Human Group 2 innate lymphoid cells do not express the IL-5 receptor

Publication date: Available online 10 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Adam K.A. Wright, Cathryn Weston, Batika M.J. Rana, Christopher E. Brightling, David J. Cousins

Teaser

Capsule summary: Group 2 innate lymphoid cells (ILC2s) are upstream regulators of IL-5-dependent eosinophil function in asthma. We've shown that ILC2s do not express the IL-5R and thus IL-5R-dependent therapeutic interventions (e.g. Benralizumab) are unlikely to be mediated directly on ILC2s.


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