Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 15 Φεβρουαρίου 2017

Clinical markers of asthma and IgE assessed in parents before conception predicts asthma and hay fever in the offspring

Abstract

Background

Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.

Objective

We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs after birth, with offspring asthma and hay fever.

Methods

The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991-1993, and data on 9100 offspring born 1972-2012. Adjusted relative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.

Results

Offspring asthma with hay fever was more strongly associated with parental BHR and specific IgE measured before conception than after birth (BHR: aRRR=2.96 [95% CI: 1.92, 4.57] and 1.40[1.03, 1.91], respectively; specific IgEs: 3.08[2.13, 4.45] and 1.83[1.45, 2.31], respectively). This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11-22 years with information on parental disease activity both before and after birth.

Conclusion & Clinical Relevance

Parental BHR and specific IgE were associated with offspring asthma and hay fever, with the strongest associations observed with before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hay fever.

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