Differential expression of STAT-3 in subtypes of oral lichen planus: a preliminary study

Publication date: Available online 14 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Guanhuan Du, Junjun Chen, Yanni Wang, Tianyi Cao, Leilei Zhou, Yufeng Wang, Xiaozhe Han, Guoyao Tang
Objective.This study aimed to examine the expression of signaling transduction proteins and their possible correlation with different clinical subtypes of oral lichen planus (OLP).Study design.We examined the immunoexpression and phosphorylation status of 21 signaling transduction proteins of OLP (n=10) and normal groups (n=8) using PathScan® analysis. We detected expression of STAT-3 and p38MAPK in tissues of OLP (n=40) and normal groups (n=10) by immunohistochemistry.Results.PathScan® analysis showed that STAT-3(Ser727) expression in normal control (N), reticular OLP (R-OLP) and erosive OLP (E-OLP) group was gradually elevated (R-OLP vs N, P=0.001; E-OLP vs N, P<0.001; E-OLP vs R-OLP, P=0.002). Immunohistochemistry showed that STAT-3 expression in the epithelium of normal control, reticular OLP and erosive OLP was consistent with PathScan® analysis (R-OLP vs N, P<0.001; E-OLP vs N, P<0.001; E-OLP vs R-OLP, P=0.036). Both PathScan® (P=0.012) and immunohistochemistry (P<0.001) showed that, p38MAPK expression was significantly higher than normal controls. However, a significant difference was not seen between reticular OLP and erosive OLP groups.Conclusions.Our results provide information indicating that STAT-3 may be involved in OLP development and progression and account for different clinical manifestations.



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