Effect of in-situ application of Simvastatin gel in Surgical Management of Osseous defects in Chronic Periodontitis-A Randomized Clinical Trial

Publication date: Available online 23 May 2017
Source:Journal of Oral Biology and Craniofacial Research
Author(s): Rajeev Ranjan, Sudhir R. Patil, Veena H.R.
BackgroundThe present randomized control study was designed to investigate the effect of in situ application of 1.2mg Simvastatin (SV) gel in surgical management of Intrabony defect in chronic periodontitis patients.Methodology20 patients contributing 40 sites were categorized into two treatment groups: Open flap debridement plus 1.2mg SV gel (Group 1) and Open flap debridement plus Placebo gel (Group 2). Gingival index (GI), Plaque index (PI), Pocket depth (PD) and clinical attachment level (CAL) were recorded at baseline, 3 months, 6 months and 9 months. At baseline and at the end of 6 and 9 months Radiographic evaluation of Intrabony defect fill was done using Image j software.ResultsSignificant reduction of GI, PD and gain in CAL was observed at the end of 9 months in both group. Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months.ConclusionHigher amount of decrease in GI and PD along with more amount of CAL gain was observed in treatment group than controlled group. Radiological assessment confirmed that significant intrabony defect fill and percentage fill of original defect in treatment group than controlled group.



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