Differential morphological and functional features of fibroblasts explanted from Solar Lentigo

Upon ageing, chronic exposure to ultraviolet radiations and pollution induces benign hyper-pigmented lesions, such as Solar Lentigo maculae (SL) ¹. Well-defined histologically, SL is distinguishable from other hyper-pigmented diseases and can be classified relative to its evolution ^2-4. Differential gene-profiling analyses comparing SL and normal skin biopsies revealed that SL tissues are mainly composed of epidermal activated melanocytes as well as hypo-proliferating and hypo-differentiated keratinocytes with a background of chronic inflammation. In absence of fibroblast markers, immuno-staining analyses for several growth factors and secreted proteins in the upper dermis of SL biopsies strongly suggest that dermal fibroblasts contribute functionally to dysregulation of epidermal cells ⁵. These observations are strengthened by recent studies using a pigmented reconstructed skin model that demonstrates the influence of dermal fibroblasts on skin pigmentation ⁶. However, data on the morphological and functional features of the SL primary fibroblasts that could explain their role in SL disease are not available.

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