Is the association between exhaled nitric oxide and asthma symptoms altered by body weight in rural adolescents?

Some studies have found that increased levels of exhaled nitric oxide (eNO) correspond to more frequent asthma symptoms.1,2 However, recent studies in adult and adolescent patients have suggested that obese or overweight individuals with asthma have decreased eNO levels compared with their normal weight counterparts.3,4 If this decreased eNO hypothesis in obesity is correct, then the association between eNO and asthma symptoms is likely to vary by body mass index (BMI; calculated as the weight in kilograms divided by square of height in meters).

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