Next step: functional studies on hypertension, lichen planus and TRPA1 connections

Abstract

We would like to thank for the invaluable insights of Shan and colleagues (Shan et al, 2017). They put forward a most logical hypothesis for a link between Koebner phenomenon and the mechanoreceptor Transient Receptor Potential Ankyrin 1 (TRPA1). As suggested, TRPA1 expression in non-lesion mucosal areas of oral lichen planus (OLP) patients should also be investigated. Furthermore, buccal samples form people displaying mursicatio buccarum may be used to test if prolonged mechanical stimuli alone upregulate TRPA1 in the oral mucosa.

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