Prospective and randomized evaluation of ChronOS® and BioOss® in human maxillary sinuses: Histomorphometric and immunohistochemical assignment for Runx 2, VEGF, and Osteocalcin

Publication date: Available online 10 October 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): João Paulo Bonardi, Rodrigo dos Santos Pereira, Fernanda Brasil Jorge Daura Boos, Leonarod Perez Faverani, Geraldo Luiz Griza, Roberta Okamoto, Eduardo Hochuli-Vieira
PurposeThe aim of this study was to compare ChronOS™ (beta-tricalcium phosphate), BioOss^®, and their addition to autogenous bone graft in a 1:1 ratio in human maxillary sinuses bone augmentation.Materials and MethodsThirty maxillary sinuses were divided in five groups: group 1, which included six maxillary sinuses grafted with autogenous bone graft alone; group 2 with six maxillary sinuses with ChronOS™; group 3 with six maxillary sinuses grafted with ChronOS™ and autogenous bone graft in a 1:1 ratio; group 4 with six maxillary sinuses grafted with BioOss^®; and group 5 which included six maxillary sinuses with BioOss^® and autogenous bone graft in a 1:1 ratio. The number of samples for each group were determined by the statistical power test.ResultsThe area medians for the new bone formed for groups 1, 2, 3, 4, and 5 were 121917.0 μm², 83787.0 μm², 99295.0 μm², 65717.0 μm², and 56230.0 μm², respectively. Statistical significant differences occurred between groups 3 and 5, 1 and 4, and 1 and 5 (p < 0.05). The median area of the remaining biomaterial for each group was 2900.5 μm², 5291.0 μm², 2662.0 μm², 56258.5 μm², and 64753.5 μm² for group 1, 2, 3, 4 and 5, respectively. Statistical significant differences occurred between groups 1 and 5, 3 and 5, and 2 and 5 (p < 0.05). The connective tissue presented in group 1 was 67829.0 ± 22984.6 μm²; it was 97445.9 ± 18983.3 μm² for group 2, 88256.0 ± 21820.5 μm² for group 3, and 65501.8 ± 6297.6 and 70203.2 ± 13421.3 μm² for groups 4 and 5, respectively.ConclusionChronOS™ and its mixture with autogenous bone graft presented with behavior similar to that of autogenous bone graft alone. However, the groups with BioOss^® demonstrated results for immunolabeling assessment indicating maturation of the grafted bone.



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