Intralesional Bleomycin Injection for Propranolol-Resistant Hemangiomas

Propranolol has been the first-line treatment for alarming hemangiomas. However, some hemangiomas are propranolol-resistant. The authors reported 1 propranolol-resistant hemangioma which was treated with intralesional bleomycin injections. Sixteen months after 3 injections, the lesion still remained stable. Its potential mechanism was clarified by ultrasonic monitoring. Intralesional bleomycin injection can be considered an ideal option in treating propranolol-resistant hemangiomas. Address correspondence and reprint requests to Xiaoxi Lin, MD, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Zhizaoju Road, Shanghai 200011, China; E-mail: linxiaoxi@126.com Received 7 November, 2016 Accepted 27 August, 2017 The first 2 authors contributed equally to this work and should be viewed as co-first authors. This study was supported by grants of the National Natural Science Foundation of China (81272127, 81601699) and the Joint Research Project on Important Disease of Shanghai Health System (2013ZYJB0014). The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

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