The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice

Publication date: Available online 23 April 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Jing Feng, Jialie Luo, Madison R. Mack, Pu Yang, Feng Zhang, Guan Wang, Xuan Gong, Tao Cai, Zhinan Mei, Brian S. Kim, Shijin Yin, Hongzhen Hu

Teaser

The psoriasis biomarker hBD2 produces a robust scratching response in a TLR4-dependent manner in mice. TRPV1 is a downstream mediator of hBD2-induced itch. These findings suggest that hBD2 might act as an endogenous pruritogen in psoriatic itch.


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