Skull Base Metastasis From Occult Renal Cell Carcinoma

Skull base metastases are extremely rare. The authors report a case of a 65-year-old man who presented with a headache and diplopia secondary to a skull base metastasis from occult renal cell carcinoma. Since there were no other systemic metastases, radical nephrectomy and radiotherapy of the unresectable skull base location were performed. He subsequently received immunotherapy with sunitinib, everolimus, and sorafenib with local and systemic control of the disease after 53 months from surgery. When metastasis is unresectable radical nephrectomy and radiotherapy aimed at the metastasis may be of benefit improving quality of life. Immunotherapy may provide alternative treatment strategies improving the outcomes of patients affected by this rare pathology with historically poor prognosis. Address correspondence and reprint requests to Maria Silvia Rosa, MD, Division of ENT Department—Head and Neck Surgery, University of Piemonte Orientale "A. Avogadro," Corso Mazzini 18, 28100 Novara, Italy; E-mail: m.silviarosa@gmail.com Received 18 September, 2017 Accepted 14 January, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

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