Incidence, Prevalence, and Mortality of Adamantiades-Behçet's disease in Korea: A Nationwide, Population-based Study (2006–2015)

Abstract

Background

The epidemiology of Adamantiades-Behçet's disease varies among ethnic populations worldwide. Trends in the incidence of Adamantiades-Behçet's disease have not been investigated based on the Korean National Health Insurance database.

Objectives

This study investigated the incidence and mortality of Adamantiades-Behçet's disease by age using nationwide population data in Korea.

Methods

A nationwide population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015. The incidence of Adamantiades-Behçet's disease was calculated by age, sex, calendar year, and habitat. And comorbid metabolic diseases were also analyzed in patients with Adamantiades-Behçet's disease.

Results

The annual incidence of Adamantiades-Behçet's disease per 100,000 person-years was 3.976 (2.587 for males and 5.373 for females) from 2006 to 2015. The incidence of Adamantiades-Behçet's disease peaked among people in their 40s (6.561 per 100,000 person-years). Incidence was significantly higher in subjects with comorbid metabolic conditions, such as diabetes mellitus, hypertension, and dyslipidemia. The mortality rate per 1,000 person-years increased with age in Adamantiades-Behçet's disease patients.

Conclusions

This study showed the incidence, prevalence, and mortality of Adamantiades-Behçet's disease. Metabolic conditions increased the risk of Adamantiades-Behçet's disease among Koreans.

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