A case of linear basal cell carcinoma: evaluation of proliferative activity by immunohistochemical staining of PCTAIRE1 and p27

Abstract

Linear basal cell carcinoma (LBCC) is a unique morphological variant of basal cell carcinoma (BCC)^1-3, and the mechanism behind the linear form has yet to be fully elucidated. To date, we have investigated the functions of p27 (Kip1) and PCTAIRE1 (also known as PCTK1, Cdk16) in tumorigenesis.^{4, 5} PCTAIRE1 is a member of the PCTAIRE family, which is related to the Cdk family, and it phosphorylates p27, leading to ubiquitination/degradation of this tumor suppressor.^{6, 7} An inverse correlation between p27 and PCTAIRE1 expressions has been observed in malignant tumors.

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