Influence of surgical decompression on the expression of inflammatory and tissue repair biomarkers in periapical cysts

Publication date: Available online 5 July 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Janderson Teixeira Rodrigues, Henrique dos Santos Antunes, Luciana Armada, Fábio Ramôa Pires
The biological effects of surgical decompression on the epithelium and connective tissues of periapical cysts are not fully comprehended.Objectiveto evaluate the expression of tissue repair and inflammatory biomarkers in periapical cysts before and after surgical decompression.Study designnine specimens of periapical cysts treated with decompression before undergoing complete surgical enucleation were immunohistochemically analyzed to investigate the expression of IL-1β, TNFα, TGFβ1, MMP9, Ki-67 and EGFR. Expression of the biomarkers was classified as positive, focal, or negative. Ki-67 immunoexpression was calculated as a cell proliferation index. THE EXPRESSION OF THE BIOMARKERS WAS COMPARED IN THE SPECIMENS FROM THE DECOMPRESSION AND FROM THE FINAL SURGICAL PROCEDURE.Resultsthe computed tomography demonstrated that the volume of all cysts reduced after decompression. There were no differences in the immunoexpression of the pro-inflammatory and tissue repair biomarkers when comparing the specimens obtained before and after the decompression.Conclusionsthe surgical decompression was efficient in reducing the volume of periapical cysts before the complete surgical enucleation. When comparing the specimens obtained from the surgical decompression and from the complete surgical removal, the immunohistochemical analysis did not show a decrease in pro-inflammatory biomarkers neither did it show an increase in tissue repair biomarkers.



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