The atopic march: Fact or folklore?

Atopic dermatitis, allergic rhinitis, and asthma are common, frequently appear together, and usually begin in early life, thus posing lifelong burdens for many affected patients. Based on clinical observations and studies of disease prevalence, it has been proposed that the sequential development of atopic dermatitis, asthma, and allergic rhinitis is a causal relationship now known as the "atopic march"1 (Fig 1). The concept of an atopic march has captured our interest because it earmarked an allergic harbinger of "bad things" to follow.

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