Neutrophil to Lymphocyte Ratio Decreases After Treatment of Psoriasis with Therapeutic Antibodies

Abstract

Although neutrophils are a histologic hallmark of psoriasis, it is unclear whether neutrophils are simply effector cells or drive pathogenesis. A recent psoriasis study with murine models evaluated various chemokines, lipids, and cytokines proposing that neutrophils are key players in positive feedback loops perpetuating the disease.¹ Additionally, when neutrophils are depleted in pustular psoriasis, the disease drastically improves.² There is mounting evidence supporting the use of neutrophil to lymphocyte ratio (NLR) as a marker of inflammation in active psoriasis. While absolute neutrophil counts (ANC) varies significantly amongst individuals, NLR may serve as an individually-normalized measure of relative neutrophil counts in psoriasis patients, and has been shown to be elevated in psoriasis patients with severe disease.^3-5

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