Abstract
Methotrexate is a folic acid derivative that inhibits dihydrofolate reductase which has effects on DNA synthesis and cellular replication. In Dermatology, it is licensed for use in recalcitrant psoriasis but is also used off-label in many other conditions.1
It is given either orally or by subcutaneous injection. Folic acid is usually prescribed alongside methotrexate but there is often variation in prescribing practice.
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