Abstract
Background
Oral potentially malignant disorders harbour unpredictable risk for squamous cell carcinoma development. Current management requires tissue biopsy for histopathology characterisation, dysplasia grading and targeted intervention to 'high risk' lesions, although evidence-based guidelines are limited and diagnoses subjective. This study investigated the use of adjunctive oral brush biopsy techniques during the management of potentially malignant disorders in a UK hospital population.
Methods
Retrospective review of a 310 PMD patient cohort presenting to Maxillofacial Surgery in Newcastle upon Tyne with new, single-site lesions between December 2009 and May 2014. Patients underwent Orcellex® brush biopsy and liquid-based cytology examination in addition to conventional biopsy techniques, with management proceeding along established care pathways. Patient demographics, cytology data, most significant histopathology diagnoses and clinical outcome were all documented at the study census date (31.12.15).
Results
170 male & 140 female patients (age range 18-91yrs), exhibiting primarily leukoplakia (86.5%) at floor of mouth and ventro-lateral tongue sites (44.9%), were identified. Management comprised: observation (49.7%), laser surgery (44.9%), anti-fungal treatment (3.5%), and Head & Neck clinic referral following cancer diagnosis (1.9%). Clinical outcomes were: disease free (51.3%), persistent PMD (42.3%) and malignant transformation (6.4%). Histology and cytology diagnoses strongly correlated (r=0.305). Treatment modality, lesion site, histology and cytology diagnoses were the best predictors of clinical outcome.
Conclusions
Orcellex® brush cytology provides reliable diagnoses consistent with conventional histopathology and offers less invasive, adjunctive assessment appropriate for long-term monitoring of patients in specialist clinics.
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