Prevalence of Human Papillomavirus in Benign and Malignant Laryngeal Lesions in Egyptian Patients: Cross-Sectional Study

Abstract

Objective

To assess the prevalence of HPV in benign and malignant laryngeal lesions among Egyptian patients.

Design

Observational analytical cross-sectional study.

Setting

Ain Shams University hospital, Otorhinolaryngology department.

Participants

Formalin-fixed paraffin-embedded specimens of 126 patients (70 benign laryngeal lesions and 56 squamous cell carcinoma lesions) were assessed for the presence of HPV DNA using MY09/11 PCR-based DNA detection.

Main outcome measures

Percentage of positive samples was calculated.

Results

All 70 benign laryngeal lesion specimens were negative for the HPV DNA while 2 of the 56 squamous cell carcinoma lesions (3.6%) were positive.

Conclusions

The presence of HPV DNA in only two specimens in our study suggests that the proportion of laryngeal squamous cell carcinomas attributable to infection by HPV seems to be very low in Egypt.

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