Rhabdomyosarcoma of the head and neck: impact of demographic and clinicopathologic factors on survival

Publication date: Available online 30 May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Robert J. Lee, Kevin K. Lee, Thomas Lin, Armin Arshi, Serena A. Lee, Russell E. Christensen
ObjectiveTo determine the survival factors for patients diagnosed with rhabdomyosarcoma of the head and neck.Study DesignPatients diagnosed with rhabdomyosarcoma of the head and neck between 1973 and 2012 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier and Cox proportional hazard regression models were performed to determine the demographics, prognostic factors, and treatment modalities that determine overall survival (OS) and disease-specific survival (DSS).Results503 patients diagnosed with rhabdomyosarcoma of the head and neck were analyzed. 51.3% were male and 48.7% were female with a median OS of 4.9 years. Kaplan-Meier analysis determined 5-year survival rates of 30% for OS and 50% for DSS. Multivariate analysis found that age at diagnosis, tumor extent of disease, surgical resection, and radiation therapy were independent predictors of OS and DSS.ConclusionsThis study, to our knowledge, is the largest year span study to date determining the factors of survival for rhabdomyosarcoma of the head and neck. Older age at diagnosis, histological subtype of alveolar rhabdomyosarcoma, and further extent of disease were associated with decreased survival. Surgical resection improves survival in patients with localized or regional disease while radiation therapy confers survival benefit in patients with distant extent.



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