Isolated light chain amyloidosis involving the parotid gland: A case report

Publication date: Available online 8 March 2018
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Barzi Gareb, Michael Perry, Paul Joseph Tadrous
Amyloidosis in the parotid gland is rare and is usually associated with systemic amyloidosis. Localized amyloidosis in the parotid gland is extremely rare. The authors present a case of localized light chain amyloidosis of the parotid gland without systemic involvement. A 70-year-old woman with an asymptomatic presented with a swelling of the right parotid region. Physical examination, hematological and biochemical investigations, imaging, and cytology were non-conclusive. The patient underwent an extracapsular dissection of the right parotid gland. Histology showed that the tissue of the right parotid gland mostly consisted of amyloid depositions. The amyloid stained with antibodies to lambda light chains. Additional investigations showed no systemic involvement. The patient is asymptomatic 5 months after surgery. Clinicians should be aware of the possibility of localized AL amyloidosis in the parotid gland, especially if MRI, CT-imaging, and ultrasound are non-conclusive, and should recognize, evaluate, and treat it accordingly.



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