Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinico-pathological entity with better prognosis

Abstract

Background

The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC).

Methods

217 cases of OSCC were retrieved from achieves for the analysis.OSCC-OSMF cases were segregated on the basis of history and clinico-pathological parameters.

Results

The study included 217 patients of which 112 had OSCC and 105 OSCC-OSMF. OSCC-OSMFs were younger compared with OSCC. Overall oral cancer was noted predominantly in males compared to females. The number of OSCC-OSMF were more in TNM Stage I and Stage II as compared to OSCC, where as the number of OSCC were more in Stage III and Stage IV compared to OSCC-OSMF.Histological presentation of well differentiated Squamous cell carcinoma (WDSCC) was significantly more in OSCC-OSMF compared to OSCC, where as histological presentation of moderately differentiated squamous cell carcinoma was significantly more in OSCC compared to OSCC-OSMF. Regional lymph node metastasis was significantly higher in OSCC compared to OSCC-OSMF. Three year disease free survival rate was significantly higher in OSCC-OSMF compared to OSCC.

Conclusion

The OSCC-OSMF was found to be a clinicpathologically distinct entity compared to OSCCwith a better grade of tumor differentiation, less incidence of nodal metastases and early detection (early clinical TNM stage).All these factors probably contribute to a better prognosis and increased three yeardisease free survival.

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