Obstructive sleep apnoea in craniofacial microsomia: analysis of 755 patients

Publication date: Available online 19 June 2017
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): C.J.J.M. Caron, B.I. Pluijmers, B.D.P.J. Maas, Y.P. Klazen, E.S. Katz, F. Abel, M.P. van der Schroeff, I.M.J. Mathijssen, D.J. Dunaway, C. Mills, D.S. Gill, N. Bulstrode, B.L. Padwa, E.B. Wolvius, K.F.M. Joosten, M.J. Koudstaal
A retrospective cohort study was set up to analyse the prevalence and treatment of obstructive sleep apnoea (OSA) in relation to the severity of the deformity in patients with craniofacial microsomia (CFM). This study included a population of 755 patients with CFM from three craniofacial centres. Medical charts were reviewed for severity of the deformity, types of breathing difficulty, age at which breathing difficulty first presented, treatment for OSA, and treatment outcome. In total, 133 patients (17.6%) were diagnosed with OSA. Patients with Pruzansky IIB/III classification or bilateral craniofacial microsomia were significantly more often diagnosed with OSA than unilaterally affected patients of Pruzansky I/IIA classification. The initial treatment of OSA consisted of adenotonsillectomy, tracheotomy, or non-invasive positive pressure ventilation. Thirty-seven patients received more than one treatment (range 1–3). In this study, the prevalence of OSA in patients with CFM was higher than the prevalence in the healthy population described in the literature. Although several treatment modalities are available for the treatment of OSA in patients with CFM, treatment should be individualized and based on clinical symptoms, the severity of the deformity, and comorbidities.



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