Pharmacodynamics of regulatory T cells in mice and humans treated with low-dose interleukin-2

Publication date: Available online 18 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Guillaume Churlaud, Chadi Abbara, Pierre-Axel Vinot, Gwladys Fourcade, Paul-Gydeon Ritvo, Roberta Lorenzon, Michelle Rosenzwajg, Bertrand Diquet, David Klatzmann

Teaser

We have developed and validated a mathematical model depicting and predicting the effect of low-dose interleukin-2 on Treg expansion in mice and humans. This model should help in the design of optimal therapeutic schemes for the long-term treatment of various chronic autoimmune, inflammatory or allergic diseases.


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