Novel middle ear applications for a synthetic cerebrospinal fluid (CSF) sealant

Abstract

TissuePatchDural^™ is an easy to store and apply synthetic CSF sealant.

Its breakdown products are naturally occurring and non-toxic.

Its use appears safe in the middle ear.

It is shown to successfully close mastoid CSF leaks.

Its use as an adjunct in sealing middle ear fistulae is also demonstrated.

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