Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array (CBA) in saliva of patients with oral lichen planus

Publication date: Available online 6 March 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Wei Wei, Qianqian Sun, Yiwen Deng, Yufeng Wang, Guanhuan Du, Chencheng Song, Chenxi Li, Mengxue Zhu, Guoyao Tang
ObjectiveTo measure Th1/Th2 related cytokines expression in saliva from patients with oral lichen planus (OLP), compared to health controls (HC) and disease controls with recurrent aphthous ulcers (RAU).Study DesignSaliva from 41 patients with OLP, 14 HC and 14 RAU was collected for Th1/Th2-related cytokines analysis using cytometric bead array (CBA). Disease activity in OLP was recorded by Reticulation/keratosis, erythema and ulceration (REU) scores.ResultsIL-6, IL-10, IFN-γ and IFN-γ/ IL-4 in saliva were significantly higher in OLP than health control (HC) group. A positive and significant correlation between IL-6, IL-10 and REU scores in OLP groups was revealed. Significantly increased IL-4, IL-5, IL-6, IL-10, TNF-α and IFN-γ/ IL-4 were found in RAU group.ConclusionSalivary cytokine profiles analyzed by CBA may provide a convenient research approach to OLP. Data indicated a complicated Th1/Th2 related cytokine profiles changes rather than simple dominance model in OLP. IL-10 and especially IL-6 might provide a surrogate endpoint for monitoring OLP.



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