Tetracyclines and/ or Nicotinamide in blistering dermatoses

Abstract

I read with interest a report by von Köckritz et al¹. Tetracycline therapy, particularly in autoimmune blistering conditions, has become an acceptable treatment modality among elderly individuals, particularly those with osteoporosis, DM, and hypertension. This drug has also been given in combination with immunosuppressive treatment for more rapid tapering of the latter² .Minocycline besides having antimicrobial activity, it possesses anti-inflammatory and anti-apoptotic properties and causes inhibition of proteolysis, angiogenesis, and collagenase, and ability to induce read-through of premature stop mutations³. Nicotinamide is a potent modulator of several pro-inflammatory cytokines.

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