MYD88 mutations in a distinct type of cutaneous marginal zone lymphoma with a non-class switched IgM-immunophenotype

Somatic mutations in the MYD88 gene are involved in the molecular pathogenesis of different subtypes of Non-Hodgkin B-cell lymphomas such as diffuse large B-cell lymphoma, lymphoplasmacytic lymphoma and Waldenstrom′s macroglobulinemia¹. Albeit with much lower frequency, the key driver mutation MYD88 (c.794T>C, p.L265P) has also been identified in non-cutaneous marginal zone lymphomas and chronic lymphocytic leukemia. The increasing knowledge about such molecular aberrations and their consecutive biological effects has already been implemented within the clinical routine.

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