Source:Journal of Oral and Maxillofacial Surgery
Author(s): Massimo Del Fabbro, Cristina Bucchi, Alessandra Lolato, Stefano Corbella, Tiziano Testori, Silvio Taschieri
PurposeThe true benefit of autologous platelet concentrates (APCs) for enhancing the healing of post-extraction sites is still a matter of debate and in the last years, several clinical trials addressed this issue. The purpose of this study was to determine the effectiveness of APC adjunct in the preservation of fresh extraction sockets.Materials and MethodsAn electronic search was performed on MEDLINE, Embase, Scopus, and Cochrane Central Register of Controlled Trials. Only controlled clinical trials or randomized clinical trials were included. Selected articles underwent risk-of-bias assessment. The outcomes were: complications and adverse events, discomfort/quality of life, bone healing and remodelling assessed by histological and radiographic techniques, and soft tissue healing.ResultsThirty-three comparative studies were included. Nine articles had a parallel design and 24 had a split-mouth design. Twenty studies were considered at low risk of bias and 13 at high risk. 1193 teeth were extracted in 911 patients. Meta-analysis showed that soft tissue healing, probing depth at 3 months and bone density at 1, 3 and 6 month were statistically better for APC group. Qualitative analysis suggested that APCs may be associated with a reduction in swelling and trismus. However, no significant difference among groups was found regarding probing depth at 1 month, incidence of alveolar osteitis, acute inflammation or infection, percentage of new bone and indirect measurement of bone metabolism.ConclusionAPCs should be used in post-extraction sites in order to improve clinical and radiographic outcomes like bone density and soft tissue healing, as well as postoperative symptoms. The actual benefit of platelet concentrates on pain reduction in extraction sockets is still not quantifiable.
http://ift.tt/2lp4sbS
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου