Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Publication date: 13 September 2016
Source:Cell Metabolism, Volume 24, Issue 3
Author(s): Harding H. Luan, Ruslan Medzhitov
Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.

Teaser

In this Minireview, Luan and Medzhitov discuss the newly discovered mammalian metabolite itaconate as both a regulator and effector of immunity. More generally, they explore the emerging concept that metabolites have distinct immunological functions that could be employed as antimicrobial therapeutics.


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