Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Κυριακή 1 Οκτωβρίου 2017

A novel PAX9 mutation causing oligodontia

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Publication date: December 2017
Source:Archives of Oral Biology, Volume 84
Author(s): Eiman Mohammed Daw, Christian Saliba, Godfrey Grech, Simon Camilleri
IntroductionAn extended family presenting with several members affected by developmentally missing teeth was investigated by analysis of the MSX1 and PAX9 genes.Materials and methodsSaliva samples were collected and DNA extracted. Primers were designed to span the exons and intron-exon junctions of the MSX1 and PAX9 genes. These primers were optimised using gradient Polymerase Chain Reaction. The amplified fragments were sent for Sanger sequencingResultsa novel heterozygote missense mutation in exon 3 of PAX9 (c.296G > C, p.A99P), was found in two severely affected members of the family as well as a potentially pathogenic heterozygote variant (c.119C > G, p.A40G) in exon 1 of the MSX1 gene.ConclusionThe PAX9 A99P mutation is in the DNA binding domain and is predicted to be pathogenic.



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