IL-33 induces functional CCR7 expression in human mast cells

Publication date: Available online 19 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Maiko Emi-Sugie, Sumika Toyama, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto

Teaser

Functional CCR7 expression—which enables Erk 1/2 phosphorylation, chemotaxis and enhancement of cytokine production upon exposure to CCR7 ligands—was induced in human mast cells, strongly by IL-33 and weakly by anti-IgE Ab stimulation.


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