On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3

Publication date: Available online 19 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Janina Dose, Anke Schloesser, Guillermo G. Torres, Geetha Venkatesh, Robert Häsler, Friederike Flachsbart, Wolfgang Lieb, Almut Nebel, Gerald Rimbach, Patricia Huebbe

Teaser

Under conditions reflecting the Western lifestyle, APOE ε4 vs. APOE ε3 may be associated with a lower expression of markers important in innate immune activation. The results encourage further investigations into the role of the APOE genotype in metabolic diseases associated with chronic inflammation.


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