Bluish nodules of the breast in an adolescent girl

Description

A 15-year-old girl was referred due to skin lesions of the right breast, which had first been noticed shortly after birth and had enlarged slowly with the patient's growth but more rapidly in the past few years. Family history disclosed that the patient's father had similar lesions on the left shoulder. Physical examination revealed multiple bluish coalescent soft nodules on the right breast, which were slightly tender to palpation (figure 1). Histological examination demonstrated dilated irregular vascular channels surrounded by endothelial cells and one to several layers of uniform cuboidal cells with a pale or faintly eosinophilic cytoplasm (figure 2). These features were consistent with the diagnosis of glomuvenous malformation (GVM).

Figure 1

Clinical presentation. Multiple well-defined bluish to purple coalescent soft and slightly tender nodules on the right breast.

Figure 2

Histopathological findings. Dilated capillaries containing...

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