Striae gravidarum leukaemia cutis: a rare manifestation of acute myeloid leukaemia

Description

A multiparous woman aged 33 years presented to the haematology clinic with an abdominal skin rash and an abnormal full blood count. Physical examination revealed violaceous discolouration and hypertrophy of the striae gravidarum (SG) (figure 1A, B), sparing the surrounding skin. The patient denied taking steroids.

Figure 1

(A and B) Striae gravidarum hypertrophy with violaceous discolouration.

At the time of presentation, her white cell count was 66 000/mm³, her haemoglobin level was 6.7 g/dL and her platelet count was 32 000/mm³. A blood film revealed monoblasts and the bone marrow biopsy showed hypercellular bone marrow due to infiltration by sheets of immature cells (monoblasts and promonocytes). The monoblasts were folded nuclei, with delicate chromatin and occasional vacuolated cytoplasm. The promonocytes were having less basophilic cytoplasm and occasionally granulated cytoplasm (figure 2). Flow cytometry analysis of a corresponding marrow sample revealed...

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