Potential for Osseous Regeneration of Platelet Rich Fibrin - A Comparative Study In Mandibular Third Molar Impaction Sockets

Publication date: Available online 4 February 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Mathew P. Varghese, Suvy Manuel, L.K. Surej Kumar
PurposeOur study determined the potential for osseous regeneration of platelet rich fibrin (PRF) in mandibular third molar impaction sockets along with its soft tissue healing potential.Patients and MethodsWe designed the study to be carried out as a prospective in-vivo study. Following extraction, randomization was done. On one side, the socket was sutured primarily (control site) and on the other, autologous PRF gel, was placed and sutured (test site/PRF site). Post operatively, grid periapical radiographs were obtained, at periodic intervals (1st week, 4th week, 16th week) and digitalized. The grey level values were measured at 3 different regions of the socket (RNFB – Regions of Newly Formed Bone), compared with natural bone area (NBA); using HL Image++ software, and calculation of percentage bone fill was made. Clinical evaluation of soft tissue healing was done using Landry Turnbull & Howley index at the specific intervals.Results30 healthy subjects, both male & female (age 18 – 35 years) with bilaterally impacted mandibular third molars were enrolled in this study. It was found that, in general, there was significantly greater bone formation in sockets treated with PRF (P value < 0.05). In the PRF group, the average grey level values at cervical, middle and apical regions were 61.85 (SD ± 25.186), 64.54 (SD ± 24.831) & 67.80 (SD ± 23.946), respectively, with a mean value of 64.73 (SD ± 24.411). In the control group, these values were 51.58 (SD ± 15.286), 54.30 (SD ± 16.274) &57.53 (SD ±16.187) respectively with a mean of 53.67 (SD ± 16.528). The average percentage bone fill of PRF category patients was 57.90 (SD ± 26.789) and that of the non PRF patients, 46.74 (SD ± 17.713) (P<0.05). The soft tissue healing as evaluated by Landry Turnbull & Howley healing index also was found to be better on the (PRF) test site and it was statistically significant (P<0.05).ConclusionsThere was evidence for better osseous regeneration & soft tissue healing occurring in response to PRF. Further investigations to evaluate the application of PRF in other areas of oral and maxillofacial surgery is imperative.



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