carcinoma thyroid detected by whole body iodine scan: A case report and review of the literature.
*Renal metastasis from papillary carcinoma thyroid detected by whole body iodine scan: A case report and review of the literature.* Indian J Nucl Med. 2016 Jul-Sep;31(3):232-234 Authors: Nair LM, Anila KR, Sreekumar A, Pradeep VM Abstract Papillary carcinoma is the most common thyroid malignancy. Usual sites of metastasis include lungs and bone, but renal metastasis is very rare. Here we present a case of a follicular variant of papillary carcinoma with renal and lung metastasis at presentation. PMID: 27385900 [PubMed - as supplied by publisher] http://ift.tt/29BgQUm
Metastasis in urothelial carcinoma mimicking prostate cancer metastasis in Ga-68 prostate-specific membrane antigen positron emission tomography-computed tomography in a case of synchronous malignancy.
*Metastasis in urothelial carcinoma mimicking prostate cancer metastasis in Ga-68 prostate-specific membrane antigen positron emission tomography-computed tomography in a case of synchronous malignancy.* Indian J Nucl Med. 2016 Jul-Sep;31(3):222-224 Authors: Gupta M, Choudhury PS, Gupta G, Gandhi J Abstract Prostate cancer is the second most common cancer in man. It commonly presents with urinary symptoms, bone pain, or diagnosed with elevated prostate-specific antigen.(PSA) levels. Correct staging and early diagnosis of recurrence by a precise imaging tool are the keys for optimu... περισσότερα »
A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis.
*A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis.* Indian J Nucl Med. 2016 Jul-Sep;31(3):210-214 Authors: Kunawudhi A, Promteangtrong C, Chotipanich C Abstract Thyroid cancer is usually, relatively hypofunctional; most patients with thyroid cancer are clinically euthyroid. The combination of thyroid cancer and thyrotoxicosis is not common. We herein, report a case of follicular thyroid cancer with hyperfunctioning metastasis in a 43-year-old woman who presented with thyrotoxicosis, a cold right thyroid nodule, and low I-131 uptake ... περισσότερα »
Impact of sweating on equivalent dose of patients treated with (131)Iiodine.
*Impact of sweating on equivalent dose of patients treated with (131)Iiodine.* Indian J Nucl Med. 2016 Jul-Sep;31(3):172-175 Authors: Haghighatafshar M, Banani A, Gheisari F, Alikhani M Abstract BACKGROUND: Radioiodine therapy is used for the treatment of patients with differentiated thyroid cancer (DTC) who undergo total thyroidectomy. After radioiodine administration, regulations require to quarantine these patients until their retained activity reduces to <33 mCi. Some of the injected radioiodine is excreted by perspiration which helps dose reduction so that performing the act... περισσότερα »
Bilateral vagal automatic periodic stimulation in single-incision transaxillary robotic total thyroidectomy.
*Bilateral vagal automatic periodic stimulation in single-incision transaxillary robotic total thyroidectomy.* Clin Otolaryngol. 2016 Jul 6; Authors: Aïdan P, Chung WY, Lörincz BB Abstract Automatic periodic stimulation (APS) of the vagus nerve during thyroid surgery may provide the patient with increased safety to prevent impending thermal or stretch-related injury to the recurrent laryngeal nerve (RLN). APS is of particular interest in remote access robotic thyroid surgery, where the RLN may be exposed to significant conducted heat due to the exclusive use of the ultrasonic ene... περισσότερα »
Post-Chernobyl incidence of papillary thyroid cancer among Belgian children less than 15 years of age in April 1986: a 30-year surgical experience.
*Post-Chernobyl incidence of papillary thyroid cancer among Belgian children less than 15 years of age in April 1986: a 30-year surgical experience.* Acta Chir Belg. 2016 Apr;116(2):101-113 Authors: Michel LA, Donckier J, Rosière A, Fervaille C, Lemaire J, Bertrand C Abstract OBJECTIVE: We raised the question of a possible relationship in Belgium between the occurrence of papillary thyroid carcinoma (PTC) and age of children (<15 years) at the time of the Chernobyl nuclear plant accident in April 1986. SETTING: Referral university centre for endocrine surgery. MATERIAL AND METHOD... περισσότερα »
Malignancy risk of oncocytic changes in thyroid nodules: who should we offer surgery to?
*Malignancy risk of oncocytic changes in thyroid nodules: who should we offer surgery to?* Acta Chir Belg. 2016 Feb;116(1):30-35 Authors: Yazici P, Yilmaz B, Bozkurt E, Mihmanli M, Uludag M Abstract Background Oncocytic (Hürthle) cell in fine-needle aspiration biopsy (FNAB) remains challenging for surgeons. Surgical treatment is recommended for oncocytic change in FNAB, since it can sometimes be a struggle to determine the nature of thyroid nodules. We aimed to investigate the clinical significance of oncocytic changes in FNAB in terms of management of patients. Methods The FNAB ... περισσότερα »
A meta-analysis of alcohol consumption and thyroid cancer risk.
*A meta-analysis of alcohol consumption and thyroid cancer risk.* Oncotarget. 2016 Jun 30; Authors: Wang X, Cheng W, Li J, Zhu J Abstract BACKGROUND: It is still inconclusive whether alcohol consumption affects the risk of thyroid cancer. We conducted a meta-analysis of available epidemiological data to address this issue. RESULTS: Compared with nondrinkers, the pooled relative risks (RRs) and corresponding 95% confidential intervals (CIs) of thyroid cancer were 0.80 (95% CI 0.71-0.90) for any drinkers, 0.81 (95% CI 0.70-0.93) for light and 0.71 (95% CI 0.63-0.79) for moderate dri... περισσότερα »
Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study.
*Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study.* Caspian J Intern Med. 2016;7(2):93-98 Authors: Sheikhzadeh M, Lotfi Y, Mousavi A, Heidari B, Monadi M, Bakhshi E Abstract BACKGROUND: Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency. This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV. METHODS: The study population was selected consecutively and the diagnosis of BPPV was made by history and clinical examination and exclusion of oth... περισσότερα »
A Novel Frameshift Mutation of SLC26A4 in a Korean Family With Nonsyndromic Hearing Loss and Enlarged Vestibular Aqueduct.
*A Novel Frameshift Mutation of SLC26A4 in a Korean Family With Nonsyndromic Hearing Loss and Enlarged Vestibular Aqueduct.* Clin Exp Otorhinolaryngol. 2016 Jul 7; Authors: Sagong B, Baek JI, Lee KY, Kim UK Abstract Objectives: We aimed to identify the causative mutation for siblings in a Korean family with nonsyndromic hearing loss (HL) and enlarged vestibular aqueduct (EVA). The siblings were a 19-year-old female with bilateral profound HL and an 11-year-old male with bilateral moderately severe HL. Methods: We extracted genomic DNA from blood samples of the siblings with HL, th... περισσότερα »
SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans.
*SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans.* J Hum Genet. 2016 Jul 7; Authors: Guan J, Wang D, Cao W, Zhao Y, Du R, Yuan H, Liu Q, Lan L, Zong L, Yang J, Yin Z, Han B, Zhang F, Wang Q Abstract The ossicles represent one of the most fundamental morphological features in evolutionary biology of the mammalians. The mobile ossicular morphology abnormalities result in the severe conductive hearing loss. Development and patterning of the middle ear malformation depend on genetic and environmental causes. However, the genetic basis for the risk of cong... περισσότερα »
Comparison of average global exposure of population induced by a macro 3G network in different geographical areas in France and Serbia.
*Comparison of average global exposure of population induced by a macro 3G network in different geographical areas in France and Serbia.* Bioelectromagnetics. 2016 Jul 6; Authors: Huang Y, Varsier N, Niksic S, Kocan E, Pejanovic-Djurisic M, Popovic M, Koprivica M, Neskovic A, Milinkovic J, Gati A, Person C, Wiart J Abstract This article is the first thorough study of average population exposure to third generation network (3G)-induced electromagnetic fields (EMFs), from both uplink and downlink radio emissions in different countries, geographical areas, and for different wireless ... περισσότερα »
An Epidemiologic Study on Ageing and Dysphagia in the Acute Care Geriatric-Hospitalized Population: A Replication and Continuation Study.
*An Epidemiologic Study on Ageing and Dysphagia in the Acute Care Geriatric-Hospitalized Population: A Replication and Continuation Study.* Dysphagia. 2016 Jul 6; Authors: Leder SB, Suiter DM, Agogo GO, Cooney LM Abstract United States census data project dramatic increases in the geriatric population ageing demographics by 2060 with concomitant health-care consequences. The purpose of this replication and continuation study was to collect new 2014 demographic data relative to ageing, swallow evaluation referral rates, and oral feeding status in geriatric-hospitalized patients fo... περισσότερα »
Psychological distress and community approach to the voice of the community health agent.
*Psychological distress and community approach to the voice of the community health agent.* Rev Esc Enferm USP. 2016 Jun;50(spe):139-144 Authors: Paiva PC, Torrenté MO, Landim FL, Branco JG, Tamboril BC, Cabral AL Abstract The user in psychological distress needs a service that provides a targeted assistance, that welcomes when required, acting as originator care device to the user on the network of health care. This study aimed to describe how people in psychological distress are perceived by the community in the voice of the community health worker. It is a qualitative research ... περισσότερα »
Let's call it "aphasia": Rationales for eliminating the term "dysphasia".
*Let's call it "aphasia": Rationales for eliminating the term "dysphasia".* Int J Stroke. 2016 Jul 6; Authors: Worrall L, Simmons-Mackie N, Wallace SJ, Rose T, Brady MC, Kong AP, Murray L, Hallowell B Abstract Health professionals, researchers, and policy makers often consider the two terms aphasia and dysphasia to be synonymous. The aim of this article is to argue the merits of the exclusive use of the term aphasia and present a strategy for creating change through institutions such as the WHO-ICD. Our contention is that one term avoids confusion, speech-language pathologists pr... περισσότερα »
Frugal innovation in medicine for low resource settings.
*Frugal innovation in medicine for low resource settings.* BMC Med. 2016;14(1):102 Authors: Tran VT, Ravaud P Abstract Whilst it is clear that technology is crucial to advance healthcare: innovation in medicine is not just about high-tech tools, new procedures or genome discoveries. In constrained environments, healthcare providers often create unexpected solutions to provide adequate healthcare to patients. These inexpensive but effective frugal innovations may be imperfect, but they have the power to ensure that health is within reach of everyone. Frugal innovations are not lim... περισσότερα »
Shielding voices: The modulation of binding processes between voice features and response features by task representations.
*Shielding voices: The modulation of binding processes between voice features and response features by task representations.* Q J Exp Psychol (Hove). 2016 Jul 6;:1-27 Authors: Bogon J, Eisenbarth H, Landgraf S, Dreisbach G Abstract During speech perception, we do not only process semantic-linguistic content but also information about the identity and the motivational and emotional state of the speaker. Furthermore, most vocal events have implications for our actions and therefore include action-related features. But the relevance and irrelevance of vocal features varies from task ... περισσότερα »
Self-assessment and readiness for change in dysphonic patients.
*Self-assessment and readiness for change in dysphonic patients.* Codas. 2016 Jul 4;0:0 Authors: Lopes LW, Vilela EG Abstract Purpose: To examine whether there is an association between vocal self-assessment and readiness for change in dysphonic patients. Methods: 151 patients with vocal complaints and diagnosis of dysphonia, between 18 and 65 years of age, 47 men and 104 women treated at the voice clinic of a public institution participated in the study. Four self-assessment instruments were applied, including the Voice-Related Quality of Life (V-RQOL), the Voice Handicap Index (... περισσότερα »
Native Transformations in the Pacific Northwest: A strength-based model of protection against substance use disorder.
*Native Transformations in the Pacific Northwest: A strength-based model of protection against substance use disorder.* Am Indian Alsk Native Ment Health Res. 2016;23(3):158-186 Authors: Rasmus S, Allen J, Connor W, Freeman W, Native Transformations Community Action Board, Skewes M Abstract This paper presents findings from the Native Transformations Project, an exploratory community-based participatory research study that aims to identify sources of strength and protection against substance use disorder in three tribal communities in the coastal Pacific Northwest. Preliminary re... περισσότερα »
[Cause and treatment of unilateral vocal cord paralysis].
*[Cause and treatment of unilateral vocal cord paralysis].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):423-6 Authors: Xu D, Li K Abstract Unilateral vocal cord paralysis(UVCP) is defined as affected side vocal cord emerges immobility or motion weakening and abnormal tension due to unilateral intrinsic laryngeal muscles suffering from disorder about motor nerve. The patients usually present with hoarse voice, disability of high pitch, cough, aspiration, or a combination of these symptoms. There are increasing therapeutics researches and case analyses regarding U... περισσότερα »
[A study on vowel duration and word length of adductor spasmodic dysphonia].
*[A study on vowel duration and word length of adductor spasmodic dysphonia].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):378-80 Authors: Chen Z, Ge P Abstract OBJECTIVE: To understand the vowel duration and statement reading of the adductor spasmodic dysphonia (ADSD) patients compared with their normal controls, and provide ideas for clinical diagnosis and treatment. METHOD: Twenty-nine ADSD patients were included in the research, with 31 normal controls. All subjects filled in form voice handicap index (VHI) by themselves. Maximum phonetic time (MPT) and maxi... περισσότερα »
[Moyamoya disease].
*[Moyamoya disease].* Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(4):74-8 Authors: Esin RG, Isayeva YN, Gorobets EA, Tokareva NV, Esin OR Abstract Moya-moya is a rare cerebrovascular disease characterized by the progressive occlusion of cerebral vessels with partial switching off the circle of Willis and arteries that feed it. The article provides a review of literature, modern diagnostic criteria and a description of a single clinical case. The onset of the disease in this patient was characterized by headache and speech disorders.An analysis of speech disorders showed that t... περισσότερα »
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