Removal of a sequestrum by a patient with medication-related osteonecrosis of the jaw

Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of dentoalveolar surgery after treatment with antiresorptive or antiangiogenic agents.1 Patients are diagnosed with MRONJ if they have or have had: current or previous treatment with antiresorptive or antiangiogenic agents, exposed bone or bone that can be probed through an intraoral or extraoral fistula that has persisted for more than eight weeks, and no history of radiation to the jaws or metastatic disease to the jaws.

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