A patient with idiopathic angioedema presenting with superior vena cava syndrome and lymphedema

A 40-year-old woman with a history of 2 episodes of corticosteroid-responsive angioedema without urticaria presented to the allergy clinic for evaluation of recurrent angioedema after a third episode. Her medical history was significant for papillary thyroid carcinoma that required anterior neck dissection and radiation as well as epithelioid hemangioendothelioma of the right internal jugular vein that required resection and graft placement. Her first episode of laryngeal edema occurred while she was completing radiation treatment 10 months earlier and was accompanied by 1 day of shortness of breath and stridor that required admission to the intensive care unit.

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