Advances in Asthma 2016: Designing Individualized Approaches to Management

Publication date: Available online 12 July 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): William C. Anderson, Andrea Apter, Cullen M. Dutmer, Daniel A. Searing, Stanley J. Szefler
In this years Advances in Asthma review we discuss viral infections in asthma and potential therapeutic agents, the microbiome, novel genetic associations with asthma, air quality and climate effects on asthma, exposures during development and long term sequelae of childhood asthma, patient centered outcome research, and precision medicine. In addition, we discuss application of biomarkers to precision medicine, and new information on asthma medications. New evidence indicates that rhinovirus-triggered asthma exacerbations become more severe as the degree of sensitization to dust mite and mouse increase. The two biggest drivers of asthma severity were an allergy pathway starting with allergic sensitization and an environmental tobacco smoke pathway. In addition, allergic sensitization and blood eosinophils can be used to select medications for management of early asthma in young children. These current findings, among others covered in this review, represent significant steps towards addressing rapidly advancing areas of knowledge that have implications for asthma management.



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