Fetuin-A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease

Abstract

Objectives

The present study is evaluating fetuin-A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.

Material and Methods

Sixty patients were divided into three groups: Group 1 periodontal health (n=20), group 2 gingivitis (n=20) and group 3 chronic periodontitis (CP) (n=20). GCF and serum samples were evaluated using enzyme linked immunosorbent assay kit.

Results

SAA and TNF-α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P<0.016). Contrarily, fetuin-A levels in GCF and serum were significantly higher in controls than in patients with gingivitis and CP (P<0.016). In CP group, a significant correlation was observed between GCF SAA amount and the number of sites with 4 ≤ PPD ≤ 5 mm (P < 0.05). There was a significant correlation between GCF fetuin-A levels and the number of sites with PPD ≥6 mm (P < 0.05). GCF TNF-α was found to have a significant relationship with the number of sites with 4≤PPD≤5 mm and PPD≥6 mm (P <0.05).

Conclusions

In conclusion, serum and total levels of SAA significantly increased, whereas Fetuin-A levels significantly decreased, with increasing severity of PD.

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