Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Σάββατο 20 Μαΐου 2017

Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma

Publication date: Available online 19 May 2017
Source:Annals of Allergy, Asthma & Immunology
Author(s): Suzanne L. Pollard, John J. Lima, Edward Mougey, Karina Romero, Carla Tarazona-Meza, Katherine Tomaino, Gary Malpartida Guzmán, Nadia N. Hansel, William Checkley
BackgroundEvidence suggests free mono-hydroxyvitamin D (25[OH]D) concentrations are more strongly linked to certain outcomes than total concentrations; however, no studies have examined the relation between free 25(OH)D and respiratory or allergic disease.ObjectiveTo examine associations between total and free 25(OH)D concentrations and asthma outcomes.MethodsWe quantified total and free 25(OH)D concentrations in 137 Peruvian children with asthma and 152 children without asthma and examined associations with asthma outcomes.ResultsMean age ± SD was 13 ± 2.5 years, and 50.2% were boys. Mean total and measured free 25(OH)D concentrations were 29 ± 9.5 ng/mL and 5.0 ± 1.3 pg/mL, respectively. Lower free but not total 25(OH)D concentrations were significantly associated with atopy in all children (total, odds ratio [OR] 1.3 per 10-ng/mL decrease, 95% confidence interval [CI] 0.95–1.7, P = .12; vs free, OR 1.3 per 1-pg/mL decrease, 95% CI 1.0–1.6, P = .02) and children with asthma (total, OR 1.1 per 10-ng/mL decrease, 95% CI 0.75–1.7, P = .57; vs free, OR 1.6 per 1-pg/mL decrease, 95% CI 1.0–2.5, P = .04). Free but not total 25(OH)D levels were significantly associated with pre-bronchodilator forced expiratory volume in 1 second (total, 0.11 L, −0.12 to 0.34, P = .34; vs free, 0.20 L, 0.021–0.39, P = .03) and forced vital capacity (total, 0.13 L, −0.12 to 0.37, P = .31; vs free, 0.22 L, 0.026–0.42, P = .03) Z-scores in children with asthma.ConclusionAtopy, forced expiratory volume in 1 second, and forced vital capacity were more strongly linked to free than to total 25(OH)D concentrations, suggesting the free form might be more relevant in modulating allergic disease risk and pulmonary function in children with asthma.



http://ift.tt/2rBVdXJ

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου