Identification of drug- and drug-metabolite immune responses originating from both naïve and memory T-cells

Publication date: Available online 10 January 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Andrew Gibson, Lee Faulkner, Sally Wood, B. Kevin Park, Dean J. Naisbitt

Teaser

Summary: Both naïve and memory T-cells from drug-naive donors can be stimulated by parent drug and drug haptens. Thus, drug-derived antigens can stimulate naïve T-cells alongside pre-existing memory T-cells through proposed heterologous immunity with an as yet undetermined peptide antigen.


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