Immunohistochemical and Histochemical Characterization of Intraosseous Arteriovenous Malformations of the Jaws: Analysis of 16 Cases with Emphasis on GLUT-1 Immunophenotype

Publication date: Available online 25 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Reda Taleb, Ioannis G. Koutlas, Prokopios P. Argyris
ObjectivesIntraosseous vascular lesions of the craniofacial region are rare and may cause diagnostic and therapeutic dilemmas. The purpose of this study was to characterize 16 cases of intraosseous arteriovenous malformation (AVM) affecting the jaws.Study design: Immunohistochemical evaluation was performed using antibodies against α-SMA, desmin, CD31, D2-40 and GLUT-1. Elastic Verhoeff-Van Gieson and Masson trichrome histochemical stains were also performed.ResultsNo gender predilection (F:M ratio = 1:1) was observed with patients' mean age being 50.8 years (SD: ± 13.9, age range: 28-71 years). Prevalence for the mandible was observed (12/16, 75%). Immunohistochemically, diffuse endothelial CD31 staining was noted, while α-SMA strongly decorated smooth muscle cells and pericytes. Desmin (+) vessels were identified in 9/16 (56.3%) AVMs. D2-40 was uniformly negative in all specimens. AVMs were negative for GLUT-1 (11/14, 78.6%) except for 2 cases (2/14, 14.3%) exhibiting focal limited cytoplasmic GLUT-1 immunoreactivity. One case was equivocal for GLUT-1. Masson trichrome highlighted smooth muscle cells, while elastic fibers were identified in thick-wall arteries.ConclusionsAVMs of the jaws generally lack expression of GLUT-1, similar to soft tissue vascular malformations. Clinico-radiographic features of intraosseous AVMs in the current study were consistent with previous reports, although mean age was higher.



http://ift.tt/2otOxOw