Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Σάββατο 7 Ιανουαρίου 2017

Race is associated with differences in airway inflammation in patients with asthma

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Publication date: Available online 6 January 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Sharmilee M. Nyenhuis, Jerry A. Krishnan, Alalia Berry, William J. Calhoun, Vernon M. Chinchilli, Linda Engle, Nicole Grossman, Fernando Holguin, Elliot Israel, Rick A. Kittles, Monica Kraft, Stephen C. Lazarus, Erik B. Lehman, David T. Mauger, James N. Moy, Stephen P. Peters, Wanda Phipatanakul, Lewis J. Smith, Kaharu Sumino, Stanley J. Szefler, Michael E. Wechsler, Sally Wenzel, Steven R. White, Steven J. Ackerman
BackgroundAfrican American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear.ObjectiveWe sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS−, respectively).MethodsWe performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute–sponsored Asthma Clinical Research Network and AsthmaNet. Demographics, clinical characteristics, and sputum cytology after sputum induction were examined. We used a sputum eosinophil 2% cut point to define subjects with either an eosinophilic (≥2%) or noneosinophilic (<2%) inflammatory phenotype.ResultsAmong 1018 participants, African American subjects (n = 264) had a lower FEV1 percent predicted (80% vs 85%, P < .01), greater total IgE levels (197 vs 120 IU/mL, P < .01), and a greater proportion with uncontrolled asthma (43% vs 28%, P < .01) compared with white subjects (n = 754). There were 922 subjects in the ICS+ group (248 African American and 674 white subjects) and 298 subjects in the ICS− group (49 African American and 249 white subjects). Eosinophilic airway inflammation was not significantly different between African American and white subjects in either group (percentage with eosinophilic phenotype: ICS+ group: 19% vs 16%, P = .28; ICS− group: 39% vs 35%, P = .65; respectively). However, when adjusted for confounding factors, African American subjects were more likely to exhibit eosinophilic airway inflammation than white subjects in the ICS+ group (odds ratio, 1.58; 95% CI, 1.01-2.48; P = .046) but not in the ICS− group (P = .984).ConclusionAfrican American subjects exhibit greater eosinophilic airway inflammation, which might explain the greater asthma burden in this population.



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