EVOLUTION OF GLYCAEMIC CONTROL AND VARIABILITY AFTER KIDNEY TRANSPLANT

AbstractBackgroundThe evolution of glycaemic changes after kidney transplantation has not been described. We prospectively examined glycaemic control and variability over time from transplantation using continuous glucose monitoring(CGM).MethodCGM devices were fitted for 3-5 days at time of transplant, month 3 and month 6 posttransplant. Indices of glucose control (mean glucose, percent time in hyperglycemic range and GRADE score) and variability were calculated. An OGTT was performed at month 3.ResultsTwenty-eight patients (mean age 45±15yrs) were enrolled, 64% male, 75% Caucasian, receiving tacrolimus, mycophenolate and prednisolone (93%). Of 24 patients with complete CGM data at month 0, 3 had prior diabetes and 6(25%) developed new onset diabetes (NODAT). Hyperglycaemia(>11.1mM) was evident in 79% during days 0-3 posttransplant, particularly between 1-9pm. Compared to recipients without diabetes, recipients with prior diabetes had higher mean glucose [7.8mM (95%CI 7.4-8.2) vs 9.9mM (95%CI 8.9-10.8), p11.1mM) was evident in 79% during days 0-3 posttransplant, particularly between 1-9pm. Compared to recipients without diabetes, recipients with prior diabetes had higher mean glucose [7.8mM (95%CI 7.4-8.2) vs 9.9mM (95%CI 8.9-10.8), p

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