Effects of Low Level Laser Therapy with A Herbal Extract on Alveolar Bone Healing

Publication date: Available online 16 October 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Anıl Özyurt, Çiğdem Elmas, Cemile Merve Seymen, Veysel Tuncay Peker, Bülent Altunkaynak, Mehmet Nadir Güngör
PurposeThe aim of this study was to investigate the effect of a gallium–aluminum–arsenide (GaAlAs) diode laser used in low-level laser therapy with the application of Mecsina herbal hemostopper on mandibular alveolar bone healing.MethodsStandard semi-spherical bone defects were created on the left mandibular diastema sites of 32 female Long Evans rats. The experimental animals were allocated to four groups as follows: control group (nothing applied), laser group (GaAlAs diode low-level laser therapy), Mecsina group, and laser–Mecsina combination group. To the bone defects, 0.01 mL Mecsina in liquid form was applied. The laser treatment was performed for a duration of 7 days after surgery at an energy dose of 10 J/cm². All animals were sacrificed to observe hard tissue healing histologically, immunohistochemically, and radiologically at 30 days after the surgery.ResultsHistological assessment showed that there were significantly more calcified tissue areas and significantly more osteoblast cells in the laser and laser–Mecsina combination groups than in the other groups (p < 0.01). Qualitative morphological assessment showed that more bone tissue was present in the laser–Mecsina combination group than in other groups.ConclusionThis study demonstrated that low-level laser therapy, Mecsina application, and combined treatments were effective on alveolar bone healing among all the tested treatment modalities.



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