Melanoma Metastasis to the Mandible ‐ Case Report and Comprehensive Literature Review

Publication date: Available online 1 June 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Peter D. Cervenka, Leonel Perez, Daniel E. Perez, Bradley Jones
With the incidence of melanoma increasing yearly, there is a need for heightened awareness of its metastatic potential and for screening with appropriate referral for identification of pre-metastatic lesions. Melanoma has a 16-25 month time to metastasize from a localized disease to one with a median survival of only 12 months or less once metastasis occurs. Nearly one-third of oral metastases are found to be the first indication of occult malignancy from a distant site. We present the case of a 54 year-old female with a longstanding undiagnosed acral lentiginous melanoma (ALM) with metastasis to the maxillofacial region. She underwent resection and died 7 months later. We analyzed case reports and current literature for biological mechanisms of metastasis, risk factors, clinical presentation, classifications, staging, treatment modalities, prognosis and current therapy modalities.



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